FOLR1 Protein, Human, Recombinant (hFc)

Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

规格	价格/CNY		数量
10 μg	￥ 430	现货
50 μg	￥ 1,320	5日内发货
500 μg	￥ 11,700	5日内发货
1 mg	￥ 17,600	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 430

现货

50 μg

￥ 1,320

5日内发货

500 μg

￥ 11,700

5日内发货

1 mg

￥ 17,600

5日内发货

生物活性

Loaded Human FOLR1-Fc on APS Biosensor, can bind Anti-Human FOLR1 mAb with an affinity constant of 0.11 nM as determined in BLI assay. (Regularly tested)

TargetMol Bioactive

产品描述

种属	Human
表达系统	Human Cells
标签	C-Fc
蛋白编号	P15328
别名	Folate receptor 1, Folate receptor, Folate receptor alpha, FOLR1, FR-alpha, Adult folate-binding protein, FR-α, Folate receptor α, Ovarian tumor-associated antigen MOv18, FBP
氨基酸序列	Arg25-Ser234
蛋白构建	Recombinant Human Folate receptor alpha is produced by our Mammalian expression system and the target gene encoding Arg25-Ser234 is expressed with a human IgG1 Fc tag at the C-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC.
分子量	55-75 kDa, reducing conditions

内毒素	Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

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复溶计算器

重组蛋白稀释计算器

比活力计算器

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

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FOLR1 Protein, Human, Recombinant (hFc)

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