小分子抑制剂

ALK ( 65) Bcr-Abl ( 70) BTK ( 52) EGFR ( 209) FAK ( 31) FGFR ( 76) FLT ( 100) HER ( 36) HIF ( 46) JAK ( 120) PDGFR ( 88) Src ( 99) Syk ( 30) VDA ( 2) VEGFR ( 174)

Apoptosis inducer ( 6) ASK ( 8) BCL ( 141) Caspase ( 152) c-RET ( 34) Ferroptosis ( 14) FOXO1 ( 2) IAP ( 17) Mdm2 ( 37) p53 ( 63) PD-1/PD-L1 ( 15) PERK ( 13) Survivin ( 5) TNF ( 228) Fas/FasL ( 2) Apoptosis ( 199) RIP kinase ( 9) OXPHOS ( 4)

Autophagy ( 194) CXCR ( 51) LRRK2 ( 22) lysosomal autophagy ( 2) Mitophagy ( 7)

APC ( 6) Aurora Kinase ( 61) BMI-1 ( 6) CDK ( 248) cell cycle arrest ( 4) Chk ( 33) c-Myc ( 25) DHFR ( 20) DNA/RNA Synthesis ( 358) DYRK ( 41) Ferroptosis ( 14) KSP ( 4) LIM Kinase ( 9) Nucleoside Antimetabolite... ( 37) PD-1/PD-L1 ( 15) PLK ( 77) Rho ( 21) ROCK ( 41) Serine/threonin kinase ( 23) Wee1 ( 4) Haspin Kinase ( 3) Deubiquitinase ( 6) Antifolate ( 4) IRE1 ( 11)

Aurora Kinase ( 61) DNA Methyltransferase ( 26) Epigenetic Reader Domain ( 178) HDAC ( 122) HIF ( 46) HIF/HIF Prolyl-Hydroxylas... ( 14) Histone Demethylase ( 59) Histone Methyltransferase ( 239) JAK ( 120) PARP ( 90) Pim ( 25) PKC ( 114) Sirtuin ( 54) Histone Acetyltransferase ( 76) MicroRNA ( 4) Histone Acetylation ( 1) PAD ( 7)

Akt ( 146) Bcr-Abl ( 70) Dynamin ( 6) FAK ( 31) Gap Junction Protein ( 12) HSP ( 71) Integrin ( 52) Kinesin ( 26) Microtubule Associated ( 110) PAK ( 15) PKC ( 114) ROCK ( 41) Wnt/beta-catenin ( 84) Arp2/3 Complex ( 0) Myosin ( 4)

ATM/ATR ( 62) BMI-1 ( 6) DHFR ( 20) DNA ( 6) DNA Alkylation ( 35) DNA gyrase ( 14) DNA/RNA Synthesis ( 358) DNA-PK ( 37) HDAC ( 122) MTH1 ( 8) Nucleoside Antimetabolite... ( 37) PARP ( 90) PPAR ( 151) Sirtuin ( 54) Telomerase ( 15) Topoisomerase ( 115) DNA Alkylator/Crosslinker ( 3) Deubiquitinase ( 6)

Androgen Receptor ( 92) Aromatase ( 15) Estrogen/progestogen Rece... ( 128) Glucocorticoid Receptor ( 74) GPR ( 95) LHRH ( 2) Opioid Receptor ( 113) RAAS ( 98) Reductase ( 32) Thyroid hormone receptor(... ( 30) Estrogen Receptor/ERR ( 23) Oxytocin Receptor ( 6)

