小分子抑制剂

ALK ( 60) Bcr-Abl ( 66) BTK ( 47) EGFR ( 195) FAK ( 27) FGFR ( 74) FLT ( 90) HER ( 32) HIF ( 41) JAK ( 113) PDGFR ( 82) Src ( 92) Syk ( 26) VDA ( 2) VEGFR ( 161)

Apoptosis inducer ( 6) ASK ( 5) BCL ( 138) Caspase ( 143) c-RET ( 33) Ferroptosis ( 12) FOXO1 ( 2) IAP ( 15) Mdm2 ( 34) p53 ( 57) PD-1/PD-L1 ( 12) PERK ( 11) Survivin ( 4) TNF ( 223) Fas/FasL ( 2) Apoptosis ( 117) RIP kinase ( 4) OXPHOS ( 4)

Autophagy ( 169) CXCR ( 48) LRRK2 ( 21) lysosomal autophagy ( 2) Mitophagy ( 5)

APC ( 2) Aurora Kinase ( 53) BMI-1 ( 6) CDK ( 219) cell cycle arrest ( 4) Chk ( 30) c-Myc ( 22) DHFR ( 18) DNA/RNA Synthesis ( 325) DYRK ( 37) Ferroptosis ( 12) KSP ( 3) LIM Kinase ( 9) Nucleoside Antimetabolite... ( 18) PD-1/PD-L1 ( 12) PLK ( 74) Rho ( 19) ROCK ( 39) Serine/threonin kinase ( 19) Wee1 ( 3) Haspin Kinase ( 3) Deubiquitinase ( 4) Antifolate ( 3) IRE1 ( 7)

Aurora Kinase ( 53) DNA Methyltransferase ( 23) Epigenetic Reader Domain ( 162) HDAC ( 114) HIF ( 41) HIF/HIF Prolyl-Hydroxylas... ( 10) Histone Demethylase ( 57) Histone Methyltransferase ( 225) JAK ( 113) PARP ( 81) Pim ( 23) PKC ( 106) Sirtuin ( 45) Histone Acetyltransferase ( 76) MicroRNA ( 3) Histone Acetylation ( 1) PAD ( 6)

Akt ( 131) Bcr-Abl ( 66) Dynamin ( 5) FAK ( 27) Gap Junction Protein ( 9) HSP ( 68) Integrin ( 45) Kinesin ( 22) Microtubule Associated ( 92) PAK ( 14) PKC ( 106) ROCK ( 39) Wnt/beta-catenin ( 72) Arp2/3 Complex ( 0) Myosin ( 3)

ATM/ATR ( 61) BMI-1 ( 6) DHFR ( 18) DNA ( 6) DNA Alkylation ( 32) DNA gyrase ( 14) DNA/RNA Synthesis ( 325) DNA-PK ( 34) HDAC ( 114) MTH1 ( 7) Nucleoside Antimetabolite... ( 18) PARP ( 81) PPAR ( 132) Sirtuin ( 45) Telomerase ( 13) Topoisomerase ( 107) DNA Alkylator/Crosslinker ( 2) Deubiquitinase ( 4)

Androgen Receptor ( 77) Aromatase ( 15) Estrogen/progestogen Rece... ( 121) Glucocorticoid Receptor ( 69) GPR ( 79) LHRH ( 1) Opioid Receptor ( 97) RAAS ( 91) Reductase ( 28) Thyroid hormone receptor(... ( 23) Estrogen Receptor/ERR ( 7) Oxytocin Receptor ( 6)

