目录号 | 产品详情 | 靶点 | |
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T6150 | p38 MAPK Casein Kinase JNK | ||
TAK-715 是一种具有口服活性的p38 MAPK 抑制剂,对 p38α 和 p38β 的IC50分别为 7.1 nM 和200 nM。它抑制酪蛋白激酶 I (CK1δ/ε),调节 Wnt/β-catenin 信号传导的激活,有抗炎活性。 | |||
T78730 | |||
TNF-α-IN-11 (Compound 10)是一种TNF-α抑制剂, KD值为12.06 μM。该化合物通过结合TNF-α并阻断其诱发的caspase和NF-κB信号通路激活,来实现其抑制作用。其具体机制包括抑制IκBα磷酸化和NF κB p65的核转位,适用于研究TNF-α介导的自身免疫性疾病。 | |||
T4328 | HBV Sirtuin | ||
OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂,对 SIRT6,SIRT1 和 SIRT2 的 IC50分别为 89 μM,1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性,可抑制 HBV 的转录和复制。 | |||
T4S1521 | HIV Protease | ||
1,4-Dicaffeoylquinic acid 是一种苯丙素类物质,从苍耳子中获得,可以减少 LPS 诱导的 TNF-α 的生成,具有抗炎活性。 | |||
T13324 | CXCR Arrestin | ||
VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体,pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化,pEC50分别为 8.8 和 7.9。 | |||
T76026 | |||
TNF-α (31-45), human TFA 是人肿瘤坏死因子-α 的多肽片段。TNF α 是一种炎性细胞因子,可诱导坏死或凋亡。 | |||
T9028 | STING | ||
STING-IN-2 (C-170) 是一种 STING 共价抑制剂,可抑制小鼠 STING (mmSTING) 和人类 STING (hsSTING),可用于自身炎症性疾病的研究。 | |||
T1813 | IL Receptor TNF Interleukin | ||
VGX-1027 (GIT 27) 是一种口服有效的异恶唑化合物,靶向巨噬细胞,减少促炎性介质 TNF-α、IL-1β和 IL-10 的产生,具有免疫调节特性。它通过限制细胞因子介导的免疫炎症而具有抗糖尿病作用。 | |||
T3185 | Syk | ||
R112 ((E)-Elafibranor) 是ATP 竞争性的 Syk 激酶抑制剂,它能够抑制Syk 激酶活性,Ki=6 nM,IC50=226 nM。 | |||
T6204 | TNF NF-κB | ||
QNZ (EVP4593) 是 NF-κB 活化和 TNF-α 产生的一种有效抑制剂。 QNZ 对 NF-κB 和 TNF-α 的 IC50 分别为 11 nM 和 7 nM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00779 | TNF alpha Protein, Rabbit, Recombinant | Rabbit | E. coli | ||
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells.
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TMPY-01294 | TNF alpha Protein, Mouse, Recombinant | Mouse | E. coli | ||
TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.
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TMPY-04146 | TNF alpha Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
TNF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and the accession number is P01375.
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TMPY-00936 | TNF alpha Protein, Human, Recombinant | Human | E. coli | ||
TNF alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
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TMPY-02202 | TNF alpha Protein, Rat, Recombinant | Rat | E. coli | ||
TNF alpha Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P16599.
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TMPY-02153 | TNF beta Protein, Human, Recombinant | Human | E. coli | ||
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.
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TMPY-02535 | TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.4 kDa and the accession number is P25118.
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TMPJ-00288 | TNF RII Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333.
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TMPY-01697 | TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119.
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TMPK-00583 | TNF alpha Protein, Ferret, Recombinant (His) | Ferret | E. coli | ||
TNF alpha Protein, Ferret, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.88 kDa and the accession number is A3FBF1.
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TMPY-03203 | CD40 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CD40 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.6 kDa and the accession number is A0A8I6A2T5.
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TMPK-00119 | TNF alpha Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.35 kDa and the accession number is P79337.
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TMPJ-00287 | TNF RII Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333.
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TMPY-05187 | TNF alpha Protein, Mouse, Recombinant, Biotinylated | Mouse | E. coli | ||
TNF alpha Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P06804.
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TMPK-00120 | TNF alpha Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
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TMPY-01166 | TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P20333-1.
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TMPJ-00124 | TNF alpha Protein, Human, Recombinant (aa 77-233, His) | Human | E. coli | ||
TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 16 KDa and the accession number is P01375.
