目录号 | 产品详情 | 靶点 | |
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T70962 | |||
MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) when compared with LNCaP (IC50, 0.97 μM) and PC3 cells (IC50, 5.12 μM). MHY219 showed a potent inhibition of total HDAC activity when compared with SAHA. MHY219 increased histone H3 hyperacetylation and reduced the expression of class I HDACs (1, 2 and 3) in prostate cancer cells. MHY219 effectively increased the sub-G1 fraction of cells through p21 and p27 dependent pathways in DU145 cells. MHY219 significantly induced a G2/M phase arrest in DU145 and PC3 cells and arrested the cell cycle at G0/G1 phase in LNCaP cells. Furthermore, MHY219 effectively increased apoptosis in DU145 and LNCaP cells, but not PC3 cells, according to Annexin V/PI staining and Western blot analysis. These results indicate that MHY219 is a potent HDAC inhibitor that targets regulating mu...... | |||
T80240 | |||
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2是一类具有生物活性的肽,作为蛋白酶激活受体1 (PAR-1) 的选择性激动剂,其特异性优于PAR-2。该肽通过HEK293细胞进行的基于细胞的钙信号传导测定确认了其对PAR-1的高特异性,并可用于研究PAR-1在体内的激活。PAR-1除了介导凝血酶的多种细胞作用外,还与PAR-4协作,参与调控凝血酶诱导的被分类为“凝血型”的肝细胞癌。 | |||
T22653 | Others | ||
5-HT1B full agonist | |||
T12476 | Dopamine Receptor | ||
Pimozide D4 is a deuterium labeled Pimozide. | |||
T70313 | |||
Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg. | |||
T79591 | VEGFR | ||
hCA/VEGFR-2-IN-4 (化合物15b) 是一种具有癌症治疗潜力的吲哚酮基苯磺酰胺类双重抑制剂,旨在抑制与癌症相关的hCA IX/XII 和VEGFR-2。该化合物对VEGFR-2具有较强的抑制能力(IC50=0.811 μM),并对hCAs展现高亲和性,其Ki值分别为hCA XII的3.8 nM,hCA IX的6.2 nM,hCA II的19.8 nM,以及hCA I的35.5 nM。此外,hCA/VEGFR-2-IN-4 对于VEGFR-2过表达的乳腺癌细胞有抗增殖作用。 | |||
T83936 | |||
LL-K9-3是一种基于选择性疏水标记技术(HyT)的CDK9-cyclin T1复合物降解剂(DC50值分别为cyclin T1的589 nM和CDK9的662 nM)。它由CDK9抑制剂SNS 032和一个糖基连接器连接到疏水标记组成。LL-K9-3不会降解其他CDKs(CDK1、2、4、5、6和7)。在22RV1细胞中,LL-K9-3通过诱导CDK9和cyclin T1的选择性和同步降解,降低雄激素受体(AR)和cMyc的表达。 | |||
T75611 | |||
Tibesaikosaponin V 是一种三萜双糖苷,可从北柴胡 (Bupleurum chinense DC) 的根的甲醇提取物中分离得到。Tibesaikosaponin V (TKV) 是一种三萜双糖苷,可从 Bupleurum chinense DC 根的甲醇提取物中分离得到。Tibesaikosaponin V 抑制脂质积累和甘油三酯含量的发生,对脂肪细胞没有细胞毒性。Tibesaikosaponin V 抑制核转录因子的 mRNA 表达,例如过氧化物酶体增殖物激活受体 γ (PPARγ) 和 CCAAT/增强子结合蛋白 α (C/EBPα)。Tibesaikosaponin V 抑制 3T3-L1 前脂肪细胞分化。Tibesaikosaponin V 可用于肥胖及其相关代谢紊乱的研究。 | |||
T38110 | |||
Galanin (Human) (Acetate)是一种含有30个氨基酸的神经肽和丙氨酸(GAL)受体激动剂。在表达重组人gal1受体的HEK293E 细胞(EC50= 0.031 nM)中,它抑制佛司可林诱导的cAMP 产生,并刺激表达重组人gal2受体的CHO 细胞(EC50= 12.3 nM)中肌醇磷酸的积累。Galanin (Human) (Acetate)诱导离体大鼠纵向眼底收缩,ec50值为13.8 nM。在大鼠福尔马林试验的第二阶段,鞘内给药人甘丙肽(3、10和30 nmol/只)可减少大鼠舔爪和退缩。 | |||
T61197 | |||
Irdabisant (CEP-26401) hydrochloride 是一种选择性、口服活性的组胺H3受体拮抗剂/逆激动剂,具备良好的血脑屏障渗透性。该化合物对大鼠和人类的H3受体具有高亲和力,其Ki值分别为7.2 nM和2.0 nM。此外,Irdabisant hydrochloride在抑制hERG电流方面表现出较低的活性,IC50为13.8 μM。在大鼠社会认知模型中,它展现了认知增强和唤醒的效果,可作为精神分裂症或认知障碍研究的潜在工具。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03739 | Transferrin Receptor/TFRC Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.5 kDa and the accession number is XP_005545315.1&NP_001244232.1.
