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Amylin Receptor

The amylin receptors (AMYRs) are heterodimers of the calcitonin receptor that are bound to by amylin with high affinity and consist of AMY1, AMY2, and AMY3. Amylin mimetics that are agonists at the amylin receptors are being developed as therapies for diabetes and obesity. The AMY1 receptor may be activated by both amylin and the calcitonin gene-related peptide (CGRP) and could play a role in the effects of CGRP receptor antagonists developed for migraine. Dual agonists of the amylin and calcitonin receptors (DACRAs) are under development for obesity. Amylin and its receptors are believed to play a role in Alzheimer's disease.

Cat. No.	Product Name	CAS No.	Purity
TP2135L	CAC 253 acetate cAC 253醋酸盐	TP2135L	99.99%
TP2135L	cAC 253 acetate (TP2135 Free base) 是 amylin 的拮抗剂，抑制 125I-adrenomedullin 结合，其IC50 值为 25 nM。
T21581L	AC 187 Acetate 化合物AC 187 Acetate	T21581L	99.71%
T21581L	AC 187 Acetate 是胰淀素受体的强效拮抗剂。AC 187 对胰淀素受体的选择性高于降钙素和 CGRP 受体。
TP1232L	Amylin, amide, rat acetate(124447-81-0,free base) 化合物Amylin, amide, rat acetate	TP1232L	98.5%
TP1232L	Amylin, amide, rat acetate(124447-81-0,free base) 是 AMY1 和 AMY3 受体以及 AMY2 受体的强效和高亲和力配体。