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TMPY-05237 | TNF alpha Protein, Human, Recombinant, Biotinylated | Human | E. coli | ||
TNF alpha Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375.
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TMPK-00121 | TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
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TMPJ-00125 | TNF alpha Protein, Human, Recombinant (aa 57-233, His) | Human | E. coli | ||
TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P01375.
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TMPY-01459 | TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1.
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TMPY-02069 | TNF alpha Protein, Cynomolgus, Rhesus, Recombinant | Cynomolgus,Rhesus | E. coli | ||
TNF alpha Protein, Cynomolgus, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is NP_001040614.1.
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TMPY-05516 | TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated | Cynomolgus | E. coli | ||
TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P79337.
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TMPY-01594 | TNF alpha Protein, Canine, Recombinant | Canine | E. coli | ||
TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0.
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TMPY-02226 | TNF alpha Protein, Ferret, Recombinant | Ferret | E. coli | ||
TNF alpha Protein, Ferret, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A3FBF1.
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TMPY-01181 | CD40 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD40 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is A0A0S2Z3C7.
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TMPJ-00137 | APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells | ||
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA. APRIL can form bioactive heterotrimers with BAFF, and these circulate in the serum of patients with rheumatic immune disorders. APRIL enhances the proliferation and survival of plasma cells and also promotes T cell-dependent humoral responses. APRIL levels are elevated in the serum during coronary artery disease, and it is also elevated in many cancers primarily due to expression by tumor-infiltratin neutrophils.
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TMPJ-01391 | BAFF/TNFSF13B Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 Cells | ||
BAFF/TNFSF13B Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 45-60 KDa and the accession number is Q9WU72.
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TMPJ-00603 | TL1A/TNFSF15 Protein, Mouse, Recombinant | Mouse | E. coli | ||
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
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TMPY-05957 | CD40 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
CD40 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.81 kDa and the accession number is P27512-1.
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TMPY-01639 | TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is P25118.
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TMPY-01696 | TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is P25119.
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TMPJ-00280 | TNF R1 Protein, Mouse, Recombinant | Mouse | E. coli | ||
Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome
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TMPH-02770 | TNF beta Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. TNF beta Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P09225.
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TMPK-01382 | TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
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TMPK-00564 | TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.
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TMPY-05039 | LTBR Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
LTBR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is P36941-1.
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TMPJ-00607 | RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
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TMPH-03745 | TNF-alpha Protein, Zebrafish, Recombinant (His) | Danio rerio (Zebrafish) | E. coli | ||
TNF-alpha Protein, Zebrafish, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q08CQ3.
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TMPY-03212 | CD40 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
CD40 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is F6SNI1.
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TMPY-00248 | Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Baculovirus Insect Cells | ||
LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. Heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherichia coli (ETEC) is both a strong mucosal adjuvant and immunogen. It is a subunit vaccine candidate to be used against ETEC-induced diarrhea. It has already been expressed in several bacterial and plant systems.LTB provokes a systemic immune response and exerts adjuvant effects on mucosal immune responses to unrelated antigens. Diseases associated with LTB include Synovitis and Myasthenic Syndrome, Congenital, 2C, Associated With Acetylcholine Receptor Deficiency.
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TMPY-03211 | CD40 Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells | ||
CD40 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is F6SNI1.
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TMPY-03944 | CD40 Protein, Canine, Recombinant | Canine | HEK293 Cells | ||
CD40 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.9 kDa and the accession number is Q7YRL5.
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TMPY-03907 | CD40 Protein, Canine, Recombinant (hFc) | Canine | HEK293 Cells | ||
CD40 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.1 kDa and the accession number is Q7YRL5.
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TMPY-03083 | CD40 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
CD40 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q4QQW2.
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TMPY-04089 | CD40 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells | ||
CD40 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q7YRL5.
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TMPY-06600 | TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
TNFR2/CD120b/TNFR1B Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.39 kDa and the accession number is NP_001057.1.
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TMPH-01620 | TNF beta Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
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TMPY-05475 | TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48 kDa and the accession number is P19438-1.
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TMPJ-00619 | TNF RII Protein, Rhesus macaque, Recombinant (His) | Rhesus | HEK293 Cells | ||
TNF RII Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-45 KDa and the accession number is F7EAF8.
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