Topoisomerase (129) DNA Alkylation (24) Telomerase (17) DNA-PK (39) BMI-1 (6) DNA/RNA Synthesis (282) HDAC (134) DNA (17) PARP (110) CRISPR/Cas9 (7) DNA gyrase (14) Nucleoside Antimetabolite/Analog (74) DNA Alkylator/Crosslinker (30) MTH1 (6) DHFR (21) PPAR (163) Sirtuin (65) ATM/ATR (29) DUB (47)

TLR (75) NO Synthase (90) Thrombopoietin Receptor (3) CD73 (3) Reactive Oxygen Species (179) Cell wall (5) Pyroptosis (5) cGAS (5) IFNAR (10) MALT (6) gp120/CD4 (7) Arginase (8) NOS (114) Histamine Receptor (198) Galectin (5) Cytokine release (0) IL Receptor (192) Complement System (27) Aryl Hydrocarbon Receptor (25) CD38 (3) Immunology/Inflammation related (46) COX (363) MRP (26) LTR (27) PGE Synthase (15) Nrf2 (70) NOD-like Receptor (NLR) (17) CXCR (54) STING (21) NADPH-oxidase (36) Antiviral (56) AhR (22) NOD (24) ROS (123) IRAK (18) MyD88 (4) CCR (63) FLAP (6) PD-1/PD-L1 (24) FKBP (0) Interleukin (48) Prostaglandin Receptor (155)

STAT (121) ROCK (47) Porcupine (8) YAP (10) Casein Kinase (41) GSK-3 (78) Stemness kinase (1) Hippo pathway (4) Wnt/beta-catenin (105) TGF-beta/Smad (63) Smo (21) Gamma-secretase (39) JAK (138) Hedgehog/Smoothened (32)

Caspase (167) p53 (68) Necroptosis (1) ASK (8) Apoptosis (1164) TNF (238) RIP kinase (26) Mdm2 (32) IAP (19) PD-1/PD-L1 (24) c-RET (38) BCL (152) OXPHOS (4) FOXO1 (2) DAPK (4) Pyroptosis (5) Fas/FasL (3) FKBP (0) Survivin (5) PERK (18) Ferroptosis (107)

AChR (380) COX (363) NMU2R (1) P-gp (67) OX Receptor (21) AChE (101) Huntingtin (0) NMDAR (79) Norepinephrine (37) Beta-Secretase (16) Neuropeptide W (1) iGluR (81) Melanocortin Receptor (24) 5-HT Receptor (441) Gamma-secretase (39) Histamine Receptor (198) GlyT (10) BACE (32) Monoamine Oxidase (45) Neurokinin receptor (52) Adrenergic Receptor (296) FAAH (29) Dopamine Receptor (272) GluR (142) GABA Receptor (185) MT Receptor (7) CGRP Receptor (11) AAK1 (AP2 associated kinase 1) (3) Serotonin Transporter (40) MAO (73) Neuropeptide Y Receptor (37) P2Y Receptor (19) Opioid Receptor (122) CaMK (43) Adenylyl cyclase (8) Beta Amyloid (83) Adenosine Receptor (87) P2X Receptor (38) Imidazoline Receptor (10)

EGFR (225) Syk (33) JAK (138) FLT (107) VDA (2) HER (51) FGFR (93) BTK (56) Bcr-Abl (67) ALK (64) VEGFR (194) FAK (38) PDGFR (105) HIF (56) Src (108)

Histone Demethylase (59) HIF/HIF Prolyl-Hydroxylase (57) PARP (110) Pim (25) Histone Methyltransferase (144) Epigenetic Reader Domain (197) Sirtuin (65) HIF (56) JAK (138) DNA Methyltransferase (34) Aurora Kinase (68) Histone Acetyltransferase (31) AMPK (105) HDAC (134) PKC (130) Methionine Adenosyltransferase (MAT) (7) PAD (8)

IκB/IKK (72) Reactive Oxygen Species (179) NF-κB (374) RANKL/RANK (3) IRAK (18) NOD (24) RIP kinase (26)