5-HT Receptor ( 366) Adenosine Receptor ( 38) Adiponectin receptor ( 3) Adrenergic Receptor ( 237) Annexin A ( 5) Bombesin Receptor ( 4) Bradykinin Receptor ( 12) cAMP ( 35) Cannabinoid Receptor ( 43) CaSR ( 7) cholecystokinin ( 11) CXCR ( 48) Dopamine Receptor ( 212) Endothelin Receptor ( 18) Glucagon Receptor ( 24) GNRH Receptor ( 20) GPCR19 ( 13) GPR ( 79) GRK ( 9) GTPase ( 7) Hedgehog/Smoothened ( 21) Histamine Receptor ( 147) LPA Receptor ( 13) Melatonin Receptor ( 2) Neurokinin receptor ( 34) Opioid Receptor ( 97) OX Receptor ( 19) PAFR ( 40) Prostaglandin Receptor ( 112) Protease-activated Recept... ( 25) Ras ( 46) S1P Receptor ( 33) SGLT ( 26) Sigma receptor ( 23) Somatostatin ( 4) Vasopressin Receptor ( 14) GHSR ( 12) Melanocortin Receptor ( 16) Neurotensin Receptor ( 7) Motilin Receptor ( 1) Melanin-concentrating Hor... ( 4) Neuropeptide Y Receptor ( 16) Leukotriene Receptor ( 1) EBI2/GPR183 ( 3) TSH Receptor ( 4) Oxytocin Receptor ( 6) Guanylate cyclase ( 7) CRFR ( 4) Apelin receptor ( 1)

AhR ( 21) Antiviral ( 44) Arginase ( 7) CCR ( 45) Cell wall ( 5) COX ( 300) CXCR ( 48) gp120/CD4 ( 8) Histamine Receptor ( 147) IL Receptor ( 177) Immunology & Inflammation... ( 92) LTR ( 27) MALT ( 5) MRP ( 21) NADPH-oxidase ( 34) NOD ( 22) NOS ( 112) Nrf2 ( 46) PD-1/PD-L1 ( 12) PGE Synthase ( 5) Prostaglandin Receptor ( 112) ROS ( 130) TLR ( 56) Complement System ( 10) MyD88 ( 1) STING ( 13) NO Synthase ( 18) Thrombopoietin Receptor ( 3) NOD-like Receptor (NLR) ( 1) IRAK ( 6) Interleukin Related ( 0) Interleukin Related ( 4) Immunology & Inflammation... ( 0) FLAP ( 3) Cytokine release ( 0) Aryl Hydrocarbon Receptor ( 4) Reactive Oxygen Species ( 4) IFNAR ( 1)

EGFR ( 195) HER ( 32) JAK ( 113) Pim ( 23) STAT ( 91)

ERK ( 247) JNK ( 103) MAPK ( 82) MEK ( 50) MLK ( 10) MNK ( 5) p38 MAPK ( 120) Raf ( 75) Ras ( 46) S6 Kinase ( 29) TOPK ( 4)

ABC ( 14) ATPase ( 87) Calcium Channel ( 190) CFTR ( 15) CGRP Receptor ( 8) Chloride channel ( 23) CRM1 ( 8) GABA Receptor ( 152) Monoamine Transporter ( 9) Monocarboxylate transport... ( 8) Na-K-Cl cotransporter ( 3) NPC1L1 ( 7) OAT ( 4) OCT ( 5) P-gp ( 39) Potassium Channel ( 165) Proton pump ( 20) Sodium Channel ( 122) TRP/TRPV Channel ( 87) Anion Exchanger ( 1) VDAC ( 3) P2X Receptor ( 1) Na+/Ca2+ Exchanger ( 1) iGluR ( 7) HCN Channel ( 1) BCRP ( 4) Aquaporin ( 2)

