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RANKL/RANK

RANKL/RANK

Receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein that in humans is encoded by the TNFSF11 gene. Receptor activator of nuclear factor κ B (RANK) is the receptor for RANKL. RANKL/RANK is associated with bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. Osteoprotegerin (OPG) is a decoy receptor for RANKL, and regulates the stimulation of the RANK signaling pathway by competing for RANKL. The cytoplasmic domain of RANK binds TRAFs 1, 2, 3, 5, and 6 which transmit signals to downstream targets such as NF-κB and JNK.
Cat. No. Product Name CAS No. Purity Chemical Structure
T80618 Narlumosbart
化合物 Narlumosbart
2646587-68-8 98%
Narlumosbart
Narlumosbart(JMT103)是一种IgG4κ型抗体,专一性靶向核因子-κB 配体受体激活剂(RANKL)。
T61531 NFATc1-IN-1
化合物NFATc1-IN-1
1912422-56-0 99.64%
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-os...
T5720 Boldine
波尔定
476-70-0 98%
Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱,从山苍子根中提取获得,具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成,并利用下调 OPG/RANKL/RANK 信号途径,改善骨破坏。它可用于研究类风湿性关节炎。
T5770 Alisol B
泽泻醇 B
18649-93-9 98%
Alisol B 是一种具有用于骨科疾病研究潜力的化合物,通过分化破骨细胞发挥其功能。
T9917 Denosumab
地诺单抗
615258-40-7 98%
Denosumab
Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性,可降髋部、低椎骨以及非椎骨骨折的风险。
Narlumosbart
T80618
Narlumosbart(JMT103)是一种IgG4κ型抗体,专一性靶向核因子-κB 配体受体激活剂(RANKL)。
NFATc1-IN-1
T61531
NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-os...
Boldine
T5720
Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱,从山苍子根中提取获得,具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成,并利用下调 OPG/RANKL/RANK 信号途径,改善骨破坏。它可用于研究类风湿性关节炎。
Alisol B
T5770
Alisol B 是一种具有用于骨科疾病研究潜力的化合物,通过分化破骨细胞发挥其功能。
Denosumab
T9917
Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性,可降髋部、低椎骨以及非椎骨骨折的风险。
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