目录号 | 产品详情 | 靶点 | |
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T3S0153 | Apoptosis VEGFR Lipoxygenase Wnt/beta-catenin Antibacterial | ||
Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物,可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL,对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。 | |||
T1449 | Potassium Channel Carbonic Anhydrase TGF-beta/Smad | ||
Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药,可抑制转化 TGF-β/Smad 信号通路。它通过打开钙激活钾 (KCA) 通道发挥直接的血管松弛作用。它改善心脏功能,减少纤维化并具有降压作用。 | |||
T0145 | Calcium Channel Autophagy | ||
Felodipine (CGH-869) 是一种长效的 1, 4-二氢吡啶钙通道抑制剂,可跨越血脑屏障,可诱导自噬,具有抗高血压活性。它通过选择性作用于血管平滑肌,尤其是阻力血管来降低血压。 | |||
T1754 | VEGFR Bcr-Abl Src | ||
ZM 306416 (CB 676475) 是一种 VEGFR 的有效抑制剂,能够抑制 KDR (IC50:0.1 μM) 和 Flt (IC50:2 μM),也是一种 EGFR 的抑制剂(IC50<10 nM)。 | |||
T4026 | VEGFR | ||
SU5408 (VEGFR2 Kinase Inhibitor I) 是一种可渗透细胞的VEGFR2激酶抑制剂,其IC50=70 nM。 | |||
TQ0317 | VEGFR FGFR FLT PDGFR | ||
R1530 是一种多激酶抑制剂,具有抗肿瘤和抗血管生成活性。它是具有口服活性的有丝分裂/血管生成高效双重作用抑制剂, 抑制 VGFR2、FGFR1作用的 IC50分别为 10 nM 和 28 nM。 | |||
T2288 | VEGFR c-Kit | ||
Motesanib (AMG 706) 是有效的、ATP 竞争性的 VEGFR1/2/3 的抑制剂,其IC50值为 2 nM/3 nM/6 nM,与对 Kit 的选择性相似,是 PDGFR 和 Ret 的 10 倍多。 | |||
T5194 | Serine/threonin kinase | ||
SPHINX31 是丝氨酸/富含精氨酸的蛋白激酶1的选择性抑制剂,其IC50值为 5.9 nM。它有效抑制丝氨酸/丰富精氨酸的剪接因子1 磷酸化,有用于局部新生血管性眼病的研究潜力。 | |||
T22459 | Others | ||
Xanthinol Nicotinate (Complamin) 是血管扩张剂,可直接作用于小动脉和毛细血管的平滑肌,能够扩大血管,改善血液流变学并降低外周血管阻力。 | |||
T2415 | Apoptosis VEGFR Bcr-Abl PDGFR Src mTOR Hck | ||
PP121是一种多靶点激酶抑制剂,抑制 PDGFR、Hck、mTOR、VEGFR2、Src、Abl、DNK-PK 的 IC50值分别为2、8、10、12、14、18、60 nM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-03156 | VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) | Mouse,Rat | HEK293 Cells | ||
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.5 kDa and the accession number is P97953-1.
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TMPJ-00865 | VEGF121 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessels and endothelial cell growth, increasing microvascular permeability, promoting cell migration and inhibiting apoptosis. Alternatively spliced transcript variants of VEGF-A encod either secreted or cell-associated isoforms. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
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TMPY-01830 | VCAM-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
VCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 75.8 kDa and the accession number is Q3UPN1.
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TMPY-03698 | VEGF121b Protein, Human, Recombinant | Human | HEK293 Cells | ||
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
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TMPY-02432 | VEGF164 Protein, Rat, Recombinant | Rat | Baculovirus Insect Cells | ||
VEGF164 Protein, Rat, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is P16612-2.
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TMPY-04911 | VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated | Human,Cynomolgus | HEK293 Cells | ||
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4.
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TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinase domain. VEGFR-1is an essential receptor tyrosine kinase and plays an important role in theregulation of VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. It is also mediators of neurotrophic activity and regulators of hematopoietic development. VEGFR-1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF.It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells and promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. VEGFR-1 can also promote PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
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TMPY-00947 | VCAM-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1.
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TMPY-01717 | VEGF164 Protein, Mouse, Recombinant | Mouse | Baculovirus Insect Cells | ||
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2.
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TMPJ-00864 | VEGF165 Protein, Human, Recombinant | Human | HEK293 Cells | ||
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimulates the cellular response through binding to tyrosine kinase receptors VEGFR1 and VEGFR2 on the cell surface. It is widely accepted that VEGFR2 mediate almost all of the known cellular responses to VEGF while the function of VEGFR1 is less defined and is thought to modulate the VEGFR2 signaling.
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TMPY-01008 | VEGFD Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915.
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TMPY-01007 | VEGFC Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VEGFC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is P49767.
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TMPJ-00603 | TL1A/TNFSF15 Protein, Mouse, Recombinant | Mouse | E. coli | ||
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
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TMPY-03155 | VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc) | Mouse,Rat | HEK293 Cells | ||
VEGFC Protein, Mouse/Rat, Recombinant (aa 108-223, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 41.5 kDa and the accession number is O35757.
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TMPJ-00930 | VCAM-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction.
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TMPY-03305 | VE-Cadherin Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
VE-Cadherin Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 65.1 kDa and the accession number is A6JXX3.
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TMPY-01677 | VE-Cadherin Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
VE-Cadherin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 92 kDa and the accession number is P33151-1.
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TMPY-01144 | VCAM-1 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
VCAM-1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 102 kDa and the accession number is Q3UPN1.
