cAMP

Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. It should not be confused with 5'-AMP-activated protein kinase (AMP-activated protein kinase).

Cat. No.	Product Name	CAS No.	Purity
TMA2419	Catalponol 梓酚	34168-56-4	98%
TMA2419	Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the inc...
TN4433	Licoarylcoumarin 化合物 TN4433	125709-31-1	98%
TN4433	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE st...
TN4277	Isocupressic acid 化合物 TN4277	1909-91-7	98%
TN4277	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reprodu...
TMA1944	Protopine hydrochloride 化合物 TMA1944	6164-47-2	98%
TMA1944	Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracell...
TN4317	Isopedicin 化合物 TN4317	4431-42-9	98%
TN4317	Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA thr...
TN3607	Catalpalactone 化合物 TN3607	1585-68-8	98%
TN3607	Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264....
TN4551	Methyl orsellinate 化合物 TN4551	3187-58-4	98%
TN4551	Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
TN1841	Kushenol A 苦参新醇 A	99217-63-7	98%
TN1841	Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushe...
TN2918	3-Acetoxy-8(17),13E-labdadien-15-oic acid 化合物 TN2918	63399-37-1	98%
TN2918	ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane invo...
TN4489	Manassantin A 化合物 TN4489	88497-87-4	98%
TN4489	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN4178	Gyrophoric acid 石耳酸	548-89-0	98%
TN4178	Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations, they can effectively prevent cytotoxic, apoptotic and cytoskeleton...
TN3882	Dodoviscin A 化合物 TN3882	1372527-25-7	98%
TN3882	Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobu...
TN2039	Panaxydol 人参环氧炔醇	72800-72-7	98%
TN2039	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MA...
TN1504	Citreorosein 化合物Citreorosein	481-73-2	98%
TN1504	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
TN4051	Fargesone B 化合物 TN4051	116424-70-5	98%
TN4051	Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.
TMA0003	Trans-caffeic acid 化合物 TMA0003	501-16-6	98%
TMA0003	Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and...
T80666	2-PCCA hydrochloride 2-PCCA盐酸盐	1609563-70-3	99.96%
T80666	2-PCCA hydrochloride 是一种外消旋体，是一种具有有效性和选择性的 GPR88 受体激动剂，在 HEK293 细胞中显示出对 GPR88 介导的 cAMP 的产生有抑制作用，EC50 值为 116 nM。
TN1266	3-O-Methylquercetin 3-邻甲基槲皮素	1486-70-0	99.8%
TN1266	3-O-Methylquercetin 是分离自植物Rhamnus nakaharai 的天然产物，可抑制总 cAMP 和cGMP-phosphodiesterase (PDE)。它对PDE1、PDE5、PDE 和PDE4的IC50分别是31.9 μM、86.9 μM、18.6 μM 和1.6 μM。
TN1121	Evocarpine 吴茱萸卡品碱	15266-38-3	99.77%
TN1121	Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱，有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。
T15485	HJC0197 化合物HJC0197	1383539-73-8	99.76%
T15485	HJC0197 是Epac1(cAMP 1 直接激活的交换蛋白) 和Epac2 拮抗剂，其对Epac2 的IC50值为5.9 μM。它在等浓度 cAMP 存在下能够降低 Epac1 介导的 Rap1-GDP 交换活性。它能够选择性阻断 cAMP 诱导的 Epac 活化。