目录号 | 产品详情 | 靶点 | |
---|---|---|---|
T12821 | LPL Receptor | ||
S1PR1 modulator 1 是 S1PR1 的特异性抑制剂,pIC50 为 7.6。 | |||
T4S0797 | Reactive Oxygen Species Topoisomerase Endogenous Metabolite Antibacterial Antibiotic Autophagy | ||
Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。 | |||
T0798 | Glucocorticoid Receptor COX | ||
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
T1659 | CaMK Apoptosis Mitophagy Estrogen/progestogen Receptor Melatonin Receptor Glutathione Peroxidase Endogenous Metabolite ROR Autophagy | ||
Melatonin (Melatonine) 是一种由松果体制成的激素,可激活褪黑激素受体。它在睡眠中起作用,有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂,可诱导细胞凋亡。 | |||
T5558 | NF-κB Caspase | ||
Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质,用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂,Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。 | |||
T1756L | Proton pump TOPK | ||
Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂,以剂量依赖性方式不可逆地抑制H+/K+-ATPase,在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂,用于胃溃疡的研究。 | |||
T2S2264 | Apoptosis IL Receptor TNF Endogenous Metabolite iGluR | ||
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
T2S0843 | IL Receptor TNF NOS Interleukin | ||
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。 | |||
T2548 | Glucocorticoid Receptor | ||
Diflorasone 是一种皮质类固醇激素受体激动剂,具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞,并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。 | |||
T2S1865 | Antioxidant Influenza Virus Reactive Oxygen Species Antibacterial Antifungal HSV | ||
Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用,有选择性和敏感性的荧光特性,广泛用作食品添加剂。它对 HSV-1,水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPY-03382 | FGF-6 Protein, Human, Recombinant | Human | E. coli | ||
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene displayed oncogenic transforming activity when transfected into mammalian cells.
|
|||||
TMPY-00863 | IL-6 Protein, Human, Recombinant | Human | E. coli | ||
IL-6 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.95 kDa and the accession number is P05231.
|
|||||
TMPY-03238 | IL-6 Protein, Mouse, Recombinant | Mouse | E. coli | ||
IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.
|
|||||
TMPY-02118 | IGFBP-6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IGFBP-6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P47880.
|
|||||
TMPY-03298 | IL-6 Protein, Rat, Recombinant | Rat | E. coli | ||
IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.
|
|||||
TMPY-01050 | Cadherin 6/CDH6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Cadherin 6/CDH6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is P55285-1.
|
|||||
TMPY-03327 | IL-6 Protein, Rhesus, Recombinant | Rhesus | E. coli | ||
IL-6 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21 kDa and the accession number is A0A1D5QRZ4.
|
|||||
TMPY-04830 | GAS6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor progression by regulating growth in many cancers. GAS6, expressed by osteoblasts in the bone marrow, plays a significant role in the regulation of PCa cell survival during chemotherapy, which will have important implications for targeting metastatic disease. The GAS6/TYRO3-AXL-MERTK (TAM) signaling pathway is essential for full and sustained platelet activation, as well as thrombus stabilization. Inhibition of this pathway decreases platelet aggregation, shape change, clot retraction, aggregate formation under flow conditions, and surface expression of activation markers. It had been show that GAS6 signaling regulates invasion, proliferation, chemotherapy-induced apoptosis of prostate cancer (PCa) cells, and GAS6 secreted from osteoblasts in the bone marrow environment plays a critical role in establishing prostate tumor cell dormancy.
|
|||||
TMPY-06077 | LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.3 kDa and the accession number is O75019-1.
|
|||||
TMPY-04782 | LILRA1/LIR-6/CD85i Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is O75019-1.
|
|||||
TMPY-01214 | IL-6R Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-6R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is P22272.
|
|||||
TMPY-00369 | LY6D Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. The expression of LY6D is induced in MCF10A cells by X-ray irradiation. The induction of LY6D expression is triggered through a pathway regulated by ATM, CHK2, and p53. This method is a new Ab-directed proteomic strategy for the analysis of membrane proteins and applies to various biological phenomena in situations in which both target molecule-expressing cells and nonexpressing cells are available. Diseases associated with LY6D include Alzheimer's Disease 16 and Inferior Myocardial Infarction.
|
|||||
TMPY-01832 | gp130/IL6ST Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
gp130/IL6ST Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q00560.
|
|||||
TMPY-01076 | gp130/IL6ST Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
gp130/IL6ST Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 96 kDa and the accession number is P40189-1.
|
|||||
TMPY-05850 | CEACAM6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CEACAM6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.3 kDa and the accession number is XP_005589488.1.
|
|||||
TMPY-00864 | IL-6R Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-6R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is A0N0L5.
|
|||||
TMPY-05278 | IL-6R Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
IL-6R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.3 kDa and the accession number is A0N0L5.
|
|||||
TMPY-03878 | Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells | ||
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
|
|||||
TMPY-02603 | STAT6 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB.
|
|||||
TMPY-04643 | Integrin alpha V beta 6 Protein, Mouse, Recombinant (Flag & His) | Mouse | HEK293 Cells | ||
Integrin alpha V beta 6 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is NP_032428.2&NP_067334.1.
|
|||||
TMPY-06586 | Claudin-6 Protein, Human, Recombinant | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.30 kDa and the accession number is NP_067018.2.
|
|||||
TMPY-00971 | CEACAM6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CEACAM6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.