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TMPY-01053 | Prolactin Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Prolactin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P16471-1.
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TMPY-01146 | Insulin Receptor Protein, Human, Recombinant (long isoform, His) | Human | HEK293 Cells | ||
Insulin Receptor Protein, Human, Recombinant (long isoform, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 107 kDa and the accession number is P06213-1.
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TMPY-01725 | Leptin Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Leptin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is P48357-1.
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TMPY-01873 | Transferrin Receptor/TFRC Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is AAA61153.1.
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TMPY-05096 | Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 103.6 kDa and the accession number is CAA25527.1.
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TMPY-02294 | Transferrin Receptor/TFRC Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.3 kDa and the accession number is Q62351.
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TMPY-06661 | Transferrin Receptor/TFRC Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.59 kDa and the accession number is Q99376.
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TMPY-02434 | Prolactin Receptor Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Prolactin Receptor Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P05710-1.
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TMPY-04395 | Insulin Receptor Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Insulin Receptor Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.3 kDa and the accession number is P06213-1.
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TMPK-01200 | Nogo Receptor/RTN4R Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes.
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TMPY-01149 | Insulin Receptor Protein, Human, Recombinant (short isoform, His) | Human | HEK293 Cells | ||
Insulin Receptor Protein, Human, Recombinant (short isoform, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 106 kDa and the accession number is P06213-2.
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TMPY-01612 | CD155/PVR Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
CD155/PVR Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.8 kDa and the accession number is Q0MSE6.
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TMPY-03144 | Nogo Receptor/RTN4R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Nogo Receptor/RTN4R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9BZR6.
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TMPY-02984 | Prolactin Receptor Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Prolactin Receptor Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P07321.
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TMPH-00932 | Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli | ||
Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
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TMPY-05025 | Thrombin Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Thrombin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is A0A024RAP7.
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TMPY-05283 | Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated | Human | HEK293 Cells | ||
Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 107 kDa and the accession number is P06213-1.
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TMPY-00874 | Leptin Receptor Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
Leptin Receptor Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 121.4 kDa and the accession number is P48357-1.
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TMPY-01566 | Prolactin Receptor Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
Prolactin Receptor Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.5 kDa and the accession number is Q08501-1.
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TMPY-02987 | Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells | ||
Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.28 kDa and the accession number is P48281.
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TMPY-01056 | Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 73 kDa and the accession number is Q9BZR6.
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TMPY-01163 | Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is Q99PI8.
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TMPY-02706 | Vitamin D Receptor/VDR Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Vitamin D Receptor/VDR Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P11473.
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TMPY-05274 | IL-23R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-23R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.3 kDa and the accession number is AAM44229.1.
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TMPY-04717 | CD122/IL2RB Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
CD122/IL2RB Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is H9Z8K1.
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TMPY-02934 | IL-2RG Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IL-2RG Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.5 kDa and the accession number is Q68FU6.
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TMPY-05102 | CD122/IL2RB Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CD122/IL2RB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is P26896.
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TMPJ-00154 | IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells) | Mouse | HEK293 Cells | ||
Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.
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TMPY-04649 | ROR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is Q01973.
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TMPJ-00994 | LTBR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
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TMPY-01221 | Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 73.8 kDa and the accession number is Q99PI8.
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TMPY-00085 | Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) | Human | HEK293 Cells | ||
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.1 kDa and the accession number is P30988-2.
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TMPY-03860 | Endothelin B Receptor Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Endothelin B Receptor Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34.4 kDa and the accession number is P24530-1.
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TMPY-00181 | Endothelin B Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Endothelin B Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 9.5 kDa and the accession number is P24530-1.
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TMPY-03951 | IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is F7H8F9.
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TMPY-06022 | FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A2K5UR19&NP_001181576.1.
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TMPY-01883 | EPOR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
EPOR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1.
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TMPY-00418 | IL-21R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-21R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is AAL82636.1.
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TMPY-04818 | EGFR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
EGFR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is A0A2K5WK39.
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TMPY-05617 | Transferrin Receptor/TFRC Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is P02786.
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TMPY-00317 | Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) | Human | HEK293 Cells | ||
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.9 kDa and the accession number is P30988-1.
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TMPY-05090 | CD25/IL2R alpha Protein, Rat, Recombinant (His) | Rat | Baculovirus Insect Cells | ||
CD25/IL2R alpha Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 25.9 kDa and the accession number is A6JLS0.
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TMPY-02335 | OSMR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
OSMR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accession number is O70458-1.
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TMPY-02824 | IL-18R alpha Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
IL-18R alpha Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5kDa and the accession number is A0A8I6A1C2.
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TMPY-03776 | CD25/IL2R alpha Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.4 kDa and the accession number is H6WS54.
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TMPY-03644 | CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.1 kDa and the accession number is H6WS54.
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TMPY-02286 | Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Matrix protein 1/M1 Protein (His) | H1N1 | E. coli | ||
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Matrix protein 1/M1 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 29.3 kDa and the accession number is B4UPA8.
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TMPJ-00335 | TGFBR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
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TMPY-05644 | CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated | Rhesus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.9 kDa and the accession number is Q5MNY4.
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