目录号 | 产品详情 | 靶点 | |
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T35813 | |||
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM) in a fatty acid oxidation assay of rat L6 muscle cells with desirable oral pharmacokinetic properties. In a transactivation assay using human PPAR receptors, CAY10592 acts as a selective partial PPARδ agonist (EC50 = 53 nM) with no effect on PPARα or PPARγ activity up to 30 μM. Chronic treatment of high fat fed ApoB100/CETP-transgenic mice with CAY10592 at a dose of 20 mg/kg increases HDL levels, decreases LDL and TG levels, and improves insulin sensitivity. | |||
T37295 | |||
Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones. | |||
T71303 | |||
Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear leukocytes (PMN) with IC50 values of 29 and 14 µM, respectively. Flufenamic acid also activates various ion channels, including transient receptor potential canonical 6 (TRPC6) and the large-conductance calcium-activated potassium channel (KCa1.1). It also inhibits various ion channels, including TRPC3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Flufenamic acid (20 mg/kg) reduces increases in intestinal fluid secretion and intestinal barrier disruption in mice ...... | |||
T73677 | |||
SR 142948 dihydrochloride是一种口服活性高、选择性强的非肽类神经降压素受体(NT)拮抗剂,其在h-NTR1-CHO细胞、HT-29细胞和成年大鼠脑中IC50分别为1.19 nM、0.32 nM、3.96 nM。在HT-29细胞中,该化合物能够有效拮抗NT诱导的肌醇单磷酸盐形成,IC50为3.9 nM。此外,SR 142948 dihydrochloride在体内能够阻断NT诱导的体温下降、镇痛和转向行为,且具有良好的血脑屏障通透性,适用于精神疾病研究。 | |||
T83777 | |||
LAU-0901是一种血小板活化因子(PAF)受体拮抗剂。在体内,LAU-0901(30、60及90 mg/kg)通过减少梗塞体积和改善大鼠由中脑动脉阻塞(MCAO)引起的脑缺血模型中的神经功能来发挥作用。它还能减少同一模型中的小胶质细胞浸润,并增加星形胶质细胞和神经元的存活率。单独使用LAU-0901(30 mg/kg)或与阿托伐他汀联合使用,能减少U87MG胶质母细胞瘤小鼠原位肿瘤模型中的肿瘤生长。 | |||
T83964 | |||
tri-GalNAc-PEG3-Azide是一种用于溶酶体靶向嵌合体(LYTAC)研究与开发的功能化无乙酰神经氨酸糖蛋白受体(ASGPR)配体;每个分子包括三个ASGPR配体、一个PEG3连接器和一个准备用于接合的活性叠氮基团。绑定到ASGPR后,tri-GalNAc结合物通过ASGPR介导的内吞作用高效地被内化。tri-GalNAc接合可作为一种策略,以细胞特异性方式有效地将如RNA或Cas9复合体等货物递送至肝细胞。可用于生成LYTACs,或用染料标记以进行组织成像。 | |||
TP1989L | |||
Nogo-66 (1-40) aceate (475221-20-6 Free base) 是对应于 Nogo-66 残基 1 - 40 的肽片段,Nogo-66 是抑制轴突生长的髓磷脂蛋白 Nogo 的结构域。Nogo-66 (1-40) aceate 作为 Nogo-66 受体 (NgR) 的竞争性拮抗剂,阻断 Nogo-66 和 CNS 髓磷脂诱导的轴突生长抑制,但不会减少髓磷脂相关糖蛋白 (MAG) 体外抑制神经突生长。Nogo-66 (1-40) aceate 促进体内脊髓损伤后半切脊髓轴突的再生和运动恢复。 | |||
TP2049L | |||
CRSP-1 acetate(697327-12-1 Free base) 是一种内源性中枢降钙素(CT)受体激动剂,其刺激cAMP形成的效力是CT的350倍(ED50值分别为0.2和71nM)。CRSP-1 acetate 对降钙素基因相关肽 (CGRP) 和肾上腺髓质素受体没有活性。CRSP-1 acetate 抑制多核破骨细胞的形成,其体外功效与CT相似。CRSP-1 acetate 抑制自由进食大鼠的食物摄入并升高体温,并显着降低体内血浆钙水平。 | |||
T22393 | 5-HT Receptor | ||
Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). | |||
T37763 | |||
Selective TRPC5 activator (EC50 = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50 = 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers. Beckmann et al (2017) A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 66 10 PMID:28807145 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03739 | Transferrin Receptor/TFRC Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.5 kDa and the accession number is XP_005545315.1&NP_001244232.1.
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TMPY-01053 | Prolactin Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Prolactin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P16471-1.
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TMPY-01146 | Insulin Receptor Protein, Human, Recombinant (long isoform, His) | Human | HEK293 Cells | ||
Insulin Receptor Protein, Human, Recombinant (long isoform, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 107 kDa and the accession number is P06213-1.
