keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ceruletide (Caerulein) 是一种十肽,是一种安全有效的胆囊收缩剂,是一种胆囊收缩素受体激动剂,对胆囊肌肉和胆管有直接的痉挛性作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,520 | 现货 | ||
5 mg | ¥ 3,810 | 待询 | ||
10 mg | ¥ 5,470 | 待询 | ||
25 mg | ¥ 8,430 | 待询 | ||
50 mg | ¥ 11,300 | 待询 | ||
100 mg | ¥ 15,300 | 待询 |
Ceruletide 的其他形式现货产品:
产品描述 | Ceruletide (Caerulein) is a potent agonist of cholecystokinin receptor and it also is a safe and effective cholecystokinetic agent. It has a direct spasmogenic effect on the gallbladder muscle and bile ducts. |
体外活性 | Ceruletide is the same as biologically and chemically to the human gastrointestinal hormones cholecystokinin-pancreozymin (CCK) and gastrin II. Ceruletide stimulates gallbladder contraction while delaying gastric emptying and inhibiting motility in the proximal duodenum [1]. Ceruletide in supramaximal but not in physiological doses activate NF-kappaB/Rel in vitro. This activation may induce a self-defending genetic program before the onset of cellular injury and may prevent higher degrees of damage of pancreatic acinar cells after secretagogue hyperstimulation [2]. |
体内活性 | Ceruletide (5-15 ng/kg, i.v.) shows a marked spasmogenic effect on the pylorus of rats. Ceruletide also reduces blood pressure in anesthetized dogs [1]. Ceruletide (0.4-0.5 mcg/kg, i.v.; 3-4 mcg/kg, s.c.) results in emesis and evacuation of the bowel in the intact conscious dog, and recovery is complete 15-30 min after i. v. administration and 2-4 hr after s.c. administration. Ceruletide SBA stimulation may perform as well as PP SBA stimulation in dogs with the portosystemic shunt and be more sensitive for the detection of hepatic dysfunction in dogs with the upper respiratory disease [3]. |
别名 | Cerulein, Caerulein, 雨蛙素, FI-6934 |
分子量 | 1352.4 |
分子式 | C58H73N13O21S2 |
CAS No. | 17650-98-5 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 96 mg/mL (70.98 mM)
H2O: 100 mg/mL (73.94 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 0.7394 mL | 3.6971 mL | 7.3943 mL | 18.4857 mL |
5 mM | 0.1479 mL | 0.7394 mL | 1.4789 mL | 3.6971 mL | |
10 mM | 0.0739 mL | 0.3697 mL | 0.7394 mL | 1.8486 mL | |
20 mM | 0.037 mL | 0.1849 mL | 0.3697 mL | 0.9243 mL | |
50 mM | 0.0148 mL | 0.0739 mL | 0.1479 mL | 0.3697 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ceruletide 17650-98-5 GPCR/G Protein cholecystokinin Cerulein Caerulein inhibit 雨蛙素 Cholecystokinin Receptor Inhibitor FI 6934 CCK Receptor FI-6934 FI6934 inhibitor