Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.

Cat. No.	Product Name	CAS No.	Purity
TP1007	β-Amyloid (1-42), human 大豆肽	107761-42-2	99.52%
TP1007	β-Amyloid (1-42), human 是一种由 42 个氨基酸组成的肽，在阿尔茨海默病的发病机制中起关键作用。
TN1798	Isorosmanol 异迷迭香酚	93780-80-4	98.85%
TN1798	Isorosmanol 具有抗氧化、神经保护和神经营养作用，可能用于老年性疾病，如认知功能下降和色素沉着。
T19011	Hoechst 34580 化合物Hoechst 34580	23555-00-2	98.84%
T19011	Hoechst 34580 (HOE 34580) 是细胞渗透性荧光染料，可用于 DNA 和核染色。
T14525	Begacestat 化合物 T14525	769169-27-9	98%
T14525	Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
TN3410	Anatabine 化合物 TN3410	581-49-7	98%
TN3410	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN1653	Fustin 黄颜木素	20725-03-5	98%
TN1653	Fustin 是植物漆树 (Rhus verniciflua Stokes) 的植物性黄烷醇成分。 Fustin 对 6-羟基多巴胺诱导的神经元细胞死亡具有保护作用。
TN1919	(+)-Medioresinol 梣皮树脂醇	40957-99-1	98%
TN1919	Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
TN4865	Putraflavone 化合物 TN4865	23624-21-7	98%
TN4865	Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN3618	Cedrin 化合物 TN3618	75513-81-4	98%
TN3618	Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN4571	Mirabijalone D 化合物 TN4571	485811-84-5	98%
TN4571	Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
T19013	Hoechst 34580 tetrahydrochloride 化合物 T19013	T19013	98%
T19013	Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T10453	BACE1-IN-5 化合物 T10453	2581114-83-0	98%
T10453	BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂，IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ，IC50为 0.82 nM。并且，BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。
T19142	4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 化合物 T19142	566169-98-0	98%
T19142	4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 化合物 TN3218	100667-52-5	98%
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
TN4635	Neoechinulin A 化合物 TN4635	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
T7003	Leucomethylene blue mesylate 化合物TRx0237 mesylate	1236208-20-0	99.99%
T7003	Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM)，可用于阿尔兹海默症的研究。
T4398	LX2343 化合物LX2343	333745-53-2	99.92%
T4398	LX2343 是一种非 ATP 竞争性 PI3K 抑制剂，IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂，IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
T4S0350	Licochalcone B 甘草查尔酮 B	58749-23-8	99.9%
T4S0350	Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ，分解预先形成的 Aβ42原纤维，并通过螯合金属离子抑制金属诱导的 Aβ42聚集。
T6708	Tolcapone 托卡朋	134308-13-7	99.89%
T6708	Tolcapone (Ro 40-7592) 是一种选择性，具有口服活性的外周和中枢COMT 抑制剂，在肝脏中对 COMT 的IC50为 773 nM。它还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂，可诱导氧化应激导致神经母细胞瘤细胞凋亡和抑制肿瘤生长。
TP1229	β-Amyloid (1-15) β-淀粉样蛋白 (1-15)	183745-81-5	99.88%
TP1229	β-Amyloid (1-15) (Amyloid β-Protein (1-15)) 是 β-淀粉样蛋白片段，可用于研究阿尔茨海默病。