HIF-1化合物库

HIF-1 Signaling Pathway Compound Library

产品编号： L8500

“氧感知通路”于2019年获诺贝尔生理学或医学奖，作为一种关键的调控蛋白，低氧诱导因子-1(hypoxia inducible factor-1，HIF-1)受到广泛关注，其普遍存在于人和哺乳动物细胞内，有相当广泛的靶基因谱，其中包括与缺氧适应、炎症发展及肿瘤生长等相关的近100种靶基因。

低氧诱导因子（HIF-1）在人类的代谢调节中，属于一个核心角色。在细胞中，HIF 信号级联反应会受到缺氧状态的影响。在缺氧状态下，通常会让细胞持续的细胞分化。然而，缺氧状态促进了血管新生，对于胚胎中的血管系统与癌症肿瘤来说非常重要。伤口处的缺氧状态，也促进了角质细胞的移动与上皮组织的修护。在普遍情况下，HIF 也是发育的重要关键。在哺乳动物中，若缺少了HIF-1的基因，将导致胎儿死亡。HIF-1已经被证实，对于软骨细胞的存亡有重大的影响，它能使软骨细胞适应在骨骼间生长板的缺氧环境。

揭示生物氧气感知通路，不仅在基础科学上有其价值，还有望带来创新的疗法。比如倘若能通过调控HIF-1通路，促进红细胞的生成，就有望治疗贫血。而干扰HIF-1的降解，则能促进血管生成，治疗循环不良。另一方面，由于肿瘤的生成离不开新生血管，如果能降解HIF-1α或相关蛋白（如HIF-2α），就有望对抗恶性肿瘤。

为满足研究“氧感知通路”相关客户的需求，TargetMol 收集了1352 个HIF-1相关的小分子，涉及PI3K-AKT, MAPK, Ubiquitination 等信号通路及HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome 等靶点，可用于氧感知通路的相关药物开发和药理研究。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

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陶术生物化合物库目录(28.1MB)

库化合物信息

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产品描述

1352个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；
涉及PI3K-AKT、MAPK、Ubiquitination等信号通路及HIF, HIF Prolyl-Hydroxylase, E1/E2/E3 Enzyme, PI3K, MAPK, Proteasome等靶点；
部分化合物已进入临床或经FDA批准上市；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

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化合物库组成

Apoptosis (305)

Autophagy (237)

PI3K (152)

NF-κB (126)

COX (83)

Akt (82)

ERK (78)

p38 MAPK (74)

mTOR (73)

HDAC (62)

Endogenous Metabolite (60)

Raf (59)

Proteasome (56)

Ras (53)

TNF (52)

Src (47)

Antibacterial (46)

JNK (41)

E1/E2/E3 Enzyme (40)

MEK (40)

AMPK (39)

GSK-3 (39)

HIF/HIF Prolyl-Hydroxylase (36)

CDK (35)

MAPK (34)

Reactive Oxygen Species (33)

DUB (31)

IL Receptor (29)

DNA-PK (28)

Ferroptosis (28)

S6 Kinase (28)

VEGFR (28)

HIF (26)

Sirtuin (24)

Caspase (23)

IκB/IKK (23)

TGF-beta/Smad (23)

ROS (22)

Influenza Virus (21)

HIV Protease (20)

ATM/ATR (19)

Bcr-Abl (19)

p53 (19)

TLR (19)

DPP-4 (18)

HSP (18)

EGFR (17)

Mitophagy (17)

STAT (16)

Antibiotic (15)

c-Kit (15)

PDGFR (15)

PKC (15)

FLT (14)

Mdm2 (14)

Parasite (14)

Virus Protease (14)

Antioxidant (13)

PPAR (13)

Antifungal (12)

Aurora Kinase (12)

Interleukin (12)

MMP (12)

P450 (12)

Casein Kinase (11)

DNA/RNA Synthesis (11)

Gamma-secretase (11)

JAK (11)

PKA (11)

Rho (11)

ALK (10)

FGFR (10)

NOD (10)

PERK (10)

Dehydrogenase (9)

PDK (9)

ROCK (9)

Beta Amyloid (8)

c-RET (8)

HSV (8)

