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AIM2

Interferon-inducible protein AIM2 is a protein that in humans is encoded by the AIM2 gene. AIM2 is a cytoplasmic sensor found in hematopoietic cells that recognizes the presence of double-stranded DNA (dsDNA) of microbial or host cellular origin.AIM2-like receptor (ALR) family was founded on AIM2 and now consists of four members in human genome. Activated AIM2 recruits apoptosis-associated speck-like protein containing a CARD (ASC), resulting in caspase-1 binding, and forming of AIM2 inflammasome. This signaling contributes to the defense against bacterial and viral DNA.

Cat. No.	Product Name	CAS No.	Purity
T60404	NLRP3/AIM2-IN-2 化合物NLRP3/AIM2-IN-2	791840-86-3	99.67%
T60404	NLRP3/AIM2-IN-2是一种新型强效抑制剂，对依赖于 NLRP3和 AIM2炎症体的热扩散具有不同物种特异性影响，IC50为0.2392 ± 0.0233 μ M。
T77579	JC2-11 化合物JC2-11	937820-89-8	98.6%
T77579	JC2-11 是一种对炎症有抑制作用的化合物。JC2-11 对含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体有抑制作用，通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌...
T60442	NLRP3/AIM2-IN-3 化合物NLRP3/AIM2-IN-3	1787787-60-3	97.16%
T60442	NLRP3/AIM2-IN-3 是一种独特的分子，能以物种特异性的方式抑制 NLRP3 和 AIM2 炎性体的激活。它对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3是一种 NLRP3 和 AIM2 炎症体依赖性细胞裂解的强效抑制剂，对细胞裂解的 IC50 值为 0.077...