Angiogenesis
ALK (
62)
Bcr-Abl (
68)
BTK (
48)
EGFR (
202)
FAK (
28)
FGFR (
76)
FLT (
97)
HER (
33)
HIF (
42)
JAK (
116)
PDGFR (
85)
Src (
95)
Syk (
27)
VDA (
2)
VEGFR (
166)
Apoptosis
Apoptosis inducer (
6)
ASK (
6)
BCL (
135)
Caspase (
147)
c-RET (
33)
Ferroptosis (
13)
FOXO1 (
2)
IAP (
16)
Mdm2 (
35)
p53 (
59)
PD-1/PD-L1 (
13)
PERK (
12)
Survivin (
5)
TNF (
226)
Fas/FasL (
2)
Apoptosis (
154)
RIP kinase (
5)
OXPHOS (
4)
Autophagy
Cell Cycle/Checkpoint
APC (
6)
Aurora Kinase (
55)
BMI-1 (
6)
CDK (
231)
cell cycle arrest (
4)
Chk (
32)
c-Myc (
23)
DHFR (
18)
DNA/RNA Synthesis (
335)
DYRK (
38)
Ferroptosis (
13)
KSP (
4)
LIM Kinase (
9)
Nucleoside Antimetabolite... (
21)
PD-1/PD-L1 (
13)
PLK (
74)
Rho (
20)
ROCK (
41)
Serine/threonin kinase (
20)
Wee1 (
3)
Haspin Kinase (
3)
Deubiquitinase (
5)
Antifolate (
4)
IRE1 (
9)
Chromatin/Epigenetic
Aurora Kinase (
55)
DNA Methyltransferase (
24)
Epigenetic Reader Domain (
170)
HDAC (
115)
HIF (
42)
HIF/HIF Prolyl-Hydroxylas... (
11)
Histone Demethylase (
57)
Histone Methyltransferase (
231)
JAK (
116)
PARP (
86)
Pim (
24)
PKC (
109)
Sirtuin (
47)
Histone Acetyltransferase (
76)
MicroRNA (
3)
Histone Acetylation (
1)
PAD (
7)
Cytoskeletal Signaling
Akt (
140)
Bcr-Abl (
68)
Dynamin (
6)
FAK (
28)
Gap Junction Protein (
9)
HSP (
69)
Integrin (
49)
Kinesin (
25)
Microtubule Associated (
97)
PAK (
15)
PKC (
109)
ROCK (
41)
Wnt/beta-catenin (
75)
Arp2/3 Complex (
0)
Myosin (
3)
DNA Damage/DNA Repair
ATM/ATR (
61)
BMI-1 (
6)
DHFR (
18)
DNA (
6)
DNA Alkylation (
34)
DNA gyrase (
14)
DNA/RNA Synthesis (
335)
DNA-PK (
37)
HDAC (
115)
MTH1 (
8)
Nucleoside Antimetabolite... (
21)
PARP (
86)
PPAR (
140)
Sirtuin (
47)
Telomerase (
13)
Topoisomerase (
110)
DNA Alkylator/Crosslinker (
3)
Deubiquitinase (
5)
Endocrinology/Hormones
Androgen Receptor (
83)
Aromatase (
15)
Estrogen/progestogen Rece... (
124)
Glucocorticoid Receptor (
71)
GPR (
87)
LHRH (
2)
Opioid Receptor (
101)
RAAS (
94)
Reductase (
29)
Thyroid hormone receptor(... (
25)
Estrogen Receptor/ERR (
15)
Oxytocin Receptor (
6)
GPCR/G Protein
5-HT Receptor (
385)
Adenosine Receptor (
41)
Adiponectin receptor (
3)
Adrenergic Receptor (
251)
Annexin A (
5)
Bombesin Receptor (
6)
Bradykinin Receptor (
13)
cAMP (
34)
Cannabinoid Receptor (
47)
CaSR (
7)
cholecystokinin (
12)
CXCR (
48)
Dopamine Receptor (
229)
Endothelin Receptor (
18)
Glucagon Receptor (
26)
GNRH Receptor (
22)
GPCR19 (
13)
GPR (
87)
GRK (
9)
GTPase (
9)
Hedgehog/Smoothened (
24)
Histamine Receptor (
154)
LPA Receptor (
13)
Melatonin Receptor (
