小分子抑制剂

小分子抑制剂是一类能够与靶蛋白结合并能降低靶蛋白生物活性的小分子化合物, 包括各类酶抑制剂、 转录因子抑制剂、代谢通路抑制剂、质子泵抑制剂、离子通道阻断剂等等。 这些小分子抑制剂在精细调控细胞生命和功能方面具有显著优势,使其成为近年来生命科学研究中重要的工具药。 陶术生物可提供10000+种小分子抑制剂,涉及了肿瘤、糖尿病、内分泌系统、神经系统、心血管疾病、代谢等8个重点研究领域, 覆盖了PI3K-AKT-mTOR、GPCR/G Protein、MAPK、Apoptosis等25条热门信号通路,包含300多个靶点,700多个亚型,且每月持续的更新中。 可用于信号通路研究、药物作用机制研究、造模等工具药,满足您的科研需求。

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信号通路

  血管生成   凋亡   自噬   细胞周期   表观遗传   细胞骨架   DNA损伤和修复   内分泌与激素   G蛋白偶联受体   免疫与炎症   JAK/STAT信号通路   MAPK信号通路   离子通道   代谢   微生物学   神经科学   NF-Kb信号通路   氧化还原   PI3K/Akt/mTOR信号通路   蛋白酶体   干细胞   蛋白酪氨酸激酶   泛素化   其他