5-HT Receptor ( 405) Adenosine Receptor ( 49) Adiponectin receptor ( 3) Adrenergic Receptor ( 263) Annexin A ( 7) Bombesin Receptor ( 8) Bradykinin Receptor ( 17) cAMP ( 35) Cannabinoid Receptor ( 53) CaSR ( 9) cholecystokinin ( 15) CXCR ( 51) Dopamine Receptor ( 240) Endothelin Receptor ( 19) Glucagon Receptor ( 36) GNRH Receptor ( 22) GPCR19 ( 15) GPR ( 95) GRK ( 10) GTPase ( 12) Hedgehog/Smoothened ( 27) Histamine Receptor ( 166) LPA Receptor ( 13) Melatonin Receptor ( 2) Neurokinin receptor ( 44) Opioid Receptor ( 113) OX Receptor ( 22) PAFR ( 39) Prostaglandin Receptor ( 125) Protease-activated Recept... ( 31) Ras ( 56) S1P Receptor ( 38) SGLT ( 28) Sigma receptor ( 28) Somatostatin ( 9) Vasopressin Receptor ( 16) GHSR ( 16) Melanocortin Receptor ( 21) Neurotensin Receptor ( 11) Motilin Receptor ( 2) Melanin-concentrating Hor... ( 7) Neuropeptide Y Receptor ( 31) Leukotriene Receptor ( 3) EBI2/GPR183 ( 3) TSH Receptor ( 5) Oxytocin Receptor ( 6) Guanylate cyclase ( 8) CRFR ( 9) Apelin receptor ( 3)

AhR ( 22) Antiviral ( 59) Arginase ( 8) CCR ( 52) Cell wall ( 5) COX ( 318) CXCR ( 51) gp120/CD4 ( 8) Histamine Receptor ( 166) IL Receptor ( 188) Immunology & Inflammation... ( 97) LTR ( 28) MALT ( 6) MRP ( 23) NADPH-oxidase ( 35) NOD ( 25) NOS ( 115) Nrf2 ( 46) PD-1/PD-L1 ( 15) PGE Synthase ( 5) Prostaglandin Receptor ( 125) ROS ( 138) TLR ( 65) Complement System ( 16) MyD88 ( 2) STING ( 18) NO Synthase ( 33) Thrombopoietin Receptor ( 3) NOD-like Receptor (NLR) ( 1) IRAK ( 10) Interleukin Related ( 0) Interleukin Related ( 6) Immunology & Inflammation... ( 0) FLAP ( 3) Cytokine release ( 0) Aryl Hydrocarbon Receptor ( 6) Reactive Oxygen Species ( 16) IFNAR ( 3)

EGFR ( 209) HER ( 36) JAK ( 120) Pim ( 25) STAT ( 104)

ERK ( 251) JNK ( 106) MAPK ( 97) MEK ( 57) MLK ( 9) MNK ( 6) p38 MAPK ( 125) Raf ( 82) Ras ( 56) S6 Kinase ( 32) TOPK ( 5)

ABC ( 16) ATPase ( 88) Calcium Channel ( 206) CFTR ( 18) CGRP Receptor ( 9) Chloride channel ( 25) CRM1 ( 8) GABA Receptor ( 178) Monoamine Transporter ( 9) Monocarboxylate transport... ( 8) Na-K-Cl cotransporter ( 3) NPC1L1 ( 7) OAT ( 6) OCT ( 7) P-gp ( 47) Potassium Channel ( 179) Proton pump ( 24) Sodium Channel ( 136) TRP/TRPV Channel ( 108) Anion Exchanger ( 1) VDAC ( 3) P2X Receptor ( 2) Na+/Ca2+ Exchanger ( 2) iGluR ( 17) HCN Channel ( 1) BCRP ( 7) Aquaporin ( 4)