|
|||||
TMPY-04271 | Frizzled 6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Frizzled 6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is A0A024R9E9.
|
|||||
TMPY-06805 | Claudin-6 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 21.87 kDa and the accession number is P56747.
|
|||||
TMPY-00577 | Frizzled 6 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Frizzled 6 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42 kDa and the accession number is A0A024R9E9.
|
|||||
TMPH-00334 | Candidapepsin-6 Protein, Candida albicans, Recombinant (His) | Candida albicans | E. coli | ||
Candidapepsin-6 Protein, Candida albicans, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is P43095.
|
|||||
TMPY-06766 | Claudin-6 Protein, Human, Recombinant, Fluorescent,VLP | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant, Fluorescent,VLP is expressed in HEK293 mammalian cells. The predicted molecular weight is 50.31 kDa and the accession number is P56747.
|
|||||
TMPY-02931 | Cadherin 6/CDH6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Cadherin 6/CDH6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68.7 kDa and the accession number is P97326.
|
|||||
TMPY-06965 | Claudin-6 Protein, Human, Recombinant (GFP & His) | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant (GFP & His) is expressed in HEK293 mammalian cells with GFP and His tag. The predicted molecular weight is 23.3 kDa and the accession number is P56747-1.
|
|||||
TMPY-06851 | Claudin-6 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Claudin-6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 22.7 kDa and the accession number is P56747.
|
|||||
TMPK-01249 | Claudin-6 Protein-VLP, Mouse, Recombinant | Mouse | HEK293 Cells | ||
Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively. Claudin-6 Protein-VLP, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.60 kDa and the accession number is Q9Z262.
|
|||||
TMPY-06698 | LRP-6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
LRP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.41 kDa and the accession number is O75581-1.
|
|||||
TMPY-06834 | LRP-6 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
LRP-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95.69 kDa and the accession number is O75581.
|
|||||
TMPJ-00780 | IFN-alpha 6/IFNA6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Interferon α-6 (IFN-α6) is a secreted protein which belongs to the α/β interferon family. IFN-α6 is produced by macrophages, expressed at low level, only 1.0% of the average gene in this release. IFN-α6 contains interferon alpha, beta and delta domain. IFN-α has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
|
|||||
TMPY-00311 | Cadherin 6/CDH6 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Cadherin 6/CDH6 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.9 kDa and the accession number is A6KJN4.
|
|||||
TMPY-05347 | Cadherin 6/CDH6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Cadherin 6/CDH6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.5 kDa and the accession number is XP_005556691.1.
|
|||||
TMPK-00904 | Claudin-6 Protein-VLP, Human, Recombinant | Human | HEK293 Cells | ||
Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively. Claudin-6 Protein-VLP, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.5 kDa and the accession number is P56747.
|
|||||
TMPY-02158 | Integrin alpha 6 beta 1 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells | ||
Integrin alpha 6 beta 1 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 198 kDa and the accession number is P23229-3&P05556-1.
|
|||||
TMPY-04513 | IGFBP-6 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
IGFBP-6 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.9 kDa and the accession number is A6KCS9.
|
|||||
TMPY-02119 | IGFBP-6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IGFBP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.9 kDa and the accession number is P24592.
|
|||||
TMPK-00744 | LRP-6 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/β-catenin.
|
|||||
TMPY-02121 | CXADR/CAR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CXADR/CAR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is P78310-1.
|
|||||
TMPK-00667 | Claudin-6 Protein-VLP, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively. Claudin-6 Protein-VLP, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.60 kDa and the accession number is G7Q0B0.
|
|||||
TMPH-01018 | BMP-6 Protein, Human, Recombinant (His) | Human | E. coli | ||
BMP-6 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.9 kDa and the accession number is P22004.
|
|||||
TMPY-00344 | ARL6IP6 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
It had been found that a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular malformations. This gene was previously implicated by genome wide association study (GWAS) as a susceptibility locus to ischemic stroke in young adults. We identify ARL6IP6 as a novel candidate gene for a syndromic form of CMTC. This suggests that ischemic stroke or transient ischemic attacks (TIA) may represent, at least in some cases, the mild end of a phenotypic spectrum that has at its severe end autosomal recessive CMTC. This finding contributes to a growing appreciation of the continuum of Mendelian and common complex diseases.
|
|||||
TMPH-00474 | Der p 6 Protein, Dermatophagoides pteronyssinus, Recombinant (GST) | Dermatophagoides pteronyssinus | E. coli | ||
Der p 6 Protein, Dermatophagoides pteronyssinus, Recombinant (GST) is expressed in E. coli.
|
|||||
TMPY-04183 | IL-6 Protein, Sus scrofa (Pig), Recombinant | Sus scrofa (Pig) | E. coli | ||
IL-6 Protein, Sus scrofa (Pig), Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.2 kDa and the accession number is A4D862.
|
|||||
TMPK-00101 | IL-6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein.
|
|||||
TMPK-00839 | ITGB6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5' untranslated region (5'UTR) of the bovine ITGB6 gene. ITGB6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 75.4 kDa and the accession number is P18564-1.
|
|||||
TMPY-02759 | Kallikrein 6/KLK6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein, and extracellular matrix proteins such as fibronectin, laminin, vitronectin, and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson's disease and other synucleinopathies. Klk7 may be involved in the regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
|