Angiogenesis

Apoptosis

Autophagy

Cell Cycle/Checkpoint

Chromatin/Epigenetic

Cytoskeletal Signaling

DNA Damage/DNA Repair

Endocrinology/Hormones

GPCR/G Protein

Immunology/Inflammation

JAK/STAT signaling

MAPK

Membrane transporter/Ion channel

Metabolism

Microbiology/Virology

Neuroscience

NF-Κb

oxidation-reduction

PI3K/Akt/mTOR signaling

Proteases/Proteasome

Stem Cells

Tyrosine Kinase/Adaptors

Ubiquitination

Others

ACAT ( 8) advanced glycation end pr... ( 4) Decarboxylase ( 6) DprE1 ( 4) Others ( 14987) Platelet aggregation ( 6) Wnk ( 2) BVDV ( 0) Keap1-Nrf ( 1) NKCC ( 0) Salt-Inducible Kinase ( 0) PTP1B ( 0) Progesterone Receptor ( 1) Thyroid Hormone Receptor ( 1) Fer/FerT kinase ( 0) CYP19A1 ( 0) Cathepsin B ( 0) PGK ( 2) Streptokinase ( 34) Hepatitis C virus NS3 pro... ( 1) Vaccinia virus ( 1) High-affinity choline tra... ( 1) Genome polyprotein ( 1) Epstein-Barr nuclear anti... ( 1) Vesicular stomatitis viru... ( 1) Ataxin ( 174) 3C-like protease ( 1) Autoinducer 1 sensor kina... ( 1) Human immunodeficiency vi... ( 5) Human herpesvirus 1 strai... ( 1) Voltage-gated potassium c... ( 1) Malme-3M ( 1) Serotonin 2a (5-HT2a) rec... ( 1) Saccharomyces cerevisiae ( 2) Enoyl-acyl carrier reduct... ( 2) Putative uncharacterized ... ( 1) Egl nine homolog 3 ( 1) Paracentrotus lividus ( 1) SNB-75 ( 1) Candida albicans ( 1) NIH3T3 ( 1) Muscarinic acetylcholine ... ( 1) Cytochrome P450 2D6 ( 1) Ubiquitin-conjugating enz... ( 1) Staphylococcus aureus ( 3) Giardia ( 2) Putative fructose-1,6-bis... ( 2) Trypanosoma brucei rhodes... ( 1) Cannabinoid CB2 receptor ( 1) Trypanosoma brucei brucei ( 6) Toxoplasma gondii RH ( 1) Glycine transporter 2 ( 1) Relaxin receptor 1 ( 1) Phosphoglycerate kinase, ... ( 8) Nucleic Acid ( 2) ORF 73 ( 1) Large T antigen ( 4) Human parainfluenza virus... ( 1) Phosphotyrosine-protein p... ( 1) Enoyl-[acyl-carrier-prote... ( 1) Streptokinase A ( 21) Mycobacterium bovis BCG ( 4) Shiga toxin ( 2) HL-60 ( 1) INS1 ( 1) Smoothened homolog ( 1) Casein kinase I delta ( 0) Isoprenylcysteine carboxy... ( 1) Phosphodiesterase 6D ( 1) Excitatory amino acid tra... ( 1) Heat shock factor protein... ( 1) Sentrin-specific protease... ( 1) Phosphodiesterase 10A ( 1) Tyrosine-protein kinase S... ( 0) Formyl peptide receptor 1 ( 2) Transient receptor potent... ( 2) Macrophage migration inhi... ( 1) Intestinal alkaline phosp... ( 2) Cytochrome P450 17A1 ( 1) Butyrylcholinesterase ( 2) Zinc finger protein GLI1 ( 1) Heparanase ( 1) 1-acylglycerol-3-phosphat... ( 1) Voltage-gated T-type calc... ( 2) DNA dC->dU-editing enzyme... ( 2) Kappa opioid receptor ( 1) Fructose-bisphosphate ald... ( 1) Cytochrome P450 3A4 ( 2) Estrogen receptor alpha ( 2) Voltage-gated T-type calc... ( 3) C-C chemokine receptor ty... ( 2) A498 ( 1) MRC5 ( 2) Trace amine-associated re... ( 4) MDA-MB-468 ( 1) MCF7 ( 1) Prostaglandin E synthase ( 2) Fatty acid transport prot... ( 1) Flap endonuclease 1 ( 2) Matrix metalloproteinase-... ( 1) Nociceptin receptor ( 1) Long-chain fatty acid tra... ( 1) Glycogen synthase kinase-... ( 0) SF-539 ( 1) Peripheral-type benzodiaz... ( 1) HeLa ( 2) SK-BR-3 ( 1) Thioredoxin reductase 1, ... ( 5) Mus musculus ( 2) Tumour suppressor p53/onc... ( 1) Neutrophils ( 2) Breast cancer type 1 susc... ( 6) Alpha-synuclein ( 5) SNB-19 ( 1) No relevant target ( 2) HepG2 ( 4) RAW264.7 ( 2) Menin/Histone-lysine N-me... ( 15) UO-31 ( 1) DNA polymerase eta ( 6) Paired box protein Pax-8 ( 2) DNA dC->dU-editing enzyme... ( 18) Mitogen-activated protein... ( 1) A549 ( 1) DNA polymerase iota ( 36) Cavia porcellus ( 3) Tankyrase-2 ( 2) Plasmodium falciparum ( 419) Protein-glutamine gamma-g... ( 1) Cytochrome P450 19A1 ( 2) MOLT-4 ( 1) Leukocyte elastase ( 1) Xanthine dehydrogenase ( 1) RXF 393 ( 2) SK-MEL-2 ( 1) Cytochrome P450 2C9 ( 2) ATP-dependent molecular c... ( 5) Phosphodiesterase 5A ( 2) T98G ( 4) PI3-kinase p110-alpha sub... ( 0) Isocitrate dehydrogenase ... ( 5) Cyclooxygenase-2 ( 2) MIF/CD74 (Macrophage migr... ( 1) Runt-related transcriptio... ( 5) GABA-A receptor; anion ch... ( 0) Cytochrome P450 2C19 ( 2) NCI-H460 ( 1) OVCAR-5 ( 1) Vascular endothelial grow... ( 0) Aorta ( 2) Ubiquitin carboxyl-termin... ( 1) Vero ( 1) Prostanoid EP2 receptor ( 1) Peptidyl-prolyl cis-trans... ( 1) TAR DNA-binding protein 4... ( 202) Cytochrome P450 1A2 ( 5) Mothers against decapenta... ( 435) Fibroblast growth factor ... ( 1) microRNA 21 ( 105) Luciferin 4-monooxygenase ( 35) FAD-linked sulfhydryl oxi... ( 9) Signal transducer and act... ( 1) XF498 ( 2) PI3-kinase p110-delta sub... ( 0) HEK293 ( 557) Histone-lysine N-methyltr... ( 4) Monoamine oxidase B ( 5) Estradiol 17-beta-dehydro... ( 1) Tyrosine-protein kinase A... ( 0) Estrogen receptor beta ( 1) Aldo-keto-reductase famil... ( 2) Neurokinin 3 receptor ( 4) Cytochrome P450 11B2 ( 1) Sigma-1 receptor ( 2) Sigma opioid receptor ( 1) Endothelin-converting enz... ( 1) Testis-specific androgen-... ( 2) Anthrax lethal factor ( 9) Kinesin-like protein 1 ( 2) Peroxisome proliferator-a... ( 1) Tyrosyl-DNA phosphodieste... ( 3) Serotonin 2c (5-HT2c) rec... ( 4) Niemann-Pick C1 protein ( 17) Serotonin 6 (5-HT6) recep... ( 14) Ras-related protein Rab-9... ( 26) Adenosine A1 receptor ( 3) Adenosylmethionine-8-amin... ( 2) Inosine-5'-monophosphate ... ( 1) Bromodomain adjacent to z... ( 11) Lysine-specific demethyla... ( 0) G-protein coupled recepto... ( 1) Dopamine D2 receptor ( 3) Glutaminase kidney isofor... ( 5) Lipoxin A4 receptor ( 3) Arachidonate 15-lipoxygen... ( 2) Melanin-concentrating hor... ( 1) Aberrant vpr protein ( 23) Elongation of very long c... ( 1) Alkaline phosphatase, tis... ( 3) Beta-glucocerebrosidase ( 22) Alpha-galactosidase A ( 5) Nonstructural protein 1 ( 136) Vanilloid receptor ( 2) Metabotropic glutamate re... ( 8) 6-phospho-1-fructokinase ( 0) Neuropeptide S receptor ( 14) 4'-phosphopantetheinyl tr... ( 5) Tumor susceptibility gene... ( 3) Lysine-specific demethyla... ( 2) MAP kinase ERK2 ( 1) FK506 binding protein 12 ( 124) P-glycoprotein 1 ( 5) ATP-dependent DNA helicas... ( 9) Endoplasmic reticulum-ass... ( 7) Ecdysone receptor ( 1) Cholesteryl ester transfe... ( 2) Huntingtin ( 77) Lethal(3)malignant brain ... ( 10) 15-hydroxyprostaglandin d... ( 10) Short transient receptor ... ( 19) Transcriptional regulator... ( 5) Aldehyde dehydrogenase di... ( 1) ATP-dependent Clp proteas... ( 111) Thioredoxin glutathione r... ( 24) Cellular tumor antigen p5... ( 560) Cannabinoid CB1 receptor ( 8) ATP-binding cassette sub-... ( 1) Aldehyde dehydrogenase 1A... ( 58) TGF-beta receptor type II ( 2) Histone acetyltransferase... ( 25) Glucagon-like peptide 1 r... ( 213) Glycoprotein hormones alp... ( 110) Tyrosine-protein kinase r... ( 1) Survival motor neuron pro... ( 73) Histone-lysine N-methyltr... ( 68) Microtubule-associated pr... ( 613) Prelamin-A/C ( 542) Lysosomal alpha-glucosida... ( 42) Geminin ( 246) Arachidonate 15-lipoxygen... ( 5) Epoxide hydratase ( 3) Beta-2 adrenergic recepto... ( 6) Inositol monophosphatase ... ( 111) Thyroid hormone receptor ... ( 314) Thyroid stimulating hormo... ( 50) Dihydrofolate reductase ( 1) G protein-coupled recepto... ( 4) Beta-lactamase AmpC ( 613) Ataxin-2 ( 215) Hypoxia-inducible factor ... ( 4) Nuclear factor erythroid ... ( 389) Cruzipain ( 33) Guanine nucleotide-bindin... ( 164) Serine-protein kinase ATM ( 2) Pyruvate kinase isozymes ... ( 2) Nuclear receptor ROR-gamm... ( 140) ATPase family AAA domain-... ( 113) C-X-C chemokine receptor ... ( 3)
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