BACE

Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons.BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs.

Cat. No.	Product Name	CAS No.	Purity
TN2217	Sophoflavescenol 槐苦参醇	216450-65-6	99.65%
TN2217	Sophoflavescenol 是异戊烯基黄酮类化合物，能够抑制PDE5的活性，IC50=0.013 μM。它也抑制 RLAR，HRAR，BACE1，AChE 和 BChE，IC50值分别为 0.30 µM，0.17 µM，10.98 µM，8.37 µM 和 8.21 µM。
TN3410	Anatabine 化合物 TN3410	581-49-7	98%
TN3410	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4865	Putraflavone 化合物 TN4865	23624-21-7	98%
TN4865	Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN2131	Questin 化合物Questin	3774-64-9	98%
TN2131	Questin 是一种从花样黄曲霉中提取出来的抗菌剂，具有抗菌活型，对V. harveyi，V. anguillarum，V. cholerae 和 V. parahemolyticus 具有抑制作用，MIC 值分别为 31.25 µg/mL，62.5 µg/mL，62.5 µg/mL 和 125 µg/mL。Quest...
TN1332	7-O-Methylaloeresin A 7-O-甲基片木素A	329361-25-3	98%
TN1332	7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
T10292	AM-6494 化合物 T10292	1874232-80-0	98%
T10292	AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
T10450	BACE1-IN-1 化合物 T10450	1310347-50-2	98%
T10450	BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
TN1434	Bavachromene 补骨脂色烯查耳酮	41743-38-8	98%
TN1434	Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
T8306	Epiberberine chloride 表小檗碱氯化物	889665-86-5	98%
T8306	Epiberberine chloride (Epiberberine (chloride)) 是一种从黄连中得到的生物碱，是一种AChE 和BChE 抑制剂，和非竞争性的BACE1抑制剂。它具有抗氧化作用，能够清除 ONOO-，可用于研究阿尔滋海默症和糖尿病。
T10452	BACE1-IN-4 化合物 T10452	2361157-92-6	98%
T10452	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T12429	PF-06751979 化合物 T12429	1818339-66-0	98%
T12429	PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
TQ0238	Lanabecestat 化合物Lanabecestat	1383982-64-6	98%
TQ0238	Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
T14338	Atabecestat 化合物 T14338	1200493-78-2	98%
T14338	Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
TN4399	Kushenol C 化合物 TN4399	99119-73-0	98%
TN4399	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T10453	BACE1-IN-5 化合物 T10453	2581114-83-0	98%
T10453	BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂，IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ，IC50为 0.82 nM。并且，BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。
T10451	BACE1-IN-2 化合物 T10451	1352416-78-4	98%
T10451	BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T6058	LY2886721 化合物LY2886721	1262036-50-9	99.94%
T6058	LY2886721 是选择性的，口服活性的 β 位淀粉样蛋白前体蛋白裂解酶 1 抑制剂，对重组人 BACE1的 IC50=20.3 nM。它对 BACE1的选择性高于对组织蛋白酶 D、胃蛋白酶、肾素的选择性，但缺乏对 BACE2的选择性。它可透过血脑屏障，并可用于研究阿尔茨海默氏病。
T6772	AZD3839 free base 化合物AZD3839	1227163-84-9	99.93%
T6772	AZD3839 free base 是一种具有口服活性的、选择性的、可透过大脑屏障的BACE1抑制剂 (Ki=26 nM)，对 BACE2 和组织蛋白酶 D 的选择性分别为 14 倍和 >1000 倍。在小鼠、豚鼠和非人灵长类动物中，它剂量和时间依赖性的降低血浆、脑和脑脊液 Aβ 水平，可用于研究阿尔茨海默病。
T4398	LX2343 化合物LX2343	333745-53-2	99.92%
T4398	LX2343 是一种非 ATP 竞争性 PI3K 抑制剂，IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂，IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
TN1343	8-Geranyloxypsoralen 8-香叶草氧基补骨脂素	7437-55-0	99.87%
TN1343	8-Geranyloxypsoralen 是一种呋喃香豆素，分离自葡萄柚，是 P450 3A4 的有效抑制剂(IC50:3.93 μM)。