Claudin-6 Protein, Human, Recombinant

Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It regulates the paracellular flux of cations in the kidney through forming heterotypic strands with other claudins and has a role in maintaining the lung epithelial barrier function. The CLDN6 gene is adjacent to another family member, CLDN9, on chromosome 16. Certain CLDN6-positive cancers, encompassing ovarian, endometrial, and testicular malignancies, have been shown to have their proliferation and invasiveness suppressed upon CLDN6 silencing.

规格	价格/CNY		数量
20 μg	￥ 5,330	5日内发货
100 μg	￥ 10,600	5日内发货
500 μg	￥ 33,800	5日内发货

规格

价格/CNY

货期

数量

20 μg

￥ 5,330

5日内发货

100 μg

￥ 10,600

5日内发货

500 μg

￥ 33,800

5日内发货

生物活性

Immobilized Human CLDN6-VLP (Full Length) Protein at 5 μg/mL (100 μL/well) can bind Anti-Human CLDN6 Antibody, Human IgG1, the EC50 is 2-10 ng/mL.

产品描述

种属	Human
表达系统	HEK293
标签	Tag Free
蛋白编号	NP_067018.2
别名	claudin 6
蛋白构建	A DNA sequence encoding the human CLDN6 (NP_067018.2) (Met1-Val220) was expressed.
分子量	23.30 kDa (predicted)

内毒素	< 1.0 EU per μg protein as determined by the LAL method.
缓冲液	Supplied as sterile solution in 50mM HEPES, 150mM NaCI, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
存储	Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
运输方式	It is supplied and shipped as Solution with dry ice.
研究背景	Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It regulates the paracellular flux of cations in the kidney through forming heterotypic strands with other claudins and has a role in maintaining the lung epithelial barrier function. The CLDN6 gene is adjacent to another family member, CLDN9, on chromosome 16. Certain CLDN6-positive cancers, encompassing ovarian, endometrial, and testicular malignancies, have been shown to have their proliferation and invasiveness suppressed upon CLDN6 silencing.