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TMPY-01725 | Leptin Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Leptin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is P48357-1.
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TMPY-01873 | Transferrin Receptor/TFRC Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is AAA61153.1.
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TMPY-05096 | Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 103.6 kDa and the accession number is CAA25527.1.
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TMPY-02294 | Transferrin Receptor/TFRC Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.3 kDa and the accession number is Q62351.
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TMPY-06661 | Transferrin Receptor/TFRC Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.59 kDa and the accession number is Q99376.
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TMPY-02434 | Prolactin Receptor Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Prolactin Receptor Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P05710-1.
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TMPY-04395 | Insulin Receptor Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Insulin Receptor Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.3 kDa and the accession number is P06213-1.
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TMPK-01200 | Nogo Receptor/RTN4R Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes.
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TMPY-01612 | CD155/PVR Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
CD155/PVR Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.8 kDa and the accession number is Q0MSE6.
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TMPY-01149 | Insulin Receptor Protein, Human, Recombinant (short isoform, His) | Human | HEK293 Cells | ||
Insulin Receptor Protein, Human, Recombinant (short isoform, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 106 kDa and the accession number is P06213-2.
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TMPY-03144 | Nogo Receptor/RTN4R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Nogo Receptor/RTN4R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9BZR6.
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TMPY-02984 | Prolactin Receptor Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Prolactin Receptor Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P07321.
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TMPH-00932 | Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli | ||
Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
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TMPY-05025 | Thrombin Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Thrombin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is A0A024RAP7.
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TMPY-05283 | Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated | Human | HEK293 Cells | ||
Insulin Receptor Protein, Human, Recombinant (long isoform, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 107 kDa and the accession number is P06213-1.
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TMPY-00874 | Leptin Receptor Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
Leptin Receptor Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 121.4 kDa and the accession number is P48357-1.
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TMPY-01566 | Prolactin Receptor Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
Prolactin Receptor Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.5 kDa and the accession number is Q08501-1.
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TMPY-02987 | Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells | ||
Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.28 kDa and the accession number is P48281.
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TMPY-01056 | Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 73 kDa and the accession number is Q9BZR6.
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TMPY-02706 | Vitamin D Receptor/VDR Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Vitamin D Receptor/VDR Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P11473.
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TMPY-01163 | Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is Q99PI8.
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TMPY-05274 | IL-23R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-23R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.3 kDa and the accession number is AAM44229.1.
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TMPY-04717 | CD122/IL2RB Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
CD122/IL2RB Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.1 kDa and the accession number is H9Z8K1.
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TMPY-02934 | IL-2RG Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IL-2RG Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.5 kDa and the accession number is Q68FU6.
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TMPY-05102 | CD122/IL2RB Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CD122/IL2RB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is P26896.
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TMPJ-00154 | IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells) | Mouse | HEK293 Cells | ||
Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.
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TMPY-04649 | ROR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is Q01973.
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TMPJ-00994 | LTBR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
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TMPY-01221 | Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 73.8 kDa and the accession number is Q99PI8.
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TMPY-00085 | Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) | Human | HEK293 Cells | ||
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.1 kDa and the accession number is P30988-2.
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TMPY-03860 | Endothelin B Receptor Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Endothelin B Receptor Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34.4 kDa and the accession number is P24530-1.
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TMPY-00181 | Endothelin B Receptor Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Endothelin B Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 9.5 kDa and the accession number is P24530-1.
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TMPY-03951 | IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is F7H8F9.
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TMPY-06022 | FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A2K5UR19&NP_001181576.1.
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TMPY-01883 | EPOR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
EPOR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1.
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TMPY-05617 | Transferrin Receptor/TFRC Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
Transferrin Receptor/TFRC Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is P02786.
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TMPY-00418 | IL-21R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-21R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is AAL82636.1.
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TMPY-04818 | EGFR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
EGFR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is A0A2K5WK39.
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TMPY-00317 | Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) | Human | HEK293 Cells | ||
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.9 kDa and the accession number is P30988-1.
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TMPY-02335 | OSMR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
OSMR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 83.7 kDa and the accession number is O70458-1.
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TMPY-02824 | IL-18R alpha Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
IL-18R alpha Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5kDa and the accession number is A0A8I6A1C2.
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TMPY-05090 | CD25/IL2R alpha Protein, Rat, Recombinant (His) | Rat | Baculovirus Insect Cells | ||
CD25/IL2R alpha Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 25.9 kDa and the accession number is A6JLS0.
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TMPY-03776 | CD25/IL2R alpha Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.4 kDa and the accession number is H6WS54.
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TMPY-03644 | CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.1 kDa and the accession number is H6WS54.
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TMPJ-00335 | TGFBR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
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TMPY-05644 | CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated | Rhesus | HEK293 Cells | ||
CD25/IL2R alpha Protein, Rhesus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24.9 kDa and the accession number is Q5MNY4.
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TMPY-05394 | ROR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.8 kDa and the accession number is Q01974.
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