Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T60675 | AMPK activator 2
AMPK激活剂2
|
2410961-69-0 | 98% |
|
AMPK activator 2 是一种含氟氯胍衍生物,具有潜在的抗癌活性,可上调 AMPK 信号通路并下调 mTOR/4EBP1/p70S6K,对人类癌细胞系 (UMUC3、T24、A549) 的增殖和迁移有抑制作用。 | ||||
T20232 | Kazinol B
小构树醇B
|
99624-27-8 | 98% |
|
Kazinol B 是一氧化氮(NO)产生的抑制剂,是一种具有二甲基吡喃环的异戊烯化黄烷。Kazinol B 通过激活胰岛素-Akt 信号途径和AMPK,增强葡萄糖摄取,从而改善胰岛素敏感性。Kazinol B 刺激脂肪素的基因表达和分泌,可用于研究糖尿病。 | ||||
TN3042 | 4-Hydroxycinnamamide
化合物 TN3042
|
194940-15-3 | 98% |
|
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. | ||||
T79232 | MARK4 inhibitor 2
化合物 MARK4 inhibitor 2
|
98% |
|
|
MARK4 inhibitor 2作为MARK4的高效抑制剂,展现出对微管亲和调节激酶 4 (MARK4) 的Km值为6.3×10^7,及IC50为0.82 μM的特异性。它能够抑制癌细胞生长,适用于癌症的科学研究。 | ||||
T82165 | HTH-02-006
化合物 HTH-02-006
|
98% |
|
|
HTH-02-006,一种NUAK2抑制剂(IC50 = 126 nM),能够降低HuCCT-1细胞中磷酸化MYPT1水平,并抑制YAP驱动的细胞增殖、肝肿大和肿瘤发生,同时具备抗纤维化保护效果。 | ||||
T83125 | AMPK-α1β1γ1 activator 1
化合物 AMPK-α1β1γ1 activator 1
|
1943510-86-8 | 98% |
|
AMPK-α1β1γ1激活剂1 (M1) 是一个衍生于Indole-3-carcinoma的酰基葡萄糖醛酸代谢AMPK激活剂,专一性地针对人类β1亚型,表现出38.1nM的EC50值。该化合物能够直接结合至人AMPK α1β1γ1亚型,适用于糖尿病肾病的相关研究。 | ||||
T83127 | AMPK activator 13
化合物 AMPK activator 13
|
98% |
|
|
AMPK activator13作为AMPK激活剂,通过激活AMPK通路有效抑制3T3-L1细胞的有丝分裂克隆扩增,并增加细胞线粒体耗氧量,适用于肥胖研究。 | ||||
TN5013 | Shizukaol D
化合物 TN5013
|
142279-42-3 | 98% |
|
Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be... | ||||
T10105 | 3α-Hydroxymogrol
3α-羟基罗汉果醇
|
1343402-73-2 | 98% |
|
3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle. It is a potent AMPK activator and enhances AMPK phosphorylation. | ||||
T11570 | HL271
化合物 T11570
|
1422365-52-3 | 98% |
|
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment. | ||||
T22460 | XMD-17-51
化合物XMD-17-51
|
1628614-50-5 | 98% |
|
XMD-17-51 是一种有效且高度选择性的 NUAK1 抑制剂。 | ||||
TN4382 | Kazinol A
化合物 TN4382
|
99624-28-9 | 98% |
|
Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M ag... | ||||
T10312 | Ampkinone
化合物 T10312
|
1233082-79-5 | 98% |
|
Ampkinone is an indirect AMPK activator. | ||||
TL0014 | Pinusolide
化合物 TL0014
|
31685-80-0 | 98% |
|
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a... | ||||
TN1868 | Ligupurpuroside A
紫茎女贞苷 A
|
147396-01-8 | 98% |
|
Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L. | ||||
T1456 | Doxorubicin
阿霉素
|
23214-92-8 | 98% |
|
Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素,具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II,IC50分别为0.8 μM 和2.67 μM,从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬 。 | ||||
T16113 | ML753286
化合物 T16113
|
1699720-89-2 | 98% |
|
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (... | ||||
TN1870 | Ligupurpuroside C
紫茎女贞苷 C
|
1194056-33-1 | 98% |
|
Ligupurpuroside C can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L. | ||||
T16166 | N-[(4-Aminophenyl)methyl]adenosine
N-[(4-氨基苯基)甲基]腺苷
|
95523-13-0 | 98% |
|
N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase). | ||||
TN1670 | Ganodermanondiol
灵芝酮二醇
|
107900-76-5 | 98% |
|
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated anti... |