2)
Neurokinin receptor (
35)
Opioid Receptor (
101)
OX Receptor (
20)
PAFR (
39)
Prostaglandin Receptor (
113)
Protease-activated Recept... (
26)
Ras (
49)
S1P Receptor (
36)
SGLT (
26)
Sigma receptor (
25)
Somatostatin (
4)
Vasopressin Receptor (
14)
GHSR (
13)
Melanocortin Receptor (
18)
Neurotensin Receptor (
7)
Motilin Receptor (
1)
Melanin-concentrating Hor... (
4)
Neuropeptide Y Receptor (
17)
Leukotriene Receptor (
2)
EBI2/GPR183 (
3)
TSH Receptor (
4)
Oxytocin Receptor (
6)
Guanylate cyclase (
7)
CRFR (
4)
Apelin receptor (
1)
Immunology/Inflammation
AhR (
21)
Antiviral (
48)
Arginase (
8)
CCR (
48)
Cell wall (
5)
COX (
307)
CXCR (
48)
gp120/CD4 (
8)
Histamine Receptor (
154)
IL Receptor (
180)
Immunology & Inflammation... (
94)
LTR (
27)
MALT (
5)
MRP (
22)
NADPH-oxidase (
34)
NOD (
23)
NOS (
112)
Nrf2 (
46)
PD-1/PD-L1 (
13)
PGE Synthase (
5)
Prostaglandin Receptor (
113)
ROS (
136)
TLR (
57)
Complement System (
10)
MyD88 (
1)
STING (
14)
NO Synthase (
25)
Thrombopoietin Receptor (
3)
NOD-like Receptor (NLR) (
1)
IRAK (
7)
Interleukin Related (
0)
Interleukin Related (
5)
Immunology & Inflammation... (
0)
FLAP (
3)
Cytokine release (
0)
Aryl Hydrocarbon Receptor (
5)
Reactive Oxygen Species (
4)
IFNAR (
2)
JAK/STAT signaling
MAPK
ERK (
248)
JNK (
104)
MAPK (
90)
MEK (
54)
MLK (
9)
MNK (
6)
p38 MAPK (
123)
Raf (
78)
Ras (
49)
S6 Kinase (
31)
TOPK (
5)
Membrane transporter/Ion channel
ABC (
14)
ATPase (
88)
Calcium Channel (
193)
CFTR (
16)
CGRP Receptor (
7)
Chloride channel (
25)
CRM1 (
8)
GABA Receptor (
161)
Monoamine Transporter (
9)
Monocarboxylate transport... (
8)
Na-K-Cl cotransporter (
3)
NPC1L1 (
7)
OAT (
5)
OCT (
6)
P-gp (
44)
Potassium Channel (
169)
Proton pump (
21)
Sodium Channel (
128)
TRP/TRPV Channel (
95)
Anion Exchanger (
1)
VDAC (
3)
P2X Receptor (
1)
Na+/Ca2+ Exchanger (
2)
iGluR (
11)
HCN Channel (
1)
BCRP (
4)
Aquaporin (
2)
Metabolism
Acetyl-CoA Carboxylase (
10)
AhR (
21)
Amino Acids and Derivativ... (
24)
Aminopeptidase (
8)
ATP Citrate Lyase (
6)
Calcium Channel (
193)
Carbonic Anhydrase (
33)
Carboxypeptidase(CPG2) (
3)
Casein Kinase (
37)
CETP (
11)
Decarboxylase (
6)
Dehydrogenase (
127)
DHFR (
18)
FAAH (
21)
Factor Xa (
16)
Fatty Acid Synthase (
28)
FXR (
24)
Glucokinase (
91)
GR (
8)
GSNOR (
1)
HIF/HIF Prolyl-Hydroxylas... (
11)
HMG-CoA Reductase (
23)
HSP (
69)
Hydrogenase (
1)
Hydroxylase (
18)
IDO (
29)
LDL (
22)
Lipase (
16)
Lipid (
10)
Lipoxygenase (
50)
Liver X Receptor (
18)
MAO (
67)
MPO (
7)
NADPH (
20)
NAMPT (
10)
P450 (
157)
PAI-1 (
6)
PDE (
