目录号 | 产品详情 | 靶点 | |
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T77037 | |||
Insulinefsitora alfa (LY-3209590) 为选择性胰岛素受体(IR)激动剂,该融合蛋白融合了人胰岛素受体(IR)激动剂与人免疫球蛋白G2(IgG2)的片段可结晶(Fc)结构域,分子量为64.1 kDa。Insulinefsitora alfa展现出良好的耐受性,并在糖尿病治疗中显示出潜在应用价值。 | |||
T78716 | Others | ||
MKA031(compound 6y)作为一种非竞争性MIF抑制剂,展现出1.7 μM的IC50。该化合物能够阻断MIF/AIF相互作用、抑制MIF核内转移,并干预MNNG所诱发的细胞死亡。MKA031主要用于研究慢性丙型肝炎病毒感染。 | |||
T87526 | |||
TI17 是一种抑制 Trip13 的甲状腺激素受体相互作用蛋白的化合物,具有抗癌活性。TI17 能显著抑制多发性骨髓瘤 (MM) 细胞的增殖,并诱导细胞周期停滞和细胞凋亡 (apoptosis)。Trip13 是一种 AAA-ATP 酶,参与介导双链断裂 (DSB) 修复;TI17 通过抑制 Trip13 的功能,增加 DNA 损伤。 | |||
T76229 | |||
p3Ysh-3 是 STEP Phosphatase-GluA2 AMPA 受体相互作用的肽抑制剂,Ki 为 1.09 μM。p3Ysh-3 在东莨菪碱处理的大鼠模型中恢复记忆缺陷并表现出抗焦虑和抗抑郁作用。p3Ysh-3 是一种很有前途的先导化合物,可用于新型认知增强剂和/或行为调节剂。 | |||
T37496 | |||
Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods. | |||
T82295 | |||
GluR23Y是一种具有生物活性的肽,应用于ELISA细胞表面测定,专用于监测培养的海马神经元内AMPA受体在胰岛素刺激下的内吞情况。该肽能够阻止由胰岛素引起的AMPA受体数量的下降。通过将GluR23Y与HIV-1的膜转导结构域融合,实现对神经元的传递,从而有效抑制了胰岛素诱导的效应。 | |||
T29011 | Thyroid hormone receptor(THR) Endogenous Metabolite | ||
Triiodothyronine sulfate 是一种甲状腺激素三碘甲状腺原氨酸的主要代谢物,是一种甲状腺激素,与 β1 甲状腺激素受体结合并激活其特性。 | |||
T88108 | |||
TLR8 agonist7 作为 Toll 样受体 8 (TLR8) 的激动剂,具有 EC50 值低于 250 nM。该化合物在人和鼠血浆中展现出良好的稳定性,并能有效诱导细胞因子 TNFα 的分泌,其 EC50 值低于 1 μM。此外,在 MC38-HER2 异种移植小鼠模型中,TLR8 agonist7 显示了显著的抗肿瘤活性,肿瘤生长抑制 (TGI) 率高达 98%。 | |||
T78279 | |||
Cixutumumab(IMC-A12)是一种高亲和力人源化抗IGF-1R单克隆抗体,能抑制配体依赖型受体活化及下游信号传导,并介导IGF-1R的内化与降解。该抗体显示出对多种癌症如肺癌、恶性肿瘤、白血病、非小细胞肺癌和前列腺癌的广泛抗肿瘤活性。 | |||
T75015 | Others | ||
HX103 是一种基于表皮生长因子受体 (EGFR)-酪氨酸激酶抑制剂 (TKI) 的荧光探针。HX103 抑制 EGFR19 del、EGFRL858R、EGFRwild type 和 EGFRT790M,IC50分别为1.3、1.5、4.0 和 977 nM。HX103 可用于定量活性 EGFR,可用于 NSCLC 的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02286 | Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Matrix protein 1/M1 Protein (His) | H1N1 | E. coli | ||
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Matrix protein 1/M1 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 29.3 kDa and the accession number is B4UPA8.
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TMPY-02824 | IL-18R alpha Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
IL-18R alpha Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5kDa and the accession number is A0A8I6A1C2.
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TMPY-06022 | FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
FOLR1 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is A0A2K5UR19&NP_001181576.1.
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TMPY-03951 | IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
IL-18R alpha Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is F7H8F9.
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TMPY-04986 | ROR1 Protein, Human, Recombinant, Biotinylated | Human | HEK293 Cells | ||
ROR1 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 42.8 kDa and the accession number is Q01973.
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TMPY-04649 | ROR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is Q01973.
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TMPY-05840 | IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
IL-1RAP/IL-1RAcP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.56 kDa and the accession number is P59822-1.
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TMPY-00437 | IL-11R alpha chain 1/IL-11RA1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IL-11R alpha chain 1/IL-11RA1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.1 kDa and the accession number is A6IIX5.
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TMPY-02702 | ASGR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ASGR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.8 kDa and the accession number is P07306.
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TMPY-01803 | FOLR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FOLR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is P35846.
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TMPY-05542 | ASGR1 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
ASGR1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.8 kDa and the accession number is P07306.
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TMPY-01376 | IL-18R alpha Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-18R alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.8 kDa and the accession number is Q61098.
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TMPY-05782 | IL-18R alpha Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 Cells | ||
IL-18R alpha Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.74 kDa and the accession number is Q61098.