Acetyl-CoA Carboxylase ( 9) AhR ( 21) Amino Acids and Derivativ... ( 24) Aminopeptidase ( 7) ATP Citrate Lyase ( 6) Calcium Channel ( 190) Carbonic Anhydrase ( 32) Carboxypeptidase(CPG2) ( 3) Casein Kinase ( 35) CETP ( 11) Decarboxylase ( 6) Dehydrogenase ( 122) DHFR ( 18) FAAH ( 20) Factor Xa ( 16) Fatty Acid Synthase ( 27) FXR ( 24) Glucokinase ( 89) GR ( 8) GSNOR ( 1) HIF/HIF Prolyl-Hydroxylas... ( 10) HMG-CoA Reductase ( 20) HSP ( 68) Hydrogenase ( 1) Hydroxylase ( 17) IDO ( 29) LDL ( 22) Lipase ( 14) Lipid ( 10) Lipoxygenase ( 50) Liver X Receptor ( 19) MAO ( 64) MPO ( 7) NADPH ( 20) NAMPT ( 10) P450 ( 147) PAI-1 ( 6) PDE ( 137) PED ( 2) Phosphatase ( 61) Phospholipase ( 42) Phosphorylase ( 8) PKM ( 85) PPAR ( 132) Procollagen C Proteinase ( 1) RAR/RXR ( 2) Reductase ( 28) Retinoid Receptor ( 29) ROR ( 20) Serine/threonin kinase ( 19) SGK ( 6) Thioredoxin ( 1) Transferase ( 34) transporter ( 28) UGT ( 10) Vitamin ( 53) CPT ( 1) FABP ( 4) hCE ( 0) N-Acetylglucosaminyltrans... ( 1) Transaminase ( 2) Endogenous Metabolite ( 289) Xanthine Oxidase ( 7) Mitochondrial Metabolism ( 17) hCE(human carboxylesteras... ( 0) glycosidase ( 0) aconitase ( 1) Epoxide Hydrolase ( 1) Acyltransferase ( 5) Neprilysin ( 5) Electron transport ( 2) stilbene oxidase ( 2) Stearoyl-CoA Desaturase (... ( 1) Reactive Oxygen Species ( 4) NEDD8 ( 1) MAGL ( 1) Isocitrate Dehydrogenase ... ( 1) Indoleamine 2,3-Dioxygena... ( 2) Hexokinase ( 5) Glutathione Peroxidase ( 2) Adenosine deaminase ( 1)

Antibacterial ( 308) Antibiotic ( 186) Antifection ( 476) Antifungal ( 95) CCR ( 45) GluCls ( 3) HBV ( 41) HCV Protease ( 76) HIV Protease ( 165) HSV ( 37) Influenza Virus ( 47) Integrase ( 5) Reverse Transcriptase ( 19) ribosome ( 34) Parasite ( 54) Anti-infection ( 5) RSV ( 5) SARS-CoV ( 12) Virus Protease ( 1) Bacterial ( 0)

5-HT Receptor ( 366) AChR ( 368) Adrenergic Receptor ( 237) BACE ( 29) Beta Amyloid ( 53) CaMK ( 28) COX ( 300) Dopamine Receptor ( 212) FAAH ( 20) GABA Receptor ( 152) Gamma-secretase ( 27) GluR ( 109) GlyT ( 7) Histamine Receptor ( 147) MAO ( 64) Neurokinin receptor ( 34) NMDAR ( 53) Norepinephrine ( 34) Opioid Receptor ( 97) OX Receptor ( 19) P2 Receptor ( 44) P-gp ( 39) Beta-Secretase ( 2) MT Receptor ( 6) Melanocortin Receptor ( 16) Neuropeptide Y Receptor ( 16) AChE ( 5) Serotonin Transporter ( 7) NMU2R ( 1) Monoamine Oxidase ( 3) iGluR ( 7) Adenylyl cyclase ( 1)

IκB/IKK ( 66) NF-κB ( 276) NOD ( 22) RIP kinase ( 4) IRAK ( 6) Reactive Oxygen Species ( 4)

Antioxidant ( 119) CAT ( 9) Free radical scavengers ( 7) Glutathione reductase ( 3) GPX ( 4) GST ( 5)

Akt ( 131) AMPK ( 71) ATM/ATR ( 61) DNA-PK ( 34) GSK-3 ( 70) MELK ( 5) mTOR ( 101) PDK ( 17) PI3K ( 221) PTEN ( 5) S6 Kinase ( 29) SIK ( 4) PI4K ( 3)

