Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) 是一种口服活性,可通过血脑屏障的,脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 396 | 现货 | ||
5 mg | ¥ 828 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 1,980 | 现货 | ||
50 mg | ¥ 3,150 | 现货 | ||
100 mg | ¥ 4,480 | 现货 | ||
500 mg | ¥ 9,330 | 现货 |
产品描述 | MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model. |
靶点活性 | MAO-A:37 nM (IC50), MAO-B:57 nM (IC50) |
体外活性 | MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells[3]. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival[4]. |
体内活性 | MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities[6]. |
别名 | M 30 dihydrochloride |
分子量 | 299.2 |
分子式 | C14H16Cl2N2O |
CAS No. | 64821-19-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1.8 mg/mL (6 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3422 mL | 16.7112 mL | 33.4225 mL | 83.5561 mL |
5 mM | 0.6684 mL | 3.3422 mL | 6.6845 mL | 16.7112 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MAO-IN-M30 dihydrochloride 64821-19-8 Neuroscience Monoamine Oxidase M 30 Dihydrochloride M 30 dihydrochloride M 30 MAO-IN-M30 M-30 Dihydrochloride M30 M-30 MAO-IN-M30 Dihydrochloride M30 Dihydrochloride Inhibitor inhibitor inhibit