Lipoxygenase (8)

Potassium Channel (8)

BCL (7)

NO Synthase (7)

NOD-like Receptor (NLR) (7)

PARP (7)

PDE (7)

PI4K (7)

SARS-CoV (7)

Tyrosine Kinases (7)

AChE (6)

IGF-1R (6)

Mitochondrial Metabolism (6)

MLK (6)

MNK (6)

p97 (6)

RIP kinase (6)

Serine Protease (6)

Trk receptor (6)

Adenosine Receptor (5)

Adrenergic Receptor (5)

Calcium Channel (5)

Cannabinoid Receptor (5)

FAK (5)

Glucokinase (5)

NOS (5)

TOPK (5)

Tyrosinase (5)

Wnt/beta-catenin (5)

Xanthine Oxidase (5)

Aryl Hydrocarbon Receptor (4)

ASK (4)

BTK (4)

c-Fms (4)

Chk (4)

c-Met/HGFR (4)

Cysteine Protease (4)

Glutathione Peroxidase (4)

HBV (4)

HCV Protease (4)

Nrf2 (4)

P-gp (4)

Phosphatase (4)

SGK (4)

Sodium Channel (4)

AChR (3)

Antiviral (3)

BACE (3)

Carbonic Anhydrase (3)

Drug Metabolite (3)

Epigenetic Reader Domain (3)

Estrogen/progestogen Receptor (3)

GABA Receptor (3)

IAP (3)

Integrin (3)

LRRK2 (3)

Phospholipase (3)

PLK (3)

Proton pump (3)

PTEN (3)

SGLT (3)

SIK (3)

Syk (3)

Topoisomerase (3)

TRP/TRPV Channel (3)

ACK (2)

AhR (2)

Aminopeptidase (2)

Aromatase (2)

Beta-Secretase (2)

BMI-1 (2)

Chloride channel (2)

CSF-1R (2)

DNA (2)

DNA Alkylation (2)

Estrogen Receptor/ERR (2)

Glucocorticoid Receptor (2)

GPR (2)

GTPase (2)

Hck (2)

HER (2)

Histamine Receptor (2)

IFNAR (2)

IRAK (2)

KLF (2)

Leukotriene Receptor (2)

MELK (2)

Microtubule Associated (2)

MRP (2)

NADPH (2)

NEDD8 (2)

Opioid Receptor (2)

PD-1/PD-L1 (2)

PGE Synthase (2)

Prostaglandin Receptor (2)

RAAS (2)

Reverse Transcriptase (2)

S1P Receptor (2)

Serine/threonin kinase (2)

TAM Receptor (2)

Transferase (2)

transporter (2)

5-HT Receptor (1)

Adenosine deaminase (1)

Amino Acids and Derivatives (1)

Androgen Receptor (1)

Annexin A (1)

Antifection (1)

Anti-infection (1)

ATP Citrate Lyase (1)

ATPase (1)

BCRP (1)

cAMP (1)

CCR (1)

cell cycle arrest (1)

CFTR (1)

c-Myc (1)

CXCR (1)

DNA Alkylator/Crosslinker (1)

DNA Methyltransferase (1)

Ephrin Receptor (1)

FAAH (1)

Factor Xa (1)

Fatty Acid Synthase (1)

FLAP (1)

Free radical scavengers (1)

FXR (1)

Gap Junction Protein (1)

Glucagon Receptor (1)

GluR (1)

GPX (1)

Guanylate cyclase (1)

Histone Acetyltransferase (1)

Hydroxylase (1)

iGluR (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Kinesin (1)

Lipase (1)

Liver X Receptor (1)

LPL Receptor (1)

LTR (1)

MAO (1)

Monoamine Oxidase (1)

Myosin (1)

Na+/Ca2+ Exchanger (1)

NADPH-oxidase (1)

Neprilysin (1)

PAD (1)

PAI-1 (1)

PAK (1)

Pim (1)

PKM (1)

Progesterone Receptor (1)

Protease-activated Receptor (1)

PYK2 (1)

Pyroptosis (1)

Retinoid Receptor (1)

RSV (1)

STING (1)

Thioredoxin (1)

Tie-2 (1)

YAP (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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