目录号 | 产品详情 | 靶点 | |
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TP1516L | Others | ||
C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) 是 C-反应蛋白的 77-82 片段。 C-反应蛋白 (CRP) 是炎症的原型标志物,是心血管风险标志物,可能促进动脉粥样硬化。C-反应蛋白 (CRP) 是一种环状(环状)五聚体蛋白,存在于血浆中,其循环浓度炎症反应而升高。它是一种肝脏来源的急性期蛋白,在巨噬细胞和 T 细胞分泌 IL-6 后会增加。 | |||
T3891 | Others | ||
Oroxylin A-7-O-glucuronide (Oroxylin A Glucoronide) 是一种类黄酮葡糖苷酸,提取自 Scutellaria baicalensis 干燥的根中,具有脯氨酰寡肽酶(POP)抑制作用。 | |||
T38034 | Monoamine Oxidase | ||
MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) 是一种口服活性,可通过血脑屏障的,脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。 | |||
T3464 | GluR | ||
PHCCC ((-) PHCCC) 是 I 组代谢型谷氨酸受体拮抗剂和 mGluR4 的正变构调节剂。 它对 mGluR2 和 mGluR8 也有很强的拮抗作用,具有抗帕金森病作用。 | |||
T22264 | PARP | ||
AZ9482 是一种选择性 PARP1/2/6的三重抑制剂,IC50值分别为 1 、1 和640 nM。 | |||
TN7220 | Antibiotic | ||
2,5-Dihydroxy-1,4-benzoquinone 是一种天然产物,具有抗菌活性,可降低12个不同属6种真菌的营养生长并抑制孢子萌发。 | |||
T4S1962 | NF-κB JNK | ||
beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分,具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障,能够预防帕金森病。 | |||
T6S1917 | P450 Reactive Oxygen Species Autophagy | ||
Schisandrol B (Besigomsin) 是华中五味子的主要活性成分,具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生,也抑制 P-糖蛋白和CYP3A 的活性。 | |||
T7672 | TLR | ||
MD2-TLR4-IN-1 是一种骨髓分化蛋白 2/toll 样受体 4 (MD2-TLR4) 复合物抑制剂,能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达,IC50值分别为 0.89 和 0.53 μM。 | |||
T6S1049 | ATPase | ||
Wilforine 是一倍半萜吡啶化合物,T. wilfordii 植物中的重要生物活性化合物,可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03382 | FGF-6 Protein, Human, Recombinant | Human | E. coli | ||
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene displayed oncogenic transforming activity when transfected into mammalian cells.
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TMPY-00863 | IL-6 Protein, Human, Recombinant | Human | E. coli | ||
IL-6 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.95 kDa and the accession number is P05231.
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TMPY-03238 | IL-6 Protein, Mouse, Recombinant | Mouse | E. coli | ||
IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.
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TMPY-02118 | IGFBP-6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IGFBP-6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P47880.
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TMPY-03298 | IL-6 Protein, Rat, Recombinant | Rat | E. coli | ||
IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.
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TMPY-01050 | Cadherin 6/CDH6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Cadherin 6/CDH6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is P55285-1.
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TMPY-03327 | IL-6 Protein, Rhesus, Recombinant | Rhesus | E. coli | ||
IL-6 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21 kDa and the accession number is A0A1D5QRZ4.
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TMPY-04830 | GAS6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor progression by regulating growth in many cancers. GAS6, expressed by osteoblasts in the bone marrow, plays a significant role in the regulation of PCa cell survival during chemotherapy, which will have important implications for targeting metastatic disease. The GAS6/TYRO3-AXL-MERTK (TAM) signaling pathway is essential for full and sustained platelet activation, as well as thrombus stabilization. Inhibition of this pathway decreases platelet aggregation, shape change, clot retraction, aggregate formation under flow conditions, and surface expression of activation markers. It had been show that GAS6 signaling regulates invasion, proliferation, chemotherapy-induced apoptosis of prostate cancer (PCa) cells, and GAS6 secreted from osteoblasts in the bone marrow environment plays a critical role in establishing prostate tumor cell dormancy.
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TMPY-06077 | LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.3 kDa and the accession number is O75019-1.
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TMPY-04782 | LILRA1/LIR-6/CD85i Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is O75019-1.
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TMPY-01214 | IL-6R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-6R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is P22272.
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TMPY-00369 | LY6D Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. The expression of LY6D is induced in MCF10A cells by X-ray irradiation. The induction of LY6D expression is triggered through a pathway regulated by ATM, CHK2, and p53. This method is a new Ab-directed proteomic strategy for the analysis of membrane proteins and applies to various biological phenomena in situations in which both target molecule-expressing cells and nonexpressing cells are available. Diseases associated with LY6D include Alzheimer's Disease 16 and Inferior Myocardial Infarction.
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TMPY-01832 | gp130/IL6ST Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
gp130/IL6ST Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q00560.
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TMPY-01076 | gp130/IL6ST Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
gp130/IL6ST Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 96 kDa and the accession number is P40189-1.
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TMPY-05850 | CEACAM6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CEACAM6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.3 kDa and the accession number is XP_005589488.1.
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TMPY-00864 | IL-6R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-6R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is A0N0L5.
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TMPY-05278 | IL-6R Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
IL-6R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.3 kDa and the accession number is A0N0L5.
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TMPY-03878 | Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells | ||
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
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TMPY-02603 | STAT6 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB.