149)
PED (
2)
Phosphatase (
70)
Phospholipase (
46)
Phosphorylase (
8)
PKM (
85)
PPAR (
140)
Procollagen C Proteinase (
1)
RAR/RXR (
2)
Reductase (
29)
Retinoid Receptor (
31)
ROR (
21)
Serine/threonin kinase (
20)
SGK (
8)
Thioredoxin (
1)
Transferase (
37)
transporter (
30)
UGT (
11)
Vitamin (
55)
CPT (
1)
FABP (
4)
hCE (
0)
N-Acetylglucosaminyltrans... (
1)
Transaminase (
2)
Endogenous Metabolite (
345)
Xanthine Oxidase (
8)
Mitochondrial Metabolism (
17)
hCE(human carboxylesteras... (
0)
glycosidase (
0)
aconitase (
1)
Epoxide Hydrolase (
1)
Acyltransferase (
8)
Neprilysin (
5)
Electron transport (
2)
stilbene oxidase (
2)
Stearoyl-CoA Desaturase (... (
1)
Reactive Oxygen Species (
4)
NEDD8 (
1)
MAGL (
2)
Isocitrate Dehydrogenase ... (
2)
Indoleamine 2,3-Dioxygena... (
2)
Hexokinase (
5)
Glutathione Peroxidase (
5)
Adenosine deaminase (
1)
Microbiology/Virology
Antibacterial (
350)
Antibiotic (
199)
Antifection (
471)
Antifungal (
107)
CCR (
48)
GluCls (
3)
HBV (
44)
HCV Protease (
83)
HIV Protease (
171)
HSV (
40)
Influenza Virus (
52)
Integrase (
5)
Reverse Transcriptase (
20)
ribosome (
35)
Parasite (
70)
Anti-infection (
18)
RSV (
6)
SARS-CoV (
13)
Virus Protease (
3)
Bacterial (
1)
Neuroscience
5-HT Receptor (
385)
AChR (
386)
Adrenergic Receptor (
251)
BACE (
30)
Beta Amyloid (
56)
CaMK (
28)
COX (
307)
Dopamine Receptor (
229)
FAAH (
21)
GABA Receptor (
161)
Gamma-secretase (
28)
GluR (
114)
GlyT (
8)
Histamine Receptor (
154)
MAO (
67)
Neurokinin receptor (
35)
NMDAR (
64)
Norepinephrine (
36)
Opioid Receptor (
101)
OX Receptor (
20)
P2 Receptor (
47)
P-gp (
44)
Beta-Secretase (
2)
MT Receptor (
7)
Melanocortin Receptor (
18)
Neuropeptide Y Receptor (
17)
AChE (
6)
Serotonin Transporter (
10)
NMU2R (
1)
Monoamine Oxidase (
3)
iGluR (
11)
Adenylyl cyclase (
2)
NF-Κb
oxidation-reduction
Antioxidant (
120)
CAT (
9)
Free radical scavengers (
7)
Glutathione reductase (
3)
GPX (
4)
GST (
6)
PI3K/Akt/mTOR signaling
Akt (
140)
AMPK (
72)
ATM/ATR (
61)
DNA-PK (
37)
GSK-3 (
72)
MELK (
6)
mTOR (
104)
PDK (
17)
PI3K (
226)
PTEN (
5)
S6 Kinase (
31)
SIK (
4)
PI4K (
5)
Proteases/Proteasome
Acetyl-CoA Carboxylase (
10)
ATP Citrate Lyase (
6)
Caspase (
147)
Cysteine Protease (
42)
DPP-4 (
24)
Gamma-secretase (
28)
Glutaminase (
3)
HCV Protease (
83)
HIV Protease (
171)
MMP (
90)
Proteasome (
41)
Serine Protease (
32)
Thrombin (
34)
Tyrosinase (
80)
Acyltransferase (
8)
Stem Cells
Casein Kinase (
37)
Gamma-secretase (
28)
GSK-3 (
72)
Hedgehog/Smoothened (
24)
Hippo pathway (
4)
JAK (
116)
