小分子抑制剂

ALK ( 62) Bcr-Abl ( 68) BTK ( 48) EGFR ( 202) FAK ( 28) FGFR ( 76) FLT ( 97) HER ( 33) HIF ( 42) JAK ( 116) PDGFR ( 85) Src ( 95) Syk ( 27) VDA ( 2) VEGFR ( 166)

Apoptosis inducer ( 6) ASK ( 6) BCL ( 135) Caspase ( 147) c-RET ( 33) Ferroptosis ( 13) FOXO1 ( 2) IAP ( 16) Mdm2 ( 35) p53 ( 59) PD-1/PD-L1 ( 13) PERK ( 12) Survivin ( 5) TNF ( 226) Fas/FasL ( 2) Apoptosis ( 154) RIP kinase ( 5) OXPHOS ( 4)

Autophagy ( 180) CXCR ( 48) LRRK2 ( 20) lysosomal autophagy ( 2) Mitophagy ( 5)

APC ( 6) Aurora Kinase ( 55) BMI-1 ( 6) CDK ( 231) cell cycle arrest ( 4) Chk ( 32) c-Myc ( 23) DHFR ( 18) DNA/RNA Synthesis ( 335) DYRK ( 38) Ferroptosis ( 13) KSP ( 4) LIM Kinase ( 9) Nucleoside Antimetabolite... ( 21) PD-1/PD-L1 ( 13) PLK ( 74) Rho ( 20) ROCK ( 41) Serine/threonin kinase ( 20) Wee1 ( 3) Haspin Kinase ( 3) Deubiquitinase ( 5) Antifolate ( 4) IRE1 ( 9)

Aurora Kinase ( 55) DNA Methyltransferase ( 24) Epigenetic Reader Domain ( 170) HDAC ( 115) HIF ( 42) HIF/HIF Prolyl-Hydroxylas... ( 11) Histone Demethylase ( 57) Histone Methyltransferase ( 231) JAK ( 116) PARP ( 86) Pim ( 24) PKC ( 109) Sirtuin ( 47) Histone Acetyltransferase ( 76) MicroRNA ( 3) Histone Acetylation ( 1) PAD ( 7)

Akt ( 140) Bcr-Abl ( 68) Dynamin ( 6) FAK ( 28) Gap Junction Protein ( 9) HSP ( 69) Integrin ( 49) Kinesin ( 25) Microtubule Associated ( 97) PAK ( 15) PKC ( 109) ROCK ( 41) Wnt/beta-catenin ( 75) Arp2/3 Complex ( 0) Myosin ( 3)

ATM/ATR ( 61) BMI-1 ( 6) DHFR ( 18) DNA ( 6) DNA Alkylation ( 34) DNA gyrase ( 14) DNA/RNA Synthesis ( 335) DNA-PK ( 37) HDAC ( 115) MTH1 ( 8) Nucleoside Antimetabolite... ( 21) PARP ( 86) PPAR ( 140) Sirtuin ( 47) Telomerase ( 13) Topoisomerase ( 110) DNA Alkylator/Crosslinker ( 3) Deubiquitinase ( 5)

Androgen Receptor ( 83) Aromatase ( 15) Estrogen/progestogen Rece... ( 124) Glucocorticoid Receptor ( 71) GPR ( 87) LHRH ( 2) Opioid Receptor ( 101) RAAS ( 94) Reductase ( 29) Thyroid hormone receptor(... ( 25) Estrogen Receptor/ERR ( 15) Oxytocin Receptor ( 6)