Acetyl-CoA Carboxylase ( 9) ATP Citrate Lyase ( 6) Caspase ( 143) Cysteine Protease ( 40) DPP-4 ( 21) Gamma-secretase ( 27) Glutaminase ( 3) HCV Protease ( 76) HIV Protease ( 165) MMP ( 90) Proteasome ( 38) Serine Protease ( 32) Thrombin ( 31) Tyrosinase ( 81) Acyltransferase ( 5)

Casein Kinase ( 35) Gamma-secretase ( 27) GSK-3 ( 70) Hedgehog/Smoothened ( 21) Hippo pathway ( 4) JAK ( 113) Porcupine ( 5) ROCK ( 39) STAT ( 91) TGF-beta/Smad ( 34) Wnt/beta-catenin ( 72) YAP ( 1) TACC ( 2) Stemness kinase ( 1) Smo ( 4)

ACK ( 4) ALK ( 60) Bcr-Abl ( 66) BTK ( 47) c-Fms ( 20) c-Kit ( 70) c-Met/HGFR ( 70) c-RET ( 33) CSF-1R ( 13) DYRK ( 37) EGFR ( 195) Ephrin Receptor ( 10) FAK ( 27) FGFR ( 74) FLT ( 90) Hck ( 3) HER ( 32) IGF-1R ( 27) PDGFR ( 82) PKA ( 48) PYK2 ( 5) Src ( 92) Syk ( 26) TAM Receptor ( 34) Tie-2 ( 7) Trk receptor ( 34) Tyrosine Kinases ( 45) VEGFR ( 161) Discoidin Domain Receptor... ( 7)

DUB ( 34) E2 conjugating ( 0) p97 ( 7) Proteasome ( 38) E1/E2/E3 Enzyme ( 16)