Porcupine (
5)
ROCK (
41)
STAT (
95)
TGF-beta/Smad (
35)
Wnt/beta-catenin (
75)
YAP (
1)
TACC (
2)
Stemness kinase (
1)
Smo (
5)
Tyrosine Kinase/Adaptors
ACK (
4)
ALK (
62)
Bcr-Abl (
68)
BTK (
48)
c-Fms (
20)
c-Kit (
70)
c-Met/HGFR (
72)
c-RET (
33)
CSF-1R (
13)
DYRK (
38)
EGFR (
202)
Ephrin Receptor (
10)
FAK (
28)
FGFR (
76)
FLT (
97)
Hck (
3)
HER (
33)
IGF-1R (
31)
PDGFR (
85)
PKA (
52)
PYK2 (
5)
Src (
95)
Syk (
27)
TAM Receptor (
36)
Tie-2 (
7)
Trk receptor (
35)
Tyrosine Kinases (
46)
VEGFR (
166)
Discoidin Domain Receptor... (
7)
Ubiquitination
Others
ACAT (
8)
advanced glycation end pr... (
4)
Decarboxylase (
6)
DprE1 (
4)
Others (
15154)
Platelet aggregation (
7)
Wnk (
2)
BVDV (
0)
Keap1-Nrf (
1)
NKCC (
1)
Salt-Inducible Kinase (
0)
PTP1B (
0)
Progesterone Receptor (
1)
Thyroid Hormone Receptor (
1)
Fer/FerT kinase (
0)
CYP19A1 (
0)
Cathepsin B (
0)
PGK (
2)
Streptokinase (
34)
Hepatitis C virus NS3 pro... (
1)
Vaccinia virus (
1)
High-affinity choline tra... (
1)
Genome polyprotein (
1)
Epstein-Barr nuclear anti... (
1)
Vesicular stomatitis viru... (
1)
Ataxin (
174)
3C-like protease (
1)
Autoinducer 1 sensor kina... (
1)
Human immunodeficiency vi... (
5)
Human herpesvirus 1 strai... (
1)
Voltage-gated potassium c... (
1)
Malme-3M (
1)
Serotonin 2a (5-HT2a) rec... (
1)
Saccharomyces cerevisiae (
2)
Enoyl-acyl carrier reduct... (
2)
Putative uncharacterized ... (
1)
Egl nine homolog 3 (
1)
Paracentrotus lividus (
1)
SNB-75 (
1)
Candida albicans (
1)
NIH3T3 (
1)
Muscarinic acetylcholine ... (
1)
Cytochrome P450 2D6 (
1)
Ubiquitin-conjugating enz... (
1)
Staphylococcus aureus (
3)
Giardia (
2)
Putative fructose-1,6-bis... (
2)
Trypanosoma brucei rhodes... (
1)
Cannabinoid CB2 receptor (
1)
Trypanosoma brucei brucei (
6)
Toxoplasma gondii RH (
1)
Glycine transporter 2 (
1)
Relaxin receptor 1 (
1)
Phosphoglycerate kinase, ... (
8)
Nucleic Acid (
2)
ORF 73 (
1)
Large T antigen (
4)
Human parainfluenza virus... (
1)
Phosphotyrosine-protein p... (
1)
Enoyl-[acyl-carrier-prote... (
1)
Streptokinase A (
21)
Mycobacterium bovis BCG (
4)
Shiga toxin (
2)
HL-60 (
1)
INS1 (
1)
Smoothened homolog (
1)
Casein kinase I delta (
0)
Isoprenylcysteine carboxy... (
1)
Phosphodiesterase 6D (
1)
Excitatory amino acid tra... (
1)
Heat shock factor protein... (
1)
Sentrin-specific protease... (
1)
Phosphodiesterase 10A (
1)
Tyrosine-protein kinase S... (
0)
Formyl peptide receptor 1 (
2)
Transient receptor potent... (
2)
Macrophage migration inhi... (
1)
Intestinal alkaline phosp... (
2)
Cytochrome P450 17A1 (
1)
