目录号 | 产品详情 | 靶点 | |
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T38381 | |||
CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620, and DLD-1 colorectal cancer cells (IC50s = 0.45, 1.78, and 2.11 μM, respectively), as well as induces apoptosis and autophagy in HCT116 cells. It reduces tumor growth in an HCT116 mouse xenograft model when administered at doses of 15 and 30 mg/kg. 1.Pan, Z., Li, X., Wang, Y., et al.Discovery of thieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as bromodomain-containing protein 4/histone deacetylase dual inhibitors induce autophagic cell death in colorectal carcinoma cellsJ. Med. Chem.63(7)3678-3700(2020) | |||
T37861 | |||
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9, activates the proprotein form of caspase-1 independent of the inflammasome adaptor ASC[2]. Talabostat competitively inhibits the dipeptidyl peptidase (DPP) activity of FAP and CD26/DPP-IV, and there is a high-affinity interaction with the catalytic site due to the formation of a complex between Ser630/624 and the boron of talabostat[3]. Talabostat can stimulate immune responses against tumors involving both the innate and adaptive branches of the immune system. In WEHI 164 fibrosarcoma and EL4 and A20/2J lymphoma models, PT-100 causes regression and rejection of tumors. The antitumor effect appears to involve tumor-specific CTL and protective immunological memory. Talabostat treatment of WEHI 164-inoculated mice increases mRNA expression of cytokines and chemokines known to promote T-cell priming and chemoattraction of T cells and innate effector cells[3]. Talabostat treated mice show significant less fibrosis and FAP expression is reduced. Upon PT100 treatment, significant differences in the MMP-12, MIP-1α, and MCP-3 mRNA expression levels in the lungs are also observed. Treatment with PT100 in this murine model of pulmonary fibrosis has an anti-fibro-proliferative effect and increases macrophage activation[4]. [1]. Connolly BA, et al. Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potencyand in vivo efficacy and safety. J Med Chem. 2008 Oct 9;51(19):6005-13. [2]. Okondo MC, et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017 Jan;13(1):46-53. [3]. Adams S, et al. PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res. 2004 Aug 1;64(15):5471-80. [4]. Egger C, et al. Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis. Eur J Pharmacol. 2017 Aug 15;809:64-72. | |||
T35560 | |||
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mice expressing P301L tau[2].SAR502250 (10-30 mg/kg; p.o. once daily for 7 weeks) improves the cognitive deficit in transgenic APP(SW)/Tau(VLW) mice after infusion of Aβ25-35[2].SAR502250 (10-30 mg/kg; a single p.o.) significantly increases the percentage of lever-presses in the inter-response time (IRT) bin (49-96 s), with a significant augmentation of the percentage of reinforced responses[2].SAR502250 (30 mg/kg; i.p. once daily for 28 d) ameliorates chronic stress-induced degradation of the physical state of the mice coat[2].SAR502250 (10-60 mg/kg; a single p.o.) decreases hyperactivity produced by psychostimulantsin mice[2]. [1]. Fukunaga K, et, al. 2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6933-7.[2]. Griebel G, et, al. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer’s disease in rodents. Sci Rep. 2019 Dec 2;9(1):18045. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-05815 | PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated | Canine | HEK293 Cells | ||
PD-1 Protein, Canine, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 19.41 kDa and the accession number is A0A090BAM7.
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TMPY-04342 | PD-1 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells | ||
PD-1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is XP_022265285.1.
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TMPY-05260 | PD-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
PD-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is B0LAJ3.
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TMPY-05395 | PD-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
PD-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q02242.
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TMPY-00996 | PD-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
PD-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.6 kDa and the accession number is Q02242.
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TMPY-04898 | PD-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
PD-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is A0A0M3M0G7.
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TMPY-05079 | PD-1 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
PD-1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.3 kDa and the accession number is A0A0M3M0G7.
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TMPY-00897 | PD-1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
PD-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is A0A0M3M0G7.
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TMPY-04957 | PD-L2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
PD-L2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1.
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TMPY-05827 | PD-L2 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
PD-L2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 48.93 kDa and the accession number is Q9BQ51-1.
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TMPY-04346 | PD-L2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
PD-L2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1.
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TMPY-00253 | PD-1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
PD-1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is B0LAJ3.
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TMPJ-01059 | CRADD Protein, Human, Recombinant | Human | E. coli | ||
Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues, with particularly high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2, and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numerous tissues. Defects in CRADD will result in mental retardation.
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TMPY-00633 | PD-1 Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells | ||
PD-1 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession number is A0A8J8XRF6.
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TMPY-00250 | PD-1 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
PD-1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is A0A8J8XRF6.
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TMPY-03717 | PD-1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
PD-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.2 kDa and the accession number is A6JR44.
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TMPY-00233 | PD-1 Protein, Canine, Recombinant (hFc) | Canine | HEK293 Cells | ||
PD-1 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession number is XP_543338.3.
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TMPY-00047 | Dengue virus DENV-2 (Strain New Guinea C) Capsid protein/DENV-C Protein (His) | DENV | E. coli | ||
Dengue virus DENV-2 (Strain New Guinea C) Capsid protein/DENV-C Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14 kDa and the accession number is W0GCK5.