5-HT Receptor ( 385) Adenosine Receptor ( 41) Adiponectin receptor ( 3) Adrenergic Receptor ( 251) Annexin A ( 5) Bombesin Receptor ( 6) Bradykinin Receptor ( 13) cAMP ( 34) Cannabinoid Receptor ( 47) CaSR ( 7) cholecystokinin ( 12) CXCR ( 48) Dopamine Receptor ( 229) Endothelin Receptor ( 18) Glucagon Receptor ( 26) GNRH Receptor ( 22) GPCR19 ( 13) GPR ( 87) GRK ( 9) GTPase ( 9) Hedgehog/Smoothened ( 24) Histamine Receptor ( 154) LPA Receptor ( 13) Melatonin Receptor ( 2) Neurokinin receptor ( 35) Opioid Receptor ( 101) OX Receptor ( 20) PAFR ( 39) Prostaglandin Receptor ( 113) Protease-activated Recept... ( 26) Ras ( 49) S1P Receptor ( 36) SGLT ( 26) Sigma receptor ( 25) Somatostatin ( 4) Vasopressin Receptor ( 14) GHSR ( 13) Melanocortin Receptor ( 18) Neurotensin Receptor ( 7) Motilin Receptor ( 1) Melanin-concentrating Hor... ( 4) Neuropeptide Y Receptor ( 17) Leukotriene Receptor ( 2) EBI2/GPR183 ( 3) TSH Receptor ( 4) Oxytocin Receptor ( 6) Guanylate cyclase ( 7) CRFR ( 4) Apelin receptor ( 1)

AhR ( 21) Antiviral ( 48) Arginase ( 8) CCR ( 48) Cell wall ( 5) COX ( 307) CXCR ( 48) gp120/CD4 ( 8) Histamine Receptor ( 154) IL Receptor ( 180) Immunology & Inflammation... ( 94) LTR ( 27) MALT ( 5) MRP ( 22) NADPH-oxidase ( 34) NOD ( 23) NOS ( 112) Nrf2 ( 46) PD-1/PD-L1 ( 13) PGE Synthase ( 5) Prostaglandin Receptor ( 113) ROS ( 136) TLR ( 57) Complement System ( 10) MyD88 ( 1) STING ( 14) NO Synthase ( 25) Thrombopoietin Receptor ( 3) NOD-like Receptor (NLR) ( 1) IRAK ( 7) Interleukin Related ( 0) Interleukin Related ( 5) Immunology & Inflammation... ( 0) FLAP ( 3) Cytokine release ( 0) Aryl Hydrocarbon Receptor ( 5) Reactive Oxygen Species ( 4) IFNAR ( 2)

EGFR ( 202) HER ( 33) JAK ( 116) Pim ( 24) STAT ( 95)

ERK ( 248) JNK ( 104) MAPK ( 90) MEK ( 54) MLK ( 9) MNK ( 6) p38 MAPK ( 123) Raf ( 78) Ras ( 49) S6 Kinase ( 31) TOPK ( 5)

ABC ( 14) ATPase ( 88) Calcium Channel ( 193) CFTR ( 16) CGRP Receptor ( 7) Chloride channel ( 25) CRM1 ( 8) GABA Receptor ( 161) Monoamine Transporter ( 9) Monocarboxylate transport... ( 8) Na-K-Cl cotransporter ( 3) NPC1L1 ( 7) OAT ( 5) OCT ( 6) P-gp ( 44) Potassium Channel ( 169) Proton pump ( 21) Sodium Channel ( 128) TRP/TRPV Channel ( 95) Anion Exchanger ( 1) VDAC ( 3) P2X Receptor ( 1) Na+/Ca2+ Exchanger ( 2) iGluR ( 11) HCN Channel ( 1) BCRP ( 4) Aquaporin ( 2)

