目录号 | 产品详情 | 靶点 | |
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T0816 | Potassium Channel NADPH | ||
Acetohexamide (Acetohexamid) 是磺脲类试剂,可刺激胰腺分泌胰岛素,能够用于 2 型糖尿病的相关研究。 | |||
T21890 | Gamma-secretase | ||
JLK-6 是一种γ分泌酶抑制剂,选择性作用于 HEK293细胞的淀粉样β前体蛋白(APP)的γ-分泌酶裂解 APP,抑制 Aβ的生成,但对不 Notch 受体的裂解无影响。 | |||
T4532 | IDO Indoleamine 2,3-Dioxygenase (IDO) | ||
Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂,能够有效抑制 IDO1-HEK293 细胞,其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。 | |||
T13423 | Others | ||
(1R,2R)-2-PCCA hydrochloride 是一种具有有效性、选择性和可穿过血脑屏障的 GPR88 受体激动剂,在 WT 小鼠纹状体膜中 EC50 值为1140 n。(1R,2R)-2-PCCA hydrochloride 可用于研究中枢神经系统。 | |||
T8445 | Apoptosis 5-HT Receptor | ||
PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) 是5-HT3受体的负变构调节剂,是 6-MP 的一个衍生物。它在 HEK293 细胞测得的转染 5-HT3A 和 5-HT3AB 受体后的 IC50值分别为 0.36 和 0.73 μM。 | |||
T6891 | Apoptosis Hedgehog/Smoothened Smo | ||
MK-4101 是一种 SMO 拮抗剂 ,对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂 ,对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤,抑制肿瘤细胞增殖并诱导细胞凋亡。 | |||
T38361 | IL Receptor NOD | ||
GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导,抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。 | |||
T11108 | TLR | ||
DSR-6434仅在表达hTLR7的HEK293细胞中刺激TLR7活性,而在表达相似结构的hTLR8或hTLR9的HEK2 93细胞中不产生刺激效果。DSR-6434与特异性受体的结合会导致NF-κb 活化。 | |||
T3478 | GluR | ||
Ro 67-7476 是mGluR1的正变位调节剂,能增强表达 rat mGluR1a 的 HEK293 细胞中谷氨酸诱导的钙释放,EC50为 60.1 nM。它是 P-ERK1/2 激动剂,可以在外源添加谷氨酸的情况下激活 ERK1/2 磷酸化 (EC50=163.3 nM)。 | |||
T21623 | GPR TRP/TRPV Channel | ||
AS1269574 是口服有效的GPR119激动剂,在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道,刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02792 | GDNF Protein, Human, Recombinant (HEK293) | Human | HEK293 Cells | ||
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
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TMPY-06985 | NGF Protein, Human, Recombinant (HEK293) | Human | HEK293 Cells | ||
NGF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.8 kDa. and the accession number is P01138.
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TMPY-01920 | BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) | Human | HEK293 Cells | ||
BAFF/TNFSF13B Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9Y275-1.
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TMPY-01191 | CD3 epsilon/CD3e Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
CD3 epsilon/CD3e Protein, Human, Recombinant (HEK293,His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.2 kDa and the accession number is P07766.
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TMPY-04090 | Influenza A H7N9 (A/Shanghai/2/2013) Hemagglutinin/HA Protein (HEK293, His) | H7N9 | HEK293 Cells | ||
Influenza A H7N9 (A/Shanghai/2/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa.
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TMPY-01501 | Influenza A H1N1 (A/Puerto Rico/8/1934) Hemagglutinin/HA Protein (HEK293, His) | H1N1 | HEK293 Cells | ||
Influenza A H1N1 (A/Puerto Rico/8/1934) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is P03452.
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TMPH-01683 | Tau Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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TMPJ-00895 | SCF Protein, Rat, Recombinant (HEK293, His) | Rat | HEK293 Cells | ||
SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.
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TMPY-02024 | L-selectin Protein, Human, Recombinant (HEK293,His) | Human | HEK293 Cells | ||
L-selectin Protein, Human, Recombinant (HEK293,His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.5 kDa and the accession number is P14151-1.
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TMPH-00343 | Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) | Canine | HEK293 Cells | ||
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q60FC1.
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TMPJ-01022 | SUMO3 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collectively called SUMO2/3. Several studies suggest that SUMO3 are associated with pathogenesis in several neurological diseases, including Alzheimer's disease, Parkinson's disease, and cerebral ischemia/stroke.
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TMPY-06314 | MMP-10 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
MMP-10 Protein, Human, Recombinant (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.38 kDa and the accession number is P09238.
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TMPJ-01163 | CTGF/CCN2 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF has various biological functions, including cell adhesion, migration, proliferation, differentiation, and ECM production, and participates in the development of many organs under normal physiologic conditions. CTGF is pathologically viewed as a central mediator of tissue remodeling and fibrosis of various organs, including the lung, heart, liver, and kidney.
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TMPH-00743 | PhoP Protein, E. coli, Recombinant (HEK293, His & Myc) | E. coli | HEK293 Cells | ||
Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes.
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TMPY-02167 | Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) | Mouse | HEK293 Cells | ||
Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P03953-2.
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TMPJ-00716 | Cerberus 1/CER1 Protein, Human, Recombinant (HEK293, His) | Human | HEK293 Cells | ||
Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.
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TMPY-05683 | SARS-CoV-2 Spike RBD Protein (HEK293, His), Biotinylated | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (HEK293, His), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.54 kDa and the accession number is A0A6G7K2L4.