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TMPY-04341 | PD-1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
PD-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is A6JR44.
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TMPY-05295 | PD-1 Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated | Cynomolgus | HEK293 Cells | ||
PD-1 Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 44.5 kDa and the accession number is B0LAJ3.
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TMPY-04223 | PD-L2 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
PD-L2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.2 kDa and the accession number is D4AAV6.
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TMPY-03738 | PD-L2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
PD-L2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is A4GW30.
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TMPY-03834 | Fas/CD95 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
Fas/CD95 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.8 kDa and the accession number is F6V1W6.
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TMPY-04282 | Fas/CD95 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
Fas/CD95 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.7 kDa and the accession number is A6I127.
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TMPJ-00137 | APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells | ||
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA. APRIL can form bioactive heterotrimers with BAFF, and these circulate in the serum of patients with rheumatic immune disorders. APRIL enhances the proliferation and survival of plasma cells and also promotes T cell-dependent humoral responses. APRIL levels are elevated in the serum during coronary artery disease, and it is also elevated in many cancers primarily due to expression by tumor-infiltratin neutrophils.
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TMPY-00632 | Fas/CD95 Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
Fas/CD95 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is F6V1W6.
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TMPY-02057 | Fas/CD95 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
Fas/CD95 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is A6I127.
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TMPY-03404 | PD-L2 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
PD-L2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.6 kDa and the accession number is A4GW30.
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TMPY-06819 | PD-L2 Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells | ||
PD-L2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.6 kDa and the accession number is A4GW30.
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TMPY-02027 | BID Protein, Human, Recombinant | Human | E. coli | ||
BID Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22 kDa and the accession number is P55957-1.
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TMPY-04225 | PD-L2 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
PD-L2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.9 kDa and the accession number is D4AAV6.
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TMPY-06838 | PD-L2 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
PD-L2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is NP_001077068.1.
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TMPY-04967 | PD-1 Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells | ||
PD-1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.6 kDa and the accession number is Q02242.
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TMPY-04417 | DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) | Human | Baculovirus Insect Cells | ||
Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 gene has been found in many carcinomas. DAPK1 over-expression can induce cell apoptosis and inhibit tumor cell metastasis. DAPK1 gene over-expression could suppress PGCl3 cells malignant phenotype, inhibit PGCl3 cells growth, invasive, migration and adhesion ability, upregulate p53 gene and downregulate bcl-2 gene. Loss of activity of death-associated protein kinase 1 ( DAPK1 ) may be an independent factor affecting survival of non-small cell lung cancer patients. DAPK1 promoter methylation might play a significant role in the progression of chronic myeloid leukemia ( CML ).
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TMPY-04385 | ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. It also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. DAPK3 / ZIPK regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It is involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
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TMPY-02065 | BID Protein, Mouse, Recombinant (His & GST) | Mouse | E. coli | ||
BID Protein, Mouse, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 50 kDa and the accession number is EDK99650.1.
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TMPY-03317 | DcR2/TRAIL R4 Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells | ||
DcR2/TRAIL R4 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is XP_001107922.1.
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TMPJ-00181 | PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
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TMPJ-00183 | PD-L1 Protein, Human, Recombinant (Flag) | Human | HEK293 Cells | ||
PD-L1 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 35-40 KDa and the accession number is Q9NZQ7.
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TMPY-05282 | PD-L2 Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells | ||
PD-L2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9WUL5.
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TMPY-02213 | RAIDD Protein, Human, Recombinant (His) | Human | E. coli | ||
Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the interaction with caspase-2. FADD / MORT1 is a death domain (DD)-containing adaptor / signaling molecule that interacts with the intracellular DD of FAS / APO-I ( CD95 ) and tumor necrosis factor receptor 1 and the prodomain of caspase-8 ( Mch5 / MACH / FLICE). CRADD / RAIDD has a dual-domain structure similar to that of FADD. CRADD / RAIDD has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. CRADD / RAIDD could play a role in regulating apoptosis in mammalian cells. CRADD / RAIDD is a apoptotic adaptor molecule specific for caspase-2 and FASL / TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD / RAIDD recruits caspase-2 to the TNFR-1 signalling complex.
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TMPJ-00182 | PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells | ||
PD-L1 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 70-95 KDa and the accession number is Q9NZQ7.
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TMPY-03318 | DcR2/TRAIL R4 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
DcR2/TRAIL R4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is XP_001107922.1.
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TMPY-02436 | PD-L2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
PD-L2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.5 kDa and the accession number is Q9WUL5.
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TMPY-02352 | PD-L2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
PD-L2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9WUL5.
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TMPY-06682 | PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His) | Human | HEK293 Cells | ||
PD-1 Protein, Human, Recombinant (Asp26-Pro39 deletion, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.65 kDa and the accession number is NP_005009.2.
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TMPY-05619 | PD-1 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
PD-1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is A0A0M3M0G7.
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TMPJ-00246 | TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
TRAIL R2/DR5/TNFRSF10B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-75 KDa and the accession number is Q9