Phosphorylase (10) GSNOR (1) Reductase (32) Acyltransferase (24) Transferase (52) NAMPT (11) Fatty Acid Synthase (40) LDL (22) Glucokinase (34) N-Acetylglucosaminyltransferase (1) Drug Metabolite (53) ROR (31) hCE (2) Angiotensin-converting Enzyme (ACE) (4) Mitochondrial Metabolism (60) Phosphatase (117) DHFR (21) Procollagen C Proteinase (1) Glutathione Peroxidase (21) PDE (181) NUDIX hydrolase (1) FXR (28) Carbonic Anhydrase (39) Reactive Oxygen Species (179) Thioredoxin (1) AhR (22) HIF/HIF Prolyl-Hydroxylase (57) HSP (83) Amino Acids and Derivatives (35) Hydrogenase (1) Stearoyl-CoA Desaturase (SCD) (12) Aminopeptidase (14) UGT (11) MAGL (6) P450 (206) Liver X Receptor (20) ATP Citrate Lyase (9) Lipase (22) HMG-CoA Reductase (25) Decarboxylase (6) PKM (8) Transaminase (2) PPAR (163) Acetyl-CoA Carboxylase (11) Lipid (13) Xanthine Oxidase (19) Taste receptor (2) Indoleamine 2,3-Dioxygenase (IDO) (23) transporter (38) NEDD8 (4) Retinoid Receptor (43) IDO (22) PAI-1 (11) Prolyl Endopeptidase (PREP) (2) Phospholipase (69) Isocitrate Dehydrogenase (IDH) (11) RAR/RXR  (5) Endogenous Metabolite (1177) NADPH (29) Dehydrogenase (162) Neprilysin (8) Calcium Channel (253) Casein Kinase (41) FABP (4) glycosidase (1) Hexokinase (3) SGK (10) Serine/threonin kinase (40) Factor Xa (18) stilbene oxidase (1) MAO (73) aconitase (1) FAAH (29) Lipoxygenase (68) CPT (0) CETP (13) Hydroxylase (22) Adenosine deaminase (5) Epoxide Hydrolase (19)

p97 (9) E1/E2/E3 Enzyme (50) DUB (47) Proteasome (75)

S6 Kinase (37) TOPK (7) Ras (86) ERK (167) MNK (7) Raf (87) KLF (3) MAPK (75) p38 MAPK (149) JNK (101) MLK (10) MEK (62)

Autophagy (914) LRRK2 (21) CXCR (54) lysosomal autophagy (2) Mitophagy (61) FKBP (0)

Proton pump (35) Chloride channel (32) CRM1 (8) Aquaporin (5) Calcium Channel (253) ABC (20) BCRP (11) Sodium Channel (169) VDAC (5) Monoamine Transporter (11) Na-K-Cl cotransporter (5) Anion Exchanger (1) NPC1L1 (7) Potassium Channel (227) iGluR (81) OCT (8) ATPase (94) P-gp (67) OAT (7) Monocarboxylate transporter (10) Na+/Ca2+ Exchanger (8) Piezo Channel (2) CFTR (19) GABA Receptor (185) TRP/TRPV Channel (129) HCN Channel (1) P2X Receptor (38)

Dynamin (8) Integrin (59) HSP (83) PKC (130) Gap Junction Protein (12) Microtubule Associated (139) Myosin (12) Akt (168) Bcr-Abl (67) ROCK (47) FAK (38) Wnt/beta-catenin (105) Arp2/3 Complex (1) PAK (18) Kinesin (30)

Integrase (5) Reverse Transcriptase (43) RSV (17) Antibiotic (596) SARS-CoV (92) Influenza Virus (157) HIV Protease (281) Antifungal (295) GluCls (3) ribosome (36) HBV (74) Virus Protease (75) Parasite (296) CCR (63) HSV (80) Antifection (421) Anti-infection (67) Antibacterial (1001) HCV Protease (111)

