目录号 | 产品详情 | 靶点 | |
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T62018 | Others | ||
Adenosine receptor inhibitor 2 (compound 14b) 是有效的AR(腺苷受体)抑制剂。Adenosine receptor inhibitor 2 显示对 A1/A2AARs 的双重亲和性,对 A1- 的亲和性比A2AAR 更高。Adenosine receptor inhibitor 2 抑制A1AR 和A2AAR 的Ki 分别为 52.2 和 167 nM。 | |||
T12163 | Adenosine Receptor | ||
N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine) 是一种腺苷衍生物和腺苷受体激动剂,对大鼠和人 A1 的 Ki 值分别为 11.8 nM 和 30.1 nM。 | |||
T37793 | Adenosine Receptor | ||
A2B receptor antagonist 2 是腺苷受体 A2B 的拮抗剂(rA1 的 Ki = 2.30 μM,rA2A 的 Ki = 6.8 μM,hA2B 的 3.44 μM)。 | |||
T5940 | PDE Adenosine Receptor | ||
Proxyphylline (7-(2-Hydroxypropyl)theophylline) 是甲基黄嘌呤衍生物,可用作心脏活化剂、血管扩张剂和支气管扩张剂。 | |||
T6884 | Adenosine Receptor | ||
Namodenoson (2-Cl-IB-MECA) 是一个选择性的 A3 腺苷受体 (A3AR) 激动剂,Ki 为 0.33 nM,选择性分别是 A1 和 A2 的 2500 和 1400 倍。 | |||
T9330 | Adenosine Receptor | ||
MIPS521 ({2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone) 是腺苷受体 (A1AR) 的正向变构调节剂,通过调节大鼠脊髓中内源性腺苷水平的升高,在体内表现出减轻疼痛的作用。 | |||
T23336 | Adenosine Receptor | ||
SCH442416 (SCH 442416) 是选择性和可透过血脑屏障的腺苷A2A 受体拮抗剂,对人和大鼠 A2AR 的Ki 值分别为 0.048 和 0.5 nM,可用于在大鼠和灵长类动物大脑中对腺苷 A2A 受体成像。 | |||
T7320 | Adenosine Receptor | ||
Tozadenant (SYN115) 是 A2A 腺苷受体拮抗剂,对人和恒河猴的 Ki 分别为 11.5 和 6 nM。 | |||
T9516 | Adenosine Receptor | ||
Binodenoson (WRC 0470) 是一种选择性A2A 腺苷受体激动剂,KD 为270 nM。它是一种短效冠状动脉血管扩张剂,作为放射性示踪剂的辅助剂,用于心肌应激成像。 | |||
T29112 | Adenosine Receptor | ||
VPC171 是一种新型腺苷 A1 受体正变构调节剂 (PAM)。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00891 | Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) | Human | HEK293 Cells | ||
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2.
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TMPY-02096 | TACI Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2.
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TMPY-04113 | KRAS Protein,Human,Recombinant(G12D & Q61H, His) | Human | E. coli | ||
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
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TMPY-01442 | DMBT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas , and ependymomas. DMBT1 may be considered as a candidate tumor suppressor for brain, lung, esophageal, gastric, and colorectal cancers. It may play roles in mucosal defense system, cellular immune defense and epithelial differentiation. DMBT1 may play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. It may be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. DMBT1 may function as a binding protein in saliva for the regulation of taste sensation. It binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.
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TMPY-02011 | CD96 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2.
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TMPY-01717 | VEGF164 Protein, Mouse, Recombinant | Mouse | Baculovirus Insect Cells | ||
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2.
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TMPY-00341 | FGFR3 Protein, Human, Recombinant (alpha IIIb, His) | Human | HEK293 Cells | ||
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2.
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TMPY-01613 | Periostin/OSF-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2.
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TMPJ-00850 | ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) | Mouse | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2.
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TMPY-03527 | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc) | Human | HEK293 Cells | ||
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.9 kDa and the accession number is O14788-2.