ACAT ( 8) advanced glycation end pr... ( 4) Decarboxylase ( 6) DprE1 ( 4) Others ( 15110) Platelet aggregation ( 7) Wnk ( 2) BVDV ( 0) Keap1-Nrf ( 1) NKCC ( 1) Salt-Inducible Kinase ( 0) PTP1B ( 0) Progesterone Receptor ( 1) Thyroid Hormone Receptor ( 1) Fer/FerT kinase ( 0) CYP19A1 ( 0) Cathepsin B ( 0) PGK ( 2) Streptokinase ( 34) Hepatitis C virus NS3 pro... ( 1) Vaccinia virus ( 1) High-affinity choline tra... ( 1) Genome polyprotein ( 1) Epstein-Barr nuclear anti... ( 1) Vesicular stomatitis viru... ( 1) Ataxin ( 174) 3C-like protease ( 1) Autoinducer 1 sensor kina... ( 1) Human immunodeficiency vi... ( 5) Human herpesvirus 1 strai... ( 1) Voltage-gated potassium c... ( 1) Malme-3M ( 1) Serotonin 2a (5-HT2a) rec... ( 1) Saccharomyces cerevisiae ( 2) Enoyl-acyl carrier reduct... ( 2) Putative uncharacterized ... ( 1) Egl nine homolog 3 ( 1) Paracentrotus lividus ( 1) SNB-75 ( 1) Candida albicans ( 1) NIH3T3 ( 1) Muscarinic acetylcholine ... ( 1) Cytochrome P450 2D6 ( 1) Ubiquitin-conjugating enz... ( 1) Staphylococcus aureus ( 3) Giardia ( 2) Putative fructose-1,6-bis... ( 2) Trypanosoma brucei rhodes... ( 1) Cannabinoid CB2 receptor ( 1) Trypanosoma brucei brucei ( 6) Toxoplasma gondii RH ( 1) Glycine transporter 2 ( 1) Relaxin receptor 1 ( 1) Phosphoglycerate kinase, ... ( 8) Nucleic Acid ( 2) ORF 73 ( 1) Large T antigen ( 4) Human parainfluenza virus... ( 1) Phosphotyrosine-protein p... ( 1) Enoyl-[acyl-carrier-prote... ( 1) Streptokinase A ( 21) Mycobacterium bovis BCG ( 4) Shiga toxin ( 2) HL-60 ( 1) INS1 ( 1) Smoothened homolog ( 1) Casein kinase I delta ( 0) Isoprenylcysteine carboxy... ( 1) Phosphodiesterase 6D ( 1) Excitatory amino acid tra... ( 1) Heat shock factor protein... ( 1) Sentrin-specific protease... ( 1) Phosphodiesterase 10A ( 1) Tyrosine-protein kinase S... ( 0) Formyl peptide receptor 1 ( 2) Transient receptor potent... ( 2) Macrophage migration inhi... ( 1) Intestinal alkaline phosp... ( 2) Cytochrome P450 17A1 ( 1) Butyrylcholinesterase ( 2) Zinc finger protein GLI1 ( 1) Heparanase ( 1) 1-acylglycerol-3-phosphat... ( 1) Voltage-gated T-type calc... ( 2) DNA dC->dU-editing enzyme... ( 2) Kappa opioid receptor ( 1) Fructose-bisphosphate ald... ( 1) Cytochrome P450 3A4 ( 2) Estrogen receptor alpha ( 2) Voltage-gated T-type calc... ( 3) C-C chemokine receptor ty... ( 2) A498 ( 1) MRC5 ( 2) Trace amine-associated re... ( 4) MDA-MB-468 ( 1) MCF7 ( 1) Prostaglandin E synthase ( 2) Fatty acid transport prot... ( 1) Flap endonuclease 1 ( 2) Matrix metalloproteinase-... ( 1) Nociceptin receptor ( 1) Long-chain fatty acid tra... ( 1) Glycogen synthase kinase-... ( 0) SF-539 ( 1) Peripheral-type benzodiaz... ( 1) HeLa ( 2) SK-BR-3 ( 1) Thioredoxin reductase 1, ... ( 5) Mus musculus ( 2) Tumour suppressor p53/onc... ( 1) Neutrophils ( 2) Breast cancer type 1 susc... ( 6) Alpha-synuclein ( 5) SNB-19 ( 1) No relevant target ( 2) HepG2 ( 4) RAW264.7 ( 2) Menin/Histone-lysine N-me... ( 15) UO-31 ( 1) DNA polymerase eta ( 6) Paired box protein Pax-8 ( 2) DNA dC->dU-editing enzyme... ( 18) Mitogen-activated protein... ( 1) A549 ( 1) DNA polymerase iota ( 36) Cavia porcellus ( 3) Tankyrase-2 ( 2) Plasmodium falciparum ( 419) Protein-glutamine gamma-g... ( 1) Cytochrome P450 19A1 ( 2) MOLT-4 ( 1) Leukocyte elastase ( 1) Xanthine dehydrogenase ( 1) RXF 393 ( 2) SK-MEL-2 ( 1) Cytochrome P450 2C9 ( 2) ATP-dependent molecular c... ( 5) Phosphodiesterase 5A ( 2) T98G ( 4) PI3-kinase p110-alpha sub... ( 0) Isocitrate dehydrogenase ... ( 5) Cyclooxygenase-2 ( 