Acetyl-CoA Carboxylase ( 10) AhR ( 21) Amino Acids and Derivativ... ( 24) Aminopeptidase ( 8) ATP Citrate Lyase ( 6) Calcium Channel ( 193) Carbonic Anhydrase ( 33) Carboxypeptidase(CPG2) ( 3) Casein Kinase ( 37) CETP ( 11) Decarboxylase ( 6) Dehydrogenase ( 127) DHFR ( 18) FAAH ( 21) Factor Xa ( 16) Fatty Acid Synthase ( 28) FXR ( 24) Glucokinase ( 91) GR ( 8) GSNOR ( 1) HIF/HIF Prolyl-Hydroxylas... ( 11) HMG-CoA Reductase ( 23) HSP ( 69) Hydrogenase ( 1) Hydroxylase ( 18) IDO ( 29) LDL ( 22) Lipase ( 16) Lipid ( 10) Lipoxygenase ( 50) Liver X Receptor ( 18) MAO ( 67) MPO ( 7) NADPH ( 20) NAMPT ( 10) P450 ( 157) PAI-1 ( 6) PDE ( 149) PED ( 2) Phosphatase ( 70) Phospholipase ( 46) Phosphorylase ( 8) PKM ( 85) PPAR ( 140) Procollagen C Proteinase ( 1) RAR/RXR ( 2) Reductase ( 29) Retinoid Receptor ( 31) ROR ( 21) Serine/threonin kinase ( 20) SGK ( 8) Thioredoxin ( 1) Transferase ( 37) transporter ( 30) UGT ( 11) Vitamin ( 55) CPT ( 1) FABP ( 4) hCE ( 0) N-Acetylglucosaminyltrans... ( 1) Transaminase ( 2) Endogenous Metabolite ( 345) Xanthine Oxidase ( 8) Mitochondrial Metabolism ( 17) hCE(human carboxylesteras... ( 0) glycosidase ( 0) aconitase ( 1) Epoxide Hydrolase ( 1) Acyltransferase ( 8) Neprilysin ( 5) Electron transport ( 2) stilbene oxidase ( 2) Stearoyl-CoA Desaturase (... ( 1) Reactive Oxygen Species ( 4) NEDD8 ( 1) MAGL ( 2) Isocitrate Dehydrogenase ... ( 2) Indoleamine 2,3-Dioxygena... ( 2) Hexokinase ( 5) Glutathione Peroxidase ( 5) Adenosine deaminase ( 1)

Antibacterial ( 350) Antibiotic ( 199) Antifection ( 471) Antifungal ( 107) CCR ( 48) GluCls ( 3) HBV ( 44) HCV Protease ( 83) HIV Protease ( 171) HSV ( 40) Influenza Virus ( 52) Integrase ( 5) Reverse Transcriptase ( 20) ribosome ( 35) Parasite ( 70) Anti-infection ( 18) RSV ( 6) SARS-CoV ( 13) Virus Protease ( 3) Bacterial ( 1)

5-HT Receptor ( 385) AChR ( 386) Adrenergic Receptor ( 251) BACE ( 30) Beta Amyloid ( 56) CaMK ( 28) COX ( 307) Dopamine Receptor ( 229) FAAH ( 21) GABA Receptor ( 161) Gamma-secretase ( 28) GluR ( 114) GlyT ( 8) Histamine Receptor ( 154) MAO ( 67) Neurokinin receptor ( 35) NMDAR ( 64) Norepinephrine ( 36) Opioid Receptor ( 101) OX Receptor ( 20) P2 Receptor ( 47) P-gp ( 44) Beta-Secretase ( 2) MT Receptor ( 7) Melanocortin Receptor ( 18) Neuropeptide Y Receptor ( 17) AChE ( 6) Serotonin Transporter ( 10) NMU2R ( 1) Monoamine Oxidase ( 3) iGluR ( 11) Adenylyl cyclase ( 2)

IκB/IKK ( 66) NF-κB ( 286) NOD ( 23) RIP kinase ( 5) IRAK ( 7) Reactive Oxygen Species ( 4)

Antioxidant ( 120) CAT ( 9) Free radical scavengers ( 7) Glutathione reductase ( 3) GPX ( 4) GST ( 6)

Akt ( 140) AMPK ( 72) ATM/ATR ( 61) DNA-PK ( 37) GSK-3 ( 72) MELK ( 6) mTOR ( 104) PDK ( 17) PI3K ( 226) PTEN ( 5) S6 Kinase ( 31) SIK ( 4) PI4K ( 5)