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TMPY-00701 | CD16b Protein, Human, Recombinant (NA2, HEK293, His) | Human | HEK293 Cells | ||
CD16b Protein, Human, Recombinant (NA2, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.2 kDa and the accession number is O75015.2.
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TMPY-01691 | Clusterin Protein, Human, Recombinant (CLU34, His) | Human | HEK293 Cells | ||
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2.
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TMPY-00751 | TrkB Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
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TMPY-05288 | PLGF/PGF Protein, Human, Recombinant (aa 19-149) | Human | E. coli | ||
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2.
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TMPY-04844 | BTN3A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2.
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TMPY-06056 | KRAS Protein, Human, Recombinant (G12D, His) | Human | E. coli | ||
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2.
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TMPY-02820 | SDF-1/CXCL12 Protein, Human, Recombinant (isoform a) | Human | E. coli | ||
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.
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TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPY-01935 | c-Kit Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
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TMPY-04644 | PDGFB Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P01127-2.
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TMPY-01985 | CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2.
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TMPY-04356 | GSK3B Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2.
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TMPY-02500 | YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2.
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TMPY-05414 | NKG2D/CD314 Protein, Mouse, Recombinant (hFc) | Mouse | Baculovirus Insect Cells | ||
NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2.
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TMPY-04424 | MST3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury.
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TMPY-01871 | IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) | Human | HEK293 Cells | ||
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2.
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TMPY-02792 | GDNF Protein, Human, Recombinant (HEK293) | Human | HEK293 Cells | ||
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
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TMPY-01359 | ST2/IL-1 RL1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2.
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TMPY-01888 | KRAS Protein,Human, Recombinant (Q61H, His) | Human | E. coli | ||
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2.
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TMPY-00747 | Nectin-2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
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TMPY-04051 | c-Kit Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2.
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TMPY-05427 | CD19 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2.
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TMPJ-00335 | TGFBR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2.
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TMPY-00127 | M-CSF/CSF1 Protein, Human, Recombinant | Human | HEK293 Cells | ||
M-CSF/CSF1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.4 kDa and the accession number is P09603-2.
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TMPY-02906 | CD16b Protein, Human, Recombinant (NA2, CHO, His) | Human | CHO Cells | ||
CD16b Protein, Human, Recombinant (NA2,His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 22.2 kDa and the accession number is O75015.2.
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TMPY-04116 | KRAS Protein,Human,Recombinant(G12C & Q61H, His) | Human | E. coli | ||
KRAS Protein,Human,Recombinant(G12C & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
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TMPY-02231 | TrkB Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2.
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TMPY-02432 | VEGF164 Protein, Rat, Recombinant | Rat | Baculovirus Insect Cells | ||
VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2.
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TMPY-00850 | ST2/IL-1 RL1 Protein, Human, Recombinant | Human | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2.
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TMPY-02367 | Neuropilin-1 Protein, Human, Recombinant (isoform b, His) | Human | HEK293 Cells | ||
Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2.
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TMPY-00849 | ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.72 kDa and the accession number is Q01638-2.
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TMPY-04829 | G-CSF Protein, Human, Recombinant | Human | HEK293 Cells | ||
G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2.
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TMPY-00871 | LAYN Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
LAYN Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.5 kDa and the accession number is Q6UX15-2.
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TMPY-01199 | CD74 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2.
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TMPY-00005 | FGF-8a Protein, Human, Recombinant | Human | E. coli | ||
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
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TMPY-02971 | CLEC10A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
CLEC10A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.6 kDa and the accession number is Q8IUN9-2.
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TMPY-05586 | CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent in mouse and rat genomes. The immunoglobulin domain of IGPR-1 was predicted to be Ig V (variable) fold and was found to be highly similar to the Ig domain of myelin-associated glycoprotein.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy. CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.3 kDa and the accession number is Q96BF3-2.
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TMPY-00748 | Nectin-2 Protein, Human, Recombinant | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
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TMPY-00392 | PAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
PAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 94.4 kDa and the accession number is P19021-2.
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TMPY-03425 | Tau Protein, Human, Recombinant (His) | Human | E. coli | ||
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.
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