Butyrylcholinesterase (
2)
Zinc finger protein GLI1 (
1)
Heparanase (
1)
1-acylglycerol-3-phosphat... (
1)
Voltage-gated T-type calc... (
2)
DNA dC->dU-editing enzyme... (
2)
Kappa opioid receptor (
1)
Fructose-bisphosphate ald... (
1)
Cytochrome P450 3A4 (
2)
Estrogen receptor alpha (
2)
Voltage-gated T-type calc... (
3)
C-C chemokine receptor ty... (
2)
A498 (
1)
MRC5 (
2)
Trace amine-associated re... (
4)
MDA-MB-468 (
1)
MCF7 (
1)
Prostaglandin E synthase (
2)
Fatty acid transport prot... (
1)
Flap endonuclease 1 (
2)
Matrix metalloproteinase-... (
1)
Nociceptin receptor (
1)
Long-chain fatty acid tra... (
1)
Glycogen synthase kinase-... (
0)
SF-539 (
1)
Peripheral-type benzodiaz... (
1)
HeLa (
2)
SK-BR-3 (
1)
Thioredoxin reductase 1, ... (
5)
Mus musculus (
2)
Tumour suppressor p53/onc... (
1)
Neutrophils (
2)
Breast cancer type 1 susc... (
6)
Alpha-synuclein (
5)
SNB-19 (
1)
No relevant target (
2)
HepG2 (
4)
RAW264.7 (
2)
Menin/Histone-lysine N-me... (
15)
UO-31 (
1)
DNA polymerase eta (
6)
Paired box protein Pax-8 (
2)
DNA dC->dU-editing enzyme... (
18)
Mitogen-activated protein... (
1)
A549 (
1)
DNA polymerase iota (
36)
Cavia porcellus (
3)
Tankyrase-2 (
2)
Plasmodium falciparum (
419)
Protein-glutamine gamma-g... (
1)
Cytochrome P450 19A1 (
2)
MOLT-4 (
1)
Leukocyte elastase (
1)
Xanthine dehydrogenase (
1)
RXF 393 (
2)
SK-MEL-2 (
1)
Cytochrome P450 2C9 (
2)
ATP-dependent molecular c... (
5)
Phosphodiesterase 5A (
2)
T98G (
4)
PI3-kinase p110-alpha sub... (
0)
Isocitrate dehydrogenase ... (
5)
Cyclooxygenase-2 (
2)
MIF/CD74 (Macrophage migr... (
1)
Runt-related transcriptio... (
5)
GABA-A receptor; anion ch... (
0)
Cytochrome P450 2C19 (
2)
NCI-H460 (
1)
OVCAR-5 (
1)
Vascular endothelial grow... (
0)
Aorta (
2)
Ubiquitin carboxyl-termin... (
1)
Vero (
1)
Prostanoid EP2 receptor (
1)
Peptidyl-prolyl cis-trans... (
1)
TAR DNA-binding protein 4... (
202)
Cytochrome P450 1A2 (
5)
Mothers against decapenta... (
435)
Fibroblast growth factor ... (
1)
microRNA 21 (
105)
Luciferin 4-monooxygenase (
35)
FAD-linked sulfhydryl oxi... (
9)
Signal transducer and act... (
1)
XF498 (
2)
PI3-kinase p110-delta sub... (
0)
HEK293 (
557)
Histone-lysine N-methyltr... (
4)
Monoamine oxidase B (
5)
Estradiol 17-beta-dehydro... (
1)
Tyrosine-protein kinase A... (
0)
Estrogen receptor beta (
1)
Aldo-keto-reductase famil... (
2)
Neurokinin 3 receptor (
4)
Cytochrome P450 11B2 (
1)
Sigma-1 receptor (
2)
Sigma opioid receptor (
1)
Endothelin-converting enz... (
1)
Testis-specific androgen-... (
2)
Anthrax lethal factor (
