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Huntingtin

Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 gene. Mutated HTT is the cause of Huntington's disease (HD), and has been investigated for this role and also for its involvement in long-term memory storage. The exact function of this protein is not known, but it plays an important role in nerve cells. Within cells, huntingtin may or may not be involved in signaling, transporting materials, binding proteins and other structures, and protecting against apoptosis, a form of programmed cell death. The huntingtin protein is required for normal development before birth. It is expressed in many tissues in the body, with the highest levels of expression seen in the brain.

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure
T79717	MHTT-IN-2 化合物 mHTT-IN-2	2743336-70-9	98%
T79717	mHTT-IN-2（化合物27）作为mHTT的一种有效抑制剂，具有EC50值为0.066 μM，能够降低HTT RNA外显子[49-50]的规范剪接，从而调节HTT基因的剪接。在人类HD干细胞和BACHD小鼠模型上，mHTT-IN-2已显示出明显的体外及体内活性。此外，该化合物也被应用于研究与branaplam相关的周围...