CNS化合物库US
US CNS-permeable Compounds Library
很棒产品编号US2100
UORSY 中 CNS 渗透化合物库包含10651个化合物。CNS（中枢神经系统）靶向药物在其理化特性和结构特点上与非 CNS 靶向分子有所不同。前者的化合物必须更为刚性，并具有较低的 TPSA 和 logP 值，以便能够穿过血脑屏障（BBB）。通过采用文献数据、Ro3规则以及我们内部的参数，我们创建了一种满足 CNS 样特征的独特化合物库。当前的设置将为与CNS 活性分子相关的药物发现项目提供良好的起点。
产品编号US2100
CNS化合物库US规格
- 1 mg
- 100 μL x 10 mM (in DMSO)
- 250 μL x 10 mM (in DMSO)
Product Description
CNS-targeted drugs differ from the non-CNS-targeted molecules in their physicochemical profiles and structural properties. The former compounds have to be more rigid and to have lower TPSA and logP for being able to cross the Blood-brain barrier (BBB). Implementing the literature data,1 Ro3, and our in-house parameters, we created a library of unique compounds that meet CNS-like criteria. The current settings will be a good starting point for drug discovery projects related to CNS-active molecules.
包装和储存
- 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
- 干粉蓝冰运输，DMSO溶液干冰运输；
- 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
化合物库定制