Oxytocin Receptor (8) Estrogen/progestogen Receptor (127) Androgen Receptor (92) Thyroid hormone receptor(THR) (32) GPR (114) Estrogen Receptor/ERR (106) Glucocorticoid Receptor (77) RAAS (104) Opioid Receptor (122) Aromatase (18) Reductase (32) LHRH (2)

Protease (1) Proteasome (75) Caspase (167) DPP-4 (26) Prolyl Endopeptidase (PREP) (2) HCV Protease (111) Carboxypeptidase (7) Thrombin (33) Tyrosinase (93) Glutaminase (6) MMP (117) HIV Protease (281) Gamma-secretase (39) Cysteine Protease (49) Serine Protease (41)

Src (108) PDGFR (105) TAM Receptor (39) c-Fms (30) PYK2 (6) Syk (33) FAK (38) PKA (59) CSF-1R (15) ALK (64) Tie-2 (7) ROS Kinase (11) ACK (5) DYRK (18) Discoidin Domain Receptor (DDR) (12) FGFR (93) EGFR (225) FLT (107) Bcr-Abl (67) Hck (4) BTK (56) HER (51) Ephrin Receptor (14) c-Met/HGFR (80) VEGFR (194) c-RET (38) IGF-1R (47) Trk receptor (41) c-Kit (81) Tyrosine Kinases (49)

Decarboxylase (6) Progesterone Receptor (28) Platelet aggregation (20) CYP19A1 (1) Others (15522) Fer/FerT kinase (1) advanced glycation end products (4) DprE1 (5)

Free radical scavengers (13) GST (10) Antioxidant (143) CAT (9) Glutathione reductase (3) GPX (5)

Pim (25) HER (51) STAT (121) JAK (138) EGFR (225)

PI3K (247) DNA-PK (39) PTEN (9) Akt (168) PI4K (15) S6 Kinase (37) mTOR (119) ATM/ATR (29) GSK-3 (78) PDK (22) AMPK (105) SIK (6) MELK (7)

PD-1/PD-L1 (24) PLK (30) ROCK (47) Rho (24) KSP (4) DHFR (21) IRE1 (15) DUB (47) Wee1 (5) Chk (34) Aurora Kinase (68) c-Myc (25) DYRK (18) Haspin Kinase (2) BMI-1 (6) LIM Kinase (8) Antifolate (19) cell cycle arrest (4) Ferroptosis (107) APC (7) Serine/threonin kinase (40) Nucleoside Antimetabolite/Analog (74) DNA/RNA Synthesis (282) CDK (266)

Melanocortin Receptor (24) Prostaglandin Receptor (155) Histamine Receptor (198) Adenosine Receptor (87) Neuropeptide Y Receptor (37) Melatonin Receptor (9) Bombesin Receptor (11) LPL Receptor (36) GHSR (16) Amylin Receptor (3) GPCR19 (14) Endothelin Receptor (23) TSH Receptor (4) Protease-activated Receptor (32) Hedgehog/Smoothened (32) Neurokinin receptor (52) OX Receptor (21) Glucagon Receptor (45) PAFR (38) Neuropeptide W (1) CGRP Receptor (11) GTPase (14) LPA Receptor (19) Neurotensin Receptor (14) CXCR (54) CaSR (13) Adrenergic Receptor (296) Ras (86) 5-HT Receptor (441) CRFR (15) Adiponectin receptor (4) Apelin receptor (8) Motilin Receptor (2) P2Y Receptor (19) GPR (114) Somatostatin (12) Sigma receptor (32) EBI2/GPR183 (3) Cannabinoid Receptor (63) Guanylate cyclase (20) Bradykinin Receptor (18) cAMP (36) Leukotriene Receptor (17) Dopamine Receptor (272) Oxytocin Receptor (8) Vasopressin Receptor (20) Annexin A (7) GNRH Receptor (22) cholecystokinin (19) SGLT (29) S1P Receptor (41) GRK (11) Melanin-concentrating Hormone Receptor (MCHR) (8) Opioid Receptor (122)