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TMPJ-00386 | ACE2/ACEH Protein, Human, Recombinant (HEK293, His & Avi), Biotinylated | Human | HEK293 Cells | ||
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
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TMPY-05661 | SARS-CoV-2 Spike S1 Protein (HEK293, His) | HEK293 Cells | |||
SARS-CoV-2 Spike S1 Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The accession number is A0A6G7K2L4.
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TMPY-05719 | SARS-CoV-2 Spike RBD Protein (HEK293, Avi & His), Biotinylated | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (HEK293, Avi & His), Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 28.36 kDa and the accession number is A0A6G7K2L4.
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TMPY-03800 | Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin/HA Protein (HEK293, His) | H7N9 | HEK293 Cells | ||
Influenza A H7N9 (A/Shanghai/1/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa.
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TMPY-05932 | Influenza A H1N1 (A/swine/Canada/01093/2006) Neuraminidase/NA Protein (HEK293, His) | H1N1 | HEK293 Cells | ||
Influenza A H1N1 (A/swine/Canada/01093/2006) Neuraminidase/NA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.2 kDa and the accession number is A0A0G3XQY1.
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TMPY-03840 | Influenza A H7N9 (A/Pigeon/Shanghai/S1069/2013) Hemagglutinin/HA Protein (HEK293, His) | H7N9 | HEK293 Cells | ||
Influenza A H7N9 (A/Pigeon/Shanghai/S1069/2013) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa.
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TMPY-00549 | Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His) | H5N1 | HEK293 Cells | ||
Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is B7NWR4.
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TMPY-00595 | Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His) | H5N1 | HEK293 Cells | ||
Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is B7NWR4.
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TMPY-06987 | Wnt Surrogate/Wnt3a Protein, Recombinant | Human | HEK293 Cells | ||
Wnt Surrogate/Wnt3a Protein, Recombinant is expressed in HEK293 mammalian cells with hFc tag.
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TMPY-05573 | CD38 Protein, Human, Recombinant (His), PE conjugated | Human | HEK293 Cells | ||
CD38 Protein, Human, Recombinant (His), PE conjugated is expressed in HEK293 mammalian cells with His tag. The accession number is NP_001766.2.
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TMPY-04845 | IL-3 Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
IL-3 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.7 kDa and the accession number is P01586.
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TMPY-00167 | HER2/ERBB2 Protein, Human, Recombinant | Human | HEK293 Cells | ||
HER2/ERBB2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 70 kDa and the accession number is P04626-1.
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TMPY-03481 | IL-1R2 Protein, Human, Recombinant | Human | HEK293 Cells | ||
IL-1R2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.4 kDa and the accession number is P27930-1.
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TMPY-00748 | Nectin-2 Protein, Human, Recombinant | Human | HEK293 Cells | ||
Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
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TMPY-03466 | PLGF/PGF Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
PLGF/PGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16.6 kDa and the accession number is P49764.
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TMPY-00443 | EPO/Erythropoietin Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
EPO/Erythropoietin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.6 kDa and the accession number is P07321.
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TMPY-01919 | MMP-9 Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
MMP-9 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 78.4 kDa and the accession number is P41245-1.
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TMPY-03467 | IFN-beta Protein, Mouse, Recombinant | Mouse | HEK293 Cells | ||
IFN-beta Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.3 kDa and the accession number is P01575.
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TMPY-05202 | Noggin/NOG Protein, Human, Recombinant | Human | HEK293 Cells | ||
Noggin/NOG Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.1 kDa and the accession number is Q13253.
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TMPY-04829 | G-CSF Protein, Human, Recombinant | Human | HEK293 Cells | ||
G-CSF Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18.7 kDa and the accession number is P09919-2.
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TMPY-05072 | IgE Fc Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IgE Fc Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.4 kDa.
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TMPY-00608 | TGF beta 1 Protein, Rat/Mouse, Recombinant | Mouse,Rat | HEK293 Cells | ||
TGF beta 1 Protein, Rat/Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa.
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TMPY-03357 | FGFR2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
FGFR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is AAA39377.1.
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TMPY-05679 | SARS-CoV-2 Spike RBD Protein (hFc) | SARS-CoV-2 | HEK293 Cells | ||
SARS-CoV-2 Spike RBD Protein (hFc) is expressed in HEK293 mammalian cells. The predicted molecular weight is 51.8 kDa and the accession number is A0A6G7K2L4.
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TMPY-01008 | VEGFD Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915.
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TMPY-05047 | CD44 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
CD44 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.6 kDa and the accession number is Q3U8S1.
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TMPY-00463 | ENPP2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
ENPP2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is XP_005564040.1.
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TMPY-04925 | CD8 beta Protein, Human, Recombinant, Biotinylated | Human | HEK293 Cells | ||
CD8 beta Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is P10966-1.
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TMPY-05476 | MICA Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
MICA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.3 kDa and the accession number is A9UJR3.
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TMPY-00989 | LDLR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
LDLR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5.
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TMPY-03377 | CD73 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CD73 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is EHH53214.1.
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TMPY-00850 | ST2/IL-1 RL1 Protein, Human, Recombinant | Human | HEK293 Cells | ||
ST2/IL-1 RL1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.6 kDa and the accession number is Q01638-2.
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TMPY-00876 | Legumain Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Legumain Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.8 kDa and the accession number is A2RTI3.
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