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TMPJ-00844 | ANXA8 Protein, Human, Recombinant | Human | E. coli | ||
Annexin A8 (ANXA8) belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Annexin A8 contains 4 annexin repeats separated by linking sequences of variable lengths. A pair of annexin repeats may form one binding site for calcium and phospholipid. ANXA8 is preferentially expressed in acute promyelocytic leukemia (APL) cells, which suggests its participation in hematopoietic cell differentiation. In addition, ANXA8 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
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TMPY-05616 | VCAM-1 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells | ||
VCAM-1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P19320-1.
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TMPY-03080 | VEGF165 Protein, Danio rerio (zebrafish), Recombinant | Danio rerio (zebrafish) | Baculovirus Insect Cells | ||
VEGF165 Protein, Danio rerio (zebrafish), Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is O73682.
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TMPY-03200 | VEGFD Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
VEGFD Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.6 kDa and the accession number is O35251.
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TMPY-03705 | VEGF164 Protein, Canine, Recombinant | Canine | HEK293 Cells | ||
VEGF164 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9MYV3-3.
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TMPY-04327 | VEGFB Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang II-induced rising in Ca2+.
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TMPY-00948 | VCAM-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VCAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76 kDa and the accession number is P19320-1.
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TMPY-06916 | VCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
VCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 77.36 kDa and the accession number is NP_001069.1.
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TMPY-01656 | VEGF183 Protein, Human, Recombinant | Human | Baculovirus Insect Cells | ||
VEGF183 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 21 kDa and the accession number is P15692-3.
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TMPY-01237 | VE-Cadherin Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
VE-Cadherin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 63.5 kDa and the accession number is P55284.
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TMPJ-00377 | VCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells | ||
VCAM-1 (CD106, INCAM-110) is a cell adhesion molecule and a member of the immunoglobulin superfamily. It's important function is a recognition of cell-cell. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation。
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TMPH-00949 | APOLD1 Protein, Human, Recombinant (His) | Human | E. coli | ||
May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. APOLD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 33.4 kDa and the accession number is Q96LR9.
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TMPY-03150 | VEGFD Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
VEGFD Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14 kDa and the accession number is P97946.
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TMPY-02589 | VEGFD Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
VEGFD Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P97946.
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TMPY-05798 | VEGF145 Protein, Human, Recombinant | Human | HEK293 Cells | ||
VEGF145 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.92 kDa and the accession number is P15692-6.
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TMPH-03272 | Complement factor D Protein, Rat, Recombinant (His) | Rat | P. pastoris (Yeast) | ||
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
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TMPH-03271 | Complement factor D Protein, Rat, Recombinant (His & Myc) | Rat | HEK293 Cells | ||
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038.
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TMPJ-00379 | AOC3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflammation. This rise in metabolic products contributes to generating advanced glycation end-products and oxidative stress along with the monoamine detoxification in the organism. It is highly expressed on the endothelium of the lung and trachea, and absent from leukocytes and epithelial cells. Membrane-bound VAP-1 releases an active, soluble form of the protein, which may be conducive to increased inflammation and the progression of many vascular disorders. In particular, elevation of VAP-1 activity and the increased enzymatic-mediated deamination is proposed to play a role in renal and vascular disease, oxidative stress, acute and chronic hyperglycemia, and diabetes complications.
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TMPJ-00380 | AOC3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. VAP-1 vascular expression is regulated at sites of inflammation through its release from intracellular granules in which the protein is stored. The adhesive function of VAP-1 has been demonstrated in studies showing that the protein is important for the adherence of certain lymphocyte subtypes to inflamed endothelial tissues. VAP-1 mediated adhesion is involved in the process of leukocyte extravasation, an important feature of inflammatory responses. VAP-1 is considered to be a therapeutic target for diabetes, oxidative stress, and inflammatory diseases.
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TMPJ-00414 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated | Human | HEK293 Cells | ||
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 120-150 KDa and the accession number is P35968.
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TMPJ-01031 | JAM-B Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
JAM-B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-39 KDa and the accession number is P57087.
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TMPJ-01030 | JAM-B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
JAM-B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-75 KDa and the accession number is P57087.
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TMPJ-00593 | VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) | Human | HEK293 Cells | ||
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 110-140 KDa and the accession number is AAI31823.1.
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TMPK-00823 | VEGF165 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
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TMPY-01075 | Von Willebrand Factor/vWF Protein, Human, Recombinant (His) | Human | CHO Cells | ||
Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vascular injury. From studies it appears that VWF protein uncoils under these circumstances, decelerating passing platelets. VWF protein is deficient or defective in von Willebrand disease (VWD) and is involved in a large number of other diseases, including thrombosis, thrombotic thrombocytopenic purpura, Stroke, Heyde's syndrome, possibly hemolytic-uremic syndrome and so on.
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TMPY-04644 | PDGFB Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 14.3 kDa and the accession number is P01127-2.
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TMPY-05054 | Notch 4 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The NOTCH4 gene is located at 6p21.3 and is involved in the development and patterning of the central nervous systems. It regulates signaling pathways associated with neuronal maturation, a process involved in the development and patterning of the central nervous system. The NOTCH4 gene has also been identified as a possible susceptibility gene for schizophrenia (SCZ). It is broadly expressed in fat, lung, and other tissues. The NOTCH4 gene, located within the MHC region, is involved in cellular differentiation and has varying effects dependent on tissue type.
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TMPJ-00562 | PDGF-BB Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor,it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. It is required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. PDGFB also plays an important role in wound healing.
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TMPK-00359 | Endoglin/CD105 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis.
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TMPK-01073 | CLEC14A Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be expressed in vascular endothelial cells during embryogenesis and is also implicated in tumor angiogenesis.
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TMPK-00826 | VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
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TMPK-00489 | TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 21.52 kDa and the accession number is A0A2K5UA22.
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