Acetyl-CoA Carboxylase ( 10) ATP Citrate Lyase ( 6) Caspase ( 147) Cysteine Protease ( 42) DPP-4 ( 24) Gamma-secretase ( 28) Glutaminase ( 3) HCV Protease ( 83) HIV Protease ( 171) MMP ( 90) Proteasome ( 41) Serine Protease ( 32) Thrombin ( 34) Tyrosinase ( 80) Acyltransferase ( 8)

Casein Kinase ( 37) Gamma-secretase ( 28) GSK-3 ( 72) Hedgehog/Smoothened ( 24) Hippo pathway ( 4) JAK ( 116) Porcupine ( 5) ROCK ( 41) STAT ( 95) TGF-beta/Smad ( 35) Wnt/beta-catenin ( 75) YAP ( 1) TACC ( 2) Stemness kinase ( 1) Smo ( 5)

ACK ( 4) ALK ( 62) Bcr-Abl ( 68) BTK ( 48) c-Fms ( 20) c-Kit ( 70) c-Met/HGFR ( 72) c-RET ( 33) CSF-1R ( 13) DYRK ( 38) EGFR ( 202) Ephrin Receptor ( 10) FAK ( 28) FGFR ( 76) FLT ( 97) Hck ( 3) HER ( 33) IGF-1R ( 31) PDGFR ( 85) PKA ( 52) PYK2 ( 5) Src ( 95) Syk ( 27) TAM Receptor ( 36) Tie-2 ( 7) Trk receptor ( 35) Tyrosine Kinases ( 46) VEGFR ( 166) Discoidin Domain Receptor... ( 7)

DUB ( 36) E2 conjugating ( 0) p97 ( 7) Proteasome ( 41) E1/E2/E3 Enzyme ( 18)