Acetyl-CoA Carboxylase ( 11) AhR ( 22) Amino Acids and Derivativ... ( 25) Aminopeptidase ( 9) ATP Citrate Lyase ( 7) Calcium Channel ( 206) Carbonic Anhydrase ( 35) Carboxypeptidase(CPG2) ( 3) Casein Kinase ( 40) CETP ( 12) Decarboxylase ( 6) Dehydrogenase ( 135) DHFR ( 20) FAAH ( 23) Factor Xa ( 16) Fatty Acid Synthase ( 30) FXR ( 25) Glucokinase ( 96) GR ( 8) GSNOR ( 1) HIF/HIF Prolyl-Hydroxylas... ( 14) HMG-CoA Reductase ( 24) HSP ( 71) Hydrogenase ( 1) Hydroxylase ( 22) IDO ( 28) LDL ( 22) Lipase ( 17) Lipid ( 14) Lipoxygenase ( 57) Liver X Receptor ( 19) MAO ( 71) MPO ( 7) NADPH ( 23) NAMPT ( 10) P450 ( 166) PAI-1 ( 8) PDE ( 161) PED ( 2) Phosphatase ( 76) Phospholipase ( 51) Phosphorylase ( 8) PKM ( 85) PPAR ( 151) Procollagen C Proteinase ( 1) RAR/RXR ( 3) Reductase ( 32) Retinoid Receptor ( 33) ROR ( 26) Serine/threonin kinase ( 23) SGK ( 10) Thioredoxin ( 1) Transferase ( 43) transporter ( 30) UGT ( 11) Vitamin ( 56) CPT ( 1) FABP ( 4) hCE ( 1) N-Acetylglucosaminyltrans... ( 1) Transaminase ( 2) Endogenous Metabolite ( 412) Xanthine Oxidase ( 10) Mitochondrial Metabolism ( 21) hCE(human carboxylesteras... ( 0) glycosidase ( 0) aconitase ( 1) Epoxide Hydrolase ( 4) Acyltransferase ( 12) Neprilysin ( 5) Electron transport ( 2) stilbene oxidase ( 2) Stearoyl-CoA Desaturase (... ( 3) Reactive Oxygen Species ( 16) NEDD8 ( 1) MAGL ( 2) Isocitrate Dehydrogenase ... ( 3) Indoleamine 2,3-Dioxygena... ( 3) Hexokinase ( 5) Glutathione Peroxidase ( 7) Adenosine deaminase ( 1)

Antibacterial ( 419) Antibiotic ( 215) Antifection ( 472) Antifungal ( 131) CCR ( 52) GluCls ( 3) HBV ( 46) HCV Protease ( 92) HIV Protease ( 187) HSV ( 41) Influenza Virus ( 60) Integrase ( 5) Reverse Transcriptase ( 21) ribosome ( 35) Parasite ( 94) Anti-infection ( 19) RSV ( 9) SARS-CoV ( 25) Virus Protease ( 7) Bacterial ( 2)

5-HT Receptor ( 405) AChR ( 409) Adrenergic Receptor ( 263) BACE ( 32) Beta Amyloid ( 61) CaMK ( 33) COX ( 318) Dopamine Receptor ( 240) FAAH ( 23) GABA Receptor ( 178) Gamma-secretase ( 29) GluR ( 125) GlyT ( 9) Histamine Receptor ( 166) MAO ( 71) Neurokinin receptor ( 44) NMDAR ( 71) Norepinephrine ( 38) Opioid Receptor ( 113) OX Receptor ( 22) P2 Receptor ( 51) P-gp ( 47) Beta-Secretase ( 4) MT Receptor ( 7) Melanocortin Receptor ( 21) Neuropeptide Y Receptor ( 31) AChE ( 12) Serotonin Transporter ( 13) NMU2R ( 1) Monoamine Oxidase ( 5) iGluR ( 17) Adenylyl cyclase ( 4)

IκB/IKK ( 67) NF-κB ( 292) NOD ( 25) RIP kinase ( 9) IRAK ( 10) Reactive Oxygen Species ( 16)

Antioxidant ( 132) CAT ( 9) Free radical scavengers ( 9) Glutathione reductase ( 3) GPX ( 5) GST ( 6)

Akt ( 146) AMPK ( 75) ATM/ATR ( 62) DNA-PK ( 37) GSK-3 ( 77) MELK ( 6) mTOR ( 111) PDK ( 19) PI3K ( 231) PTEN ( 6) S6 Kinase ( 32) SIK ( 4) PI4K ( 7)

