首页Chromatin/EpigeneticEpigenetic Reader DomainARV-825
ARV-825
编号 T5434    
CAS 1818885-28-7     分子式 C46H47ClN8O9S     分子量 923.43
靶点: BRD4;
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.
规格 库存 单价 数量
2 mg 上海现货 799.00
5 mg 上海现货 1500.00
25 mg 上海现货 4223.00
1 mL * 10 mM (in DMSO) 上海现货 2346.00
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生物活性

产品描述

ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.

靶点活性

BRD4,

体外活性

ARV-825 more effectively suppresses c-MYC levels and downstream signaling than small molecule BRD4 inhibitors resulting in more effective cell proliferation inhibition and apoptosis induction in BL.In Burkitt’s lymphoma cells, ARV-825 reduces c-Myc levels, blocks cell proliferation, and induces apoptosis.

体内活性

细胞实验

Cells (50000/100ul) were seeded in 96-well tissue culture plates followed by addition of ARV-825 at indicated concentration. After 72 hours, 100 μL per well of reconstituted CellTiter-Glo reagent was added and read on Cytation 3 imaging reader. Relative cell growth was determined by comparing assay readings of treated cells with control DMSO treated cells. For apoptosis induction, Caspase-Glo 3/7 Assay was used following manufacturer s instruction.

化学信息

分子量

923.43

分子式

C46H47ClN8O9S

CAS

1818885-28-7

溶解度

DMSO: 50 mg/mL (54.15 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 1.083 ml 5.415 ml 10.829 ml
5 mM 0.217 ml 1.083 ml 2.166 ml
10 mM 0.108 ml 0.541 ml 1.083 ml
50 mM 0.022 ml 0.108 ml 0.217 ml
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