ACAT ( 8) advanced glycation end pr... ( 4) Decarboxylase ( 6) DprE1 ( 4) Others ( 15154) Platelet aggregation ( 7) Wnk ( 2) BVDV ( 0) Keap1-Nrf ( 1) NKCC ( 1) Salt-Inducible Kinase ( 0) PTP1B ( 0) Progesterone Receptor ( 1) Thyroid Hormone Receptor ( 1) Fer/FerT kinase ( 0) CYP19A1 ( 0) Cathepsin B ( 0) PGK ( 2) Streptokinase ( 34) Hepatitis C virus NS3 pro... ( 1) Vaccinia virus ( 1) High-affinity choline tra... ( 1) Genome polyprotein ( 1) Epstein-Barr nuclear anti... ( 1) Vesicular stomatitis viru... ( 1) Ataxin ( 174) 3C-like protease ( 1) Autoinducer 1 sensor kina... ( 1) Human immunodeficiency vi... ( 5) Human herpesvirus 1 strai... ( 1) Voltage-gated potassium c... ( 1) Malme-3M ( 1) Serotonin 2a (5-HT2a) rec... ( 1) Saccharomyces cerevisiae ( 2) Enoyl-acyl carrier reduct... ( 2) Putative uncharacterized ... ( 1) Egl nine homolog 3 ( 1) Paracentrotus lividus ( 1) SNB-75 ( 1) Candida albicans ( 1) NIH3T3 ( 1) Muscarinic acetylcholine ... ( 1) Cytochrome P450 2D6 ( 1) Ubiquitin-conjugating enz... ( 1) Staphylococcus aureus ( 3) Giardia ( 2) Putative fructose-1,6-bis... ( 2) Trypanosoma brucei rhodes... ( 1) Cannabinoid CB2 receptor ( 1) Trypanosoma brucei brucei ( 6) Toxoplasma gondii RH ( 1) Glycine transporter 2 ( 1) Relaxin receptor 1 ( 1) Phosphoglycerate kinase, ... ( 8) Nucleic Acid ( 2) ORF 73 ( 1) Large T antigen ( 4) Human parainfluenza virus... ( 1) Phosphotyrosine-protein p... ( 1) Enoyl-[acyl-carrier-prote... ( 1) Streptokinase A ( 21) Mycobacterium bovis BCG ( 4) Shiga toxin ( 2) HL-60 ( 1) INS1 ( 1) Smoothened homolog ( 1) Casein kinase I delta ( 0) Isoprenylcysteine carboxy... ( 1) Phosphodiesterase 6D ( 1) Excitatory amino acid tra... ( 1) Heat shock factor protein... ( 1) Sentrin-specific protease... ( 1) Phosphodiesterase 10A ( 1) Tyrosine-protein kinase S... ( 0) Formyl peptide receptor 1 ( 2) Transient receptor potent... ( 2) Macrophage migration inhi... ( 1) Intestinal alkaline phosp... ( 2) Cytochrome P450 17A1 ( 1) Butyrylcholinesterase ( 2) Zinc finger protein GLI1 ( 1) Heparanase ( 1) 1-acylglycerol-3-phosphat... ( 1) Voltage-gated T-type calc... ( 2) DNA dC->dU-editing enzyme... ( 2) Kappa opioid receptor ( 1) Fructose-bisphosphate ald... ( 1) Cytochrome P450 3A4 ( 2) Estrogen receptor alpha ( 2) Voltage-gated T-type calc... ( 3) C-C chemokine receptor ty... ( 2) A498 ( 1) MRC5 ( 2) Trace amine-associated re... ( 4) MDA-MB-468 ( 1) MCF7 ( 1) Prostaglandin E synthase ( 2) Fatty acid transport prot... ( 1) Flap endonuclease 1 ( 2) Matrix metalloproteinase-... ( 1) Nociceptin receptor ( 1) Long-chain fatty acid tra... ( 1) Glycogen synthase kinase-... ( 0) SF-539 ( 1) Peripheral-type benzodiaz... ( 1) HeLa ( 2) SK-BR-3 ( 1) Thioredoxin reductase 1, ... ( 5) Mus musculus ( 2) Tumour suppressor p53/onc... ( 1) Neutrophils ( 2) Breast cancer type 1 susc... ( 6) Alpha-synuclein ( 5) SNB-19 ( 1) No relevant target ( 2) HepG2 ( 4) RAW264.7 ( 2) Menin/Histone-lysine N-me... ( 15) UO-31 ( 1) DNA polymerase eta ( 6) Paired box protein Pax-8 ( 2) DNA dC->dU-editing enzyme... ( 18) Mitogen-activated protein... ( 1) A549 ( 1) DNA polymerase iota ( 36) Cavia porcellus ( 3) Tankyrase-2 ( 2) Plasmodium falciparum ( 419) Protein-glutamine gamma-g... ( 1) Cytochrome P450 19A1 ( 2) MOLT-4 ( 1) Leukocyte elastase ( 1) Xanthine dehydrogenase ( 1) RXF 393 ( 2) SK-MEL-2 ( 1) Cytochrome P450 2C9 ( 2) ATP-dependent molecular c... ( 5) Phosphodiesterase 5A ( 2) T98G ( 4) PI3-kinase p110-alpha sub... ( 0) Isocitrate dehydrogenase ... ( 5) Cyclooxygenase-2 ( 