Acetyl-CoA Carboxylase ( 11) ATP Citrate Lyase ( 7) Caspase ( 152) Cysteine Protease ( 48) DPP-4 ( 25) Gamma-secretase ( 29) Glutaminase ( 3) HCV Protease ( 92) HIV Protease ( 187) MMP ( 93) Proteasome ( 46) Serine Protease ( 32) Thrombin ( 34) Tyrosinase ( 81) Acyltransferase ( 12)

Casein Kinase ( 40) Gamma-secretase ( 29) GSK-3 ( 77) Hedgehog/Smoothened ( 27) Hippo pathway ( 4) JAK ( 120) Porcupine ( 5) ROCK ( 41) STAT ( 104) TGF-beta/Smad ( 38) Wnt/beta-catenin ( 84) YAP ( 3) TACC ( 2) Stemness kinase ( 1) Smo ( 7)

ACK ( 4) ALK ( 65) Bcr-Abl ( 70) BTK ( 52) c-Fms ( 21) c-Kit ( 74) c-Met/HGFR ( 74) c-RET ( 34) CSF-1R ( 14) DYRK ( 41) EGFR ( 209) Ephrin Receptor ( 12) FAK ( 31) FGFR ( 76) FLT ( 100) Hck ( 4) HER ( 36) IGF-1R ( 38) PDGFR ( 88) PKA ( 54) PYK2 ( 5) Src ( 99) Syk ( 30) TAM Receptor ( 38) Tie-2 ( 7) Trk receptor ( 35) Tyrosine Kinases ( 51) VEGFR ( 174) Discoidin Domain Receptor... ( 8)

DUB ( 36) E2 conjugating ( 0) p97 ( 7) Proteasome ( 46) E1/E2/E3 Enzyme ( 21)

