首页工具

FOXO1

Forkhead box protein O1 (FOXO1) also known as forkhead in rhabdomyosarcoma (FKHR) is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. It is primarily regulated through phosphorylation on multiple residues; its transcriptional activity is dependent on its phosphorylation state.

Cat. No.	Product Name	CAS No.	Purity
TN4390	Kihadanin B 化合物 TN4390	73793-68-7	98%
TN4390	Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
T6762	AS1842856 化合物AS1842856	836620-48-5	99.56%
T6762	AS1842856 是一种特异性的Foxo1抑制剂，IC50为 30 nM。它抑制自噬，直接与 FoxO1 结合而降低 FoxO1 的活性。
T73578	JY-2 化合物JY-2	339103-05-8	98%
T73578	JY-2 是一种具有口服活性和选择性的叉头转录因子 O1 (FoxO1) 抑制剂，具有抗糖尿病活性，对 FoxO1 转录有抑制作用。JY-2 可用于研究银屑病和糖尿病。