2) MIF/CD74 (Macrophage migr... ( 1) Runt-related transcriptio... ( 5) GABA-A receptor; anion ch... ( 0) Cytochrome P450 2C19 ( 2) NCI-H460 ( 1) OVCAR-5 ( 1) Vascular endothelial grow... ( 0) Aorta ( 2) Ubiquitin carboxyl-termin... ( 1) Vero ( 1) Prostanoid EP2 receptor ( 1) Peptidyl-prolyl cis-trans... ( 1) TAR DNA-binding protein 4... ( 202) Cytochrome P450 1A2 ( 5) Mothers against decapenta... ( 435) Fibroblast growth factor ... ( 1) microRNA 21 ( 105) Luciferin 4-monooxygenase ( 35) FAD-linked sulfhydryl oxi... ( 9) Signal transducer and act... ( 1) XF498 ( 2) PI3-kinase p110-delta sub... ( 0) HEK293 ( 557) Histone-lysine N-methyltr... ( 4) Monoamine oxidase B ( 5) Estradiol 17-beta-dehydro... ( 1) Tyrosine-protein kinase A... ( 0) Estrogen receptor beta ( 1) Aldo-keto-reductase famil... ( 2) Neurokinin 3 receptor ( 4) Cytochrome P450 11B2 ( 1) Sigma-1 receptor ( 2) Sigma opioid receptor ( 1) Endothelin-converting enz... ( 1) Testis-specific androgen-... ( 2) Anthrax lethal factor ( 9) Kinesin-like protein 1 ( 2) Peroxisome proliferator-a... ( 1) Tyrosyl-DNA phosphodieste... ( 3) Serotonin 2c (5-HT2c) rec... ( 4) Niemann-Pick C1 protein ( 17) Serotonin 6 (5-HT6) recep... ( 14) Ras-related protein Rab-9... ( 26) Adenosine A1 receptor ( 3) Adenosylmethionine-8-amin... ( 2) Inosine-5'-monophosphate ... ( 1) Bromodomain adjacent to z... ( 11) Lysine-specific demethyla... ( 0) G-protein coupled recepto... ( 1) Dopamine D2 receptor ( 3) Glutaminase kidney isofor... ( 5) Lipoxin A4 receptor ( 3) Arachidonate 15-lipoxygen... ( 2) Melanin-concentrating hor... ( 1) Aberrant vpr protein ( 23) Elongation of very long c... ( 1) Alkaline phosphatase, tis... ( 3) Beta-glucocerebrosidase ( 22) Alpha-galactosidase A ( 5) Nonstructural protein 1 ( 136) Vanilloid receptor ( 2) Metabotropic glutamate re... ( 8) 6-phospho-1-fructokinase ( 0) Neuropeptide S receptor ( 14) 4'-phosphopantetheinyl tr... ( 5) Tumor susceptibility gene... ( 3) Lysine-specific demethyla... ( 2) MAP kinase ERK2 ( 1) FK506 binding protein 12 ( 124) P-glycoprotein 1 ( 5) ATP-dependent DNA helicas... ( 9) Endoplasmic reticulum-ass... ( 7) Ecdysone receptor ( 1) Cholesteryl ester transfe... ( 2) Huntingtin ( 77) Lethal(3)malignant brain ... ( 10) 15-hydroxyprostaglandin d... ( 10) Short transient receptor ... ( 19) Transcriptional regulator... ( 5) Aldehyde dehydrogenase di... ( 1) ATP-dependent Clp proteas... ( 111) Thioredoxin glutathione r... ( 24) Cellular tumor antigen p5... ( 560) Cannabinoid CB1 receptor ( 8) ATP-binding cassette sub-... ( 1) Aldehyde dehydrogenase 1A... ( 58) TGF-beta receptor type II ( 2) Histone acetyltransferase... ( 25) Glucagon-like peptide 1 r... ( 213) Glycoprotein hormones alp... ( 110) Tyrosine-protein kinase r... ( 1) Survival motor neuron pro... ( 73) Histone-lysine N-methyltr... ( 68) Microtubule-associated pr... ( 613) Prelamin-A/C ( 542) Lysosomal alpha-glucosida... ( 42) Geminin ( 246) Arachidonate 15-lipoxygen... ( 5) Epoxide hydratase ( 3) Beta-2 adrenergic recepto... ( 6) Inositol monophosphatase ... ( 111) Thyroid hormone receptor ... ( 314) Thyroid stimulating hormo... ( 50) Dihydrofolate reductase ( 1) G protein-coupled recepto... ( 4) Beta-lactamase AmpC ( 613) Ataxin-2 ( 215) Hypoxia-inducible factor ... ( 4) Nuclear factor erythroid ... ( 389) Cruzipain ( 33) Guanine nucleotide-bindin... ( 164) Serine-protein kinase ATM ( 2) Pyruvate kinase isozymes ... ( 2) Nuclear receptor ROR-gamm... ( 140) ATPase family AAA domain-... ( 113) C-X-C chemokine receptor ... ( 3)