ACAT ( 7) advanced glycation end pr... ( 4) Decarboxylase ( 6) DprE1 ( 4) Others ( 15353) Platelet aggregation ( 14) Wnk ( 2) BVDV ( 0) Keap1-Nrf ( 1) NKCC ( 1) Salt-Inducible Kinase ( 0) PTP1B ( 0) Progesterone Receptor ( 4) Thyroid Hormone Receptor ( 1) Fer/FerT kinase ( 0) CYP19A1 ( 0) Cathepsin B ( 0) PGK ( 2) Streptokinase ( 34) Hepatitis C virus NS3 pro... ( 1) Vaccinia virus ( 1) High-affinity choline tra... ( 1) Genome polyprotein ( 1) Epstein-Barr nuclear anti... ( 1) Vesicular stomatitis viru... ( 1) Ataxin ( 174) 3C-like protease ( 1) Autoinducer 1 sensor kina... ( 1) Human immunodeficiency vi... ( 5) Human herpesvirus 1 strai... ( 1) Voltage-gated potassium c... ( 1) Malme-3M ( 1) Serotonin 2a (5-HT2a) rec... ( 1) Saccharomyces cerevisiae ( 2) Enoyl-acyl carrier reduct... ( 2) Putative uncharacterized ... ( 1) Egl nine homolog 3 ( 1) Paracentrotus lividus ( 1) SNB-75 ( 1) Candida albicans ( 1) NIH3T3 ( 1) Muscarinic acetylcholine ... ( 1) Cytochrome P450 2D6 ( 1) Ubiquitin-conjugating enz... ( 1) Staphylococcus aureus ( 3) Giardia ( 2) Putative fructose-1,6-bis... ( 2) Trypanosoma brucei rhodes... ( 1) Cannabinoid CB2 receptor ( 1) Trypanosoma brucei brucei ( 6) Toxoplasma gondii RH ( 1) Glycine transporter 2 ( 1) Relaxin receptor 1 ( 1) Phosphoglycerate kinase, ... ( 8) Nucleic Acid ( 2) ORF 73 ( 1) Large T antigen ( 4) Human parainfluenza virus... ( 1) Phosphotyrosine-protein p... ( 1) Enoyl-[acyl-carrier-prote... ( 1) Streptokinase A ( 21) Mycobacterium bovis BCG ( 4) Shiga toxin ( 2) HL-60 ( 1) INS1 ( 1) Smoothened homolog ( 1) Casein kinase I delta ( 0) Isoprenylcysteine carboxy... ( 1) Phosphodiesterase 6D ( 1) Excitatory amino acid tra... ( 1) Heat shock factor protein... ( 1) Sentrin-specific protease... ( 1) Phosphodiesterase 10A ( 1) Tyrosine-protein kinase S... ( 0) Formyl peptide receptor 1 ( 3) Transient receptor potent... ( 2) Macrophage migration inhi... ( 1) Intestinal alkaline phosp... ( 2) Cytochrome P450 17A1 ( 1) Butyrylcholinesterase ( 2) Zinc finger protein GLI1 ( 1) Heparanase ( 1) 1-acylglycerol-3-phosphat... ( 1) Voltage-gated T-type calc... ( 2) DNA dC->dU-editing enzyme... ( 2) Kappa opioid receptor ( 1) Fructose-bisphosphate ald... ( 1) Cytochrome P450 3A4 ( 2) Estrogen receptor alpha ( 2) Voltage-gated T-type calc... ( 3) C-C chemokine receptor ty... ( 2) A498 ( 1) MRC5 ( 2) Trace amine-associated re... ( 4) MDA-MB-468 ( 1) MCF7 ( 1) Prostaglandin E synthase ( 2) Fatty acid transport prot... ( 1) Flap endonuclease 1 ( 2) Matrix metalloproteinase-... ( 1) Nociceptin receptor ( 1) Long-chain fatty acid tra... ( 1) Glycogen synthase kinase-... ( 0) SF-539 ( 1) Peripheral-type benzodiaz... ( 1) HeLa ( 2) SK-BR-3 ( 1) Thioredoxin reductase 1, ... ( 5) Mus musculus ( 2) Tumour suppressor p53/onc... ( 2) Neutrophils ( 2) Breast cancer type 1 susc... ( 6) Alpha-synuclein ( 5) SNB-19 ( 1) No relevant target ( 2) HepG2 ( 4) RAW264.7 ( 2) Menin/Histone-lysine N-me... ( 15) UO-31 ( 1) DNA polymerase eta ( 6) Paired box protein Pax-8 ( 2) DNA dC->dU-editing enzyme... ( 18) Mitogen-activated protein... ( 1) A549 ( 1) DNA polymerase iota ( 36) Cavia porcellus ( 3) Tankyrase-2 ( 2) Plasmodium falciparum ( 419) Protein-glutamine gamma-g... ( 1) Cytochrome P450 19A1 ( 2) MOLT-4 ( 1) Leukocyte elastase ( 1) Xanthine dehydrogenase ( 1) RXF 393 ( 2) SK-MEL-2 ( 1) Cytochrome P450 2C9 ( 2) ATP-dependent molecular c... ( 5) Phosphodiesterase 5A ( 2) T98G ( 4) PI3-kinase p110-alpha sub... ( 0) Isocitrate dehydrogenase ... ( 5) Cyclooxygenase-2 ( 