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TMPY-04643 | Integrin alpha V beta 6 Protein, Mouse, Recombinant (Flag & His) | Mouse | HEK293 Cells | ||
Integrin alpha V beta 6 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is NP_032428.2&NP_067334.1.
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TMPY-06586 | Claudin-6 Protein, Human, Recombinant | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.30 kDa and the accession number is NP_067018.2.
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TMPY-00971 | CEACAM6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CEACAM6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.
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TMPY-04271 | Frizzled 6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Frizzled 6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is A0A024R9E9.
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TMPY-06805 | Claudin-6 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 21.87 kDa and the accession number is P56747.
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TMPY-00577 | Frizzled 6 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Frizzled 6 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42 kDa and the accession number is A0A024R9E9.
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TMPY-06766 | Claudin-6 Protein, Human, Recombinant, Fluorescent,VLP | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant, Fluorescent,VLP is expressed in HEK293 mammalian cells. The predicted molecular weight is 50.31 kDa and the accession number is P56747.
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TMPH-00334 | Candidapepsin-6 Protein, Candida albicans, Recombinant (His) | Candida albicans | E. coli | ||
Candidapepsin-6 Protein, Candida albicans, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is P43095.
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TMPY-02931 | Cadherin 6/CDH6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Cadherin 6/CDH6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68.7 kDa and the accession number is P97326.
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TMPY-06965 | Claudin-6 Protein, Human, Recombinant (GFP & His) | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant (GFP & His) is expressed in HEK293 mammalian cells with GFP and His tag. The predicted molecular weight is 23.3 kDa and the accession number is P56747-1.
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TMPY-06851 | Claudin-6 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 22.7 kDa and the accession number is P56747.
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TMPK-01249 | Claudin-6 Protein-VLP, Mouse, Recombinant | Mouse | HEK293 Cells | ||
Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively. Claudin-6 Protein-VLP, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.60 kDa and the accession number is Q9Z262.
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TMPY-06698 | LRP-6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
LRP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.41 kDa and the accession number is O75581-1.
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TMPY-06834 | LRP-6 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
LRP-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.69 kDa and the accession number is O75581.
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TMPJ-00780 | IFN-alpha 6/IFNA6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Interferon α-6 (IFN-α6) is a secreted protein which belongs to the α/β interferon family. IFN-α6 is produced by macrophages, expressed at low level, only 1.0% of the average gene in this release. IFN-α6 contains interferon alpha, beta and delta domain. IFN-α has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
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TMPY-00311 | Cadherin 6/CDH6 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Cadherin 6/CDH6 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.9 kDa and the accession number is A6KJN4.
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TMPY-05347 | Cadherin 6/CDH6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Cadherin 6/CDH6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.5 kDa and the accession number is XP_005556691.1.
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TMPK-00904 | Claudin-6 Protein-VLP, Human, Recombinant | Human | HEK293 Cells | ||
Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively. Claudin-6 Protein-VLP, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.5 kDa and the accession number is P56747.
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TMPY-02158 | Integrin alpha 6 beta 1 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells | ||
Integrin alpha 6 beta 1 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 198 kDa and the accession number is P23229-3&P05556-1.
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TMPY-04513 | IGFBP-6 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IGFBP-6 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.9 kDa and the accession number is A6KCS9.
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TMPY-02119 | IGFBP-6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IGFBP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.9 kDa and the accession number is P24592.
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TMPK-00744 | LRP-6 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin.
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TMPY-02121 | CXADR/CAR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CXADR/CAR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is P78310-1.
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TMPK-00667 | Claudin-6 Protein-VLP, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively. Claudin-6 Protein-VLP, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.60 kDa and the accession number is G7Q0B0.
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TMPH-01018 | BMP-6 Protein, Human, Recombinant (His) | Human | E. coli | ||
BMP-6 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.9 kDa and the accession number is P22004.
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TMPY-00344 | ARL6IP6 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
It had been found that a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular malformations. This gene was previously implicated by genome wide association study (GWAS) as a susceptibility locus to ischemic stroke in young adults. We identify ARL6IP6 as a novel candidate gene for a syndromic form of CMTC. This suggests that ischemic stroke or transient ischemic attacks (TIA) may represent, at least in some cases, the mild end of a phenotypic spectrum that has at its severe end autosomal recessive CMTC. This finding contributes to a growing appreciation of the continuum of Mendelian and common complex diseases.
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TMPH-00474 | Der p 6 Protein, Dermatophagoides pteronyssinus, Recombinant (GST) | Dermatophagoides pteronyssinus | E. coli | ||
Der p 6 Protein, Dermatophagoides pteronyssinus, Recombinant (GST) is expressed in E. coli.
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TMPY-04183 | IL-6 Protein, Sus scrofa (Pig), Recombinant | Sus scrofa (Pig) | E. coli | ||
IL-6 Protein, Sus scrofa (Pig), Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.2 kDa and the accession number is A4D862.
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TMPK-00101 | IL-6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein.
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TMPK-00839 | ITGB6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5' untranslated region (5'UTR) of the bovine ITGB6 gene. ITGB6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 75.4 kDa and the accession number is P18564-1.
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TMPY-02759 | Kallikrein 6/KLK6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein, and extracellular matrix proteins such as fibronectin, laminin, vitronectin, and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson's disease and other synucleinopathies. Klk7 may be involved in the regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
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