2) MIF/CD74 (Macrophage migr... ( 1) Runt-related transcriptio... ( 5) GABA-A receptor; anion ch... ( 0) Cytochrome P450 2C19 ( 2) NCI-H460 ( 1) OVCAR-5 ( 1) Vascular endothelial grow... ( 0) Aorta ( 2) Ubiquitin carboxyl-termin... ( 1) Vero ( 1) Prostanoid EP2 receptor ( 1) Peptidyl-prolyl cis-trans... ( 1) TAR DNA-binding protein 4... ( 202) Cytochrome P450 1A2 ( 5) Mothers against decapenta... ( 435) Fibroblast growth factor ... ( 1) microRNA 21 ( 105) Luciferin 4-monooxygenase ( 35) FAD-linked sulfhydryl oxi... ( 9) Signal transducer and act... ( 1) XF498 ( 2) PI3-kinase p110-delta sub... ( 0) HEK293 ( 557) Histone-lysine N-methyltr... ( 4) Monoamine oxidase B ( 5) Estradiol 17-beta-dehydro... ( 1) Tyrosine-protein kinase A... ( 0) Estrogen receptor beta ( 1) Aldo-keto-reductase famil... ( 2) Neurokinin 3 receptor ( 4) Cytochrome P450 11B2 ( 1) Sigma-1 receptor ( 2) Sigma opioid receptor ( 1) Endothelin-converting enz... ( 1) Testis-specific androgen-... ( 2) Anthrax lethal factor ( 9) Kinesin-like protein 1 ( 2) Peroxisome proliferator-a... ( 1) Tyrosyl-DNA phosphodieste... ( 3) Serotonin 2c (5-HT2c) rec... ( 4) Niemann-Pick C1 protein ( 17) Serotonin 6 (5-HT6) recep... ( 14) Ras-related protein Rab-9... ( 26) Adenosine A1 receptor ( 3) Adenosylmethionine-8-amin... ( 2) Inosine-5'-monophosphate ... ( 1) Bromodomain adjacent to z... ( 11) Lysine-specific demethyla... ( 0) G-protein coupled recepto... ( 1) Dopamine D2 receptor ( 3) Glutaminase kidney isofor... ( 5) Lipoxin A4 receptor ( 3) Arachidonate 15-lipoxygen... ( 2) Melanin-concentrating hor... ( 1) Aberrant vpr protein ( 23) Elongation of very long c... ( 1) Alkaline phosphatase, tis... ( 3) Beta-glucocerebrosidase ( 22) Alpha-galactosidase A ( 5) Nonstructural protein 1 ( 136) Vanilloid receptor ( 2) Metabotropic glutamate re... ( 8) 6-phospho-1-fructokinase ( 0) Neuropeptide S receptor ( 14) 4'-phosphopantetheinyl tr... ( 5) Tumor susceptibility gene... ( 3) Lysine-specific demethyla... ( 2) MAP kinase ERK2 ( 1) FK506 binding protein 12 ( 124) P-glycoprotein 1 ( 5) ATP-dependent DNA helicas... ( 9) Endoplasmic reticulum-ass... ( 7) Ecdysone receptor ( 1) Cholesteryl ester transfe... ( 2) Huntingtin ( 77) Lethal(3)malignant brain ... ( 10) 15-hydroxyprostaglandin d... ( 10) Short transient receptor ... ( 19) Transcriptional regulator... ( 5) Aldehyde dehydrogenase di... ( 1) ATP-dependent Clp proteas... ( 111) Thioredoxin glutathione r... ( 24) Cellular tumor antigen p5... ( 560) Cannabinoid CB1 receptor ( 8) ATP-binding cassette sub-... ( 1) Aldehyde dehydrogenase 1A... ( 58) TGF-beta receptor type II ( 2) Histone acetyltransferase... ( 25) Glucagon-like peptide 1 r... ( 213) Glycoprotein hormones alp... ( 110) Tyrosine-protein kinase r... ( 1) Survival motor neuron pro... ( 73) Histone-lysine N-methyltr... ( 68) Microtubule-associated pr... ( 613) Prelamin-A/C ( 542) Lysosomal alpha-glucosida... ( 42) Geminin ( 246) Arachidonate 15-lipoxygen... ( 5) Epoxide hydratase ( 3) Beta-2 adrenergic recepto... ( 6) Inositol monophosphatase ... ( 111) Thyroid hormone receptor ... ( 314) Thyroid stimulating hormo... ( 50) Dihydrofolate reductase ( 1) G protein-coupled recepto... ( 4) Beta-lactamase AmpC ( 613) Ataxin-2 ( 215) Hypoxia-inducible factor ... ( 4) Nuclear factor erythroid ... ( 389) Cruzipain ( 33) Guanine nucleotide-bindin... ( 164) Serine-protein kinase ATM ( 2) Pyruvate kinase isozymes ... ( 2) Nuclear receptor ROR-gamm... ( 140) ATPase family AAA domain-... ( 113) C-X-C chemokine receptor ... ( 3)