9)
Kinesin-like protein 1 (
2)
Peroxisome proliferator-a... (
1)
Tyrosyl-DNA phosphodieste... (
3)
Serotonin 2c (5-HT2c) rec... (
4)
Niemann-Pick C1 protein (
17)
Serotonin 6 (5-HT6) recep... (
14)
Ras-related protein Rab-9... (
26)
Adenosine A1 receptor (
3)
Adenosylmethionine-8-amin... (
2)
Inosine-5'-monophosphate ... (
1)
Bromodomain adjacent to z... (
11)
Lysine-specific demethyla... (
0)
G-protein coupled recepto... (
1)
Dopamine D2 receptor (
3)
Glutaminase kidney isofor... (
5)
Lipoxin A4 receptor (
3)
Arachidonate 15-lipoxygen... (
2)
Melanin-concentrating hor... (
1)
Aberrant vpr protein (
23)
Elongation of very long c... (
1)
Alkaline phosphatase, tis... (
3)
Beta-glucocerebrosidase (
22)
Alpha-galactosidase A (
5)
Nonstructural protein 1 (
136)
Vanilloid receptor (
2)
Metabotropic glutamate re... (
8)
6-phospho-1-fructokinase (
0)
Neuropeptide S receptor (
14)
4'-phosphopantetheinyl tr... (
5)
Tumor susceptibility gene... (
3)
Lysine-specific demethyla... (
2)
MAP kinase ERK2 (
1)
FK506 binding protein 12 (
124)
P-glycoprotein 1 (
5)
ATP-dependent DNA helicas... (
9)
Endoplasmic reticulum-ass... (
7)
Ecdysone receptor (
1)
Cholesteryl ester transfe... (
2)
Huntingtin (
77)
Lethal(3)malignant brain ... (
10)
15-hydroxyprostaglandin d... (
10)
Short transient receptor ... (
19)
Transcriptional regulator... (
5)
Aldehyde dehydrogenase di... (
1)
ATP-dependent Clp proteas... (
111)
Thioredoxin glutathione r... (
24)
Cellular tumor antigen p5... (
560)
Cannabinoid CB1 receptor (
8)
ATP-binding cassette sub-... (
1)
Aldehyde dehydrogenase 1A... (
58)
TGF-beta receptor type II (
2)
Histone acetyltransferase... (
25)
Glucagon-like peptide 1 r... (
213)
Glycoprotein hormones alp... (
110)
Tyrosine-protein kinase r... (
1)
Survival motor neuron pro... (
73)
Histone-lysine N-methyltr... (
68)
Microtubule-associated pr... (
613)
Prelamin-A/C (
542)
Lysosomal alpha-glucosida... (
42)
Geminin (
246)
Arachidonate 15-lipoxygen... (
5)
Epoxide hydratase (
3)
Beta-2 adrenergic recepto... (
6)
Inositol monophosphatase ... (
111)
Thyroid hormone receptor ... (
314)
Thyroid stimulating hormo... (
50)
Dihydrofolate reductase (
1)
G protein-coupled recepto... (
4)
Beta-lactamase AmpC (
613)
Ataxin-2 (
215)
Hypoxia-inducible factor ... (
4)
Nuclear factor erythroid ... (
389)
Cruzipain (
33)
Guanine nucleotide-bindin... (
164)
Serine-protein kinase ATM (
2)
Pyruvate kinase isozymes ... (
2)
Nuclear receptor ROR-gamm... (
140)
ATPase family AAA domain-... (
113)
C-X-C chemokine receptor ... (
3)