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TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinase domain. VEGFR-1is an essential receptor tyrosine kinase and plays an important role in theregulation of VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. It is also mediators of neurotrophic activity and regulators of hematopoietic development. VEGFR-1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF.It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells and promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. VEGFR-1 can also promote PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
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TMPY-01258 | IL-13RA1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-13RA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1.
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TMPY-05511 | NKp46/NCR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
NKp46/NCR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is A0A0R4IZY7.
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TMPH-02739 | IRAK3 Protein, Mouse, Recombinant (E. coli, His & Myc) | Mouse | E. coli | ||
IRAK3 Protein, Mouse, Recombinant (E. coli, His & Myc) is expressed in E. coli.
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TMPY-01151 | IFNGR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IFNGR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is A0A0S2Z3Y2.
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TMPY-04125 | PTP1B Protein, Human, Recombinant (His) | Human | E. coli | ||
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation.
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TMPY-03079 | IL-1R2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-1R2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.6 kDa and the accession number is P27931.
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TMPY-01774 | TREM-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TREM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is Q38L15.
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TMPY-02953 | TEM8/ANTXR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key proteins. ANTXR1 interacts with extracellular matrix proteins and with the actin cytoskeleton. It functions in cell attachment and migration. ANTXR1 also mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
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TMPY-01302 | CD200R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD200R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is B7ZKV2.
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TMPJ-00147 | FOLR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
FOLR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-75 kDa and the accession number is P15328.
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TMPY-05593 | IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 42.4 kDa and the accession number is Q9NPH3-1.
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TMPY-01815 | FOLR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
FOLR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is A0A024R5H1.
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TMPY-01085 | VLDLR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is abundant in heart, skeletal muscle, also ovary and kidney, but not in liver. VLDLR binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. VLDLR mediates the phosphorylation of mDab1 (mammalian disabled protein) via binding to Reelin, and induces the modulation of Tau phosphorylation. This pathway regulates the migration of neurons along with the radial glial fiber network during brain development. Defects of VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH), a syndrome characterized by moderate-to-profound mental retardation, delayed ambulation, and predominantly truncal ataxia.
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TMPY-01701 | IL-12RB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-12RB1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.5 kDa and the accession number is P42701-1.
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TMPY-02355 | IFNGR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IFNGR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P15261.
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TMPY-01170 | IL-13RA1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-13RA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is O09030.
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TMPY-02647 | IFNAR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IFNAR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.6 kDa and the accession number is P17181-1.
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TMPY-03686 | NKG2A/CD159a Protein, Cynomolgus/Rhesus, Recombinant (hFc) | Cynomolgus,Rhesus | HEK293 Cells | ||
NKG2A/CD159a Protein, Cynomolgus/Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 30.8 kDa and the accession number is Q68VD2.
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TMPY-01219 | IL-18R alpha Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-18R alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q13478.
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TMPY-01081 | SR-BI/SCARB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SR-BI/SCARB1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is A0A024RBS4.
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TMPY-05394 | ROR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.8 kDa and the accession number is Q01974.
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TMPY-05491 | IL-18R alpha Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
IL-18R alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.5 kDa and the accession number is Q13478.
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TMPY-04096 | ST2/IL-1 RL1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P14719-1.
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TMPY-00850 | ST2/IL-1 RL1 Protein, Human, Recombinant | Human | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2.
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TMPY-00849 | ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2.
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TMPY-02028 | RON/CD136 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. This assessment of gene expression indicates the importance of genetic factors in contributing to lung injury and points to strategies for intervention in the progression of inflammatory diseases. It had been shown that MST1R/CD136 plays a critical role in Ni-induced lung injury in mice. The overexpression of MSP, MT-SP1, and MST1R was a strong independent indicator of both metastasis and death in human breast cancer patients and significantly increased the accuracy of an existing gene expression signature for poor prognosis. Stimulation of MST1R leads to its transphosphorylation and the ultimate activation of numerous intracellular signaling pathways, such as the classical mitogen-activated protein kinase pathway, the phosphatidylinositol (PI)3-kinase pathway, and the JNK pathway.
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TMPY-00856 | TCCR Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
TCCR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79 kDa and the accession number is Q6UWB1.
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TMPY-01359 | ST2/IL-1 RL1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2.
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TMPY-01305 | OSMR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
OSMR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.6 kDa and the accession number is Q99650-1.
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TMPY-02575 | PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH).The functional single nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) gene were predicted to be correlated with the susceptibility of colorectal cancer (CRC).
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TMPY-00834 | IGF1R/CD221 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IGF1R/CD221 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81 kDa and the accession number is P08069.
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TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VEGFR2/KDR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession number is P35968-1.
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TMPY-01084 | TrkA Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TrkA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is P04629-1.
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TMPY-04853 | TSHR Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis.
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TMPY-04580 | IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.7 kDa and the accession number is Q3UEL3.
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TMPY-04483 | IRAK4 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. It also phosphorylates IRAK1. A member of the IL-1 receptor (IL-1R)-associated kinase (IRAK) family, IRAK4, has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. IL-1-mediated IRAK4 kinase activity in T cells is essential for the induction of IL-23R expression, Th17 differentiation, and autoimmune disease. Pharmacological blocking of IRAK4 kinase activity will retain some levels of host defense while reducing the levels and duration of inflammatory responses, which should provide beneficial therapies for sepsis and chronic inflammatory diseases. Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) which is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. Defects in IRAK4 are also the cause of IRAK4 deficiency which causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
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