2) MIF/CD74 (Macrophage migr... ( 1) Runt-related transcriptio... ( 5) GABA-A receptor; anion ch... ( 0) Cytochrome P450 2C19 ( 2) NCI-H460 ( 1) OVCAR-5 ( 1) Vascular endothelial grow... ( 0) Aorta ( 2) Ubiquitin carboxyl-termin... ( 1) Vero ( 1) Prostanoid EP2 receptor ( 1) Peptidyl-prolyl cis-trans... ( 1) TAR DNA-binding protein 4... ( 202) Cytochrome P450 1A2 ( 5) Mothers against decapenta... ( 435) Fibroblast growth factor ... ( 1) microRNA 21 ( 105) Luciferin 4-monooxygenase ( 35) FAD-linked sulfhydryl oxi... ( 9) Signal transducer and act... ( 1) XF498 ( 2) PI3-kinase p110-delta sub... ( 0) HEK293 ( 557) Histone-lysine N-methyltr... ( 4) Monoamine oxidase B ( 5) Estradiol 17-beta-dehydro... ( 1) Tyrosine-protein kinase A... ( 0) Estrogen receptor beta ( 1) Aldo-keto-reductase famil... ( 2) Neurokinin 3 receptor ( 4) Cytochrome P450 11B2 ( 1) Sigma-1 receptor ( 2) Sigma opioid receptor ( 1) Endothelin-converting enz... ( 1) Testis-specific androgen-... ( 2) Anthrax lethal factor ( 9) Kinesin-like protein 1 ( 2) Peroxisome proliferator-a... ( 1) Tyrosyl-DNA phosphodieste... ( 3) Serotonin 2c (5-HT2c) rec... ( 4) Niemann-Pick C1 protein ( 17) Serotonin 6 (5-HT6) recep... ( 14) Ras-related protein Rab-9... ( 26) Adenosine A1 receptor ( 3) Adenosylmethionine-8-amin... ( 2) Inosine-5'-monophosphate ... ( 1) Bromodomain adjacent to z... ( 11) Lysine-specific demethyla... ( 0) G-protein coupled recepto... ( 1) Dopamine D2 receptor ( 3) Glutaminase kidney isofor... ( 5) Lipoxin A4 receptor ( 3) Arachidonate 15-lipoxygen... ( 2) Melanin-concentrating hor... ( 1) Aberrant vpr protein ( 23) Elongation of very long c... ( 1) Alkaline phosphatase, tis... ( 3) Beta-glucocerebrosidase ( 22) Alpha-galactosidase A ( 5) Nonstructural protein 1 ( 136) Vanilloid receptor ( 2) Metabotropic glutamate re... ( 8) 6-phospho-1-fructokinase ( 0) Neuropeptide S receptor ( 14) 4'-phosphopantetheinyl tr... ( 5) Tumor susceptibility gene... ( 3) Lysine-specific demethyla... ( 2) MAP kinase ERK2 ( 1) FK506 binding protein 12 ( 124) P-glycoprotein 1 ( 5) ATP-dependent DNA helicas... ( 9) Endoplasmic reticulum-ass... ( 7) Ecdysone receptor ( 1) Cholesteryl ester transfe... ( 2) Huntingtin ( 77) Lethal(3)malignant brain ... ( 10) 15-hydroxyprostaglandin d... ( 10) Short transient receptor ... ( 19) Transcriptional regulator... ( 5) Aldehyde dehydrogenase di... ( 1) ATP-dependent Clp proteas... ( 111) Thioredoxin glutathione r... ( 24) Cellular tumor antigen p5... ( 560) Cannabinoid CB1 receptor ( 8) ATP-binding cassette sub-... ( 1) Aldehyde dehydrogenase 1A... ( 58) TGF-beta receptor type II ( 2) Histone acetyltransferase... ( 25) Glucagon-like peptide 1 r... ( 213) Glycoprotein hormones alp... ( 110) Tyrosine-protein kinase r... ( 2) Survival motor neuron pro... ( 73) Histone-lysine N-methyltr... ( 68) Microtubule-associated pr... ( 613) Prelamin-A/C ( 542) Lysosomal alpha-glucosida... ( 42) Geminin ( 246) Arachidonate 15-lipoxygen... ( 5) Epoxide hydratase ( 3) Beta-2 adrenergic recepto... ( 6) Inositol monophosphatase ... ( 111) Thyroid hormone receptor ... ( 314) Thyroid stimulating hormo... ( 50) Dihydrofolate reductase ( 1) G protein-coupled recepto... ( 4) Beta-lactamase AmpC ( 613) Ataxin-2 ( 215) Hypoxia-inducible factor ... ( 4) Nuclear factor erythroid ... ( 389) Cruzipain ( 33) Guanine nucleotide-bindin... ( 164) Serine-protein kinase ATM ( 2) Pyruvate kinase isozymes ... ( 2) Nuclear receptor ROR-gamm... ( 140) ATPase family AAA domain-... ( 113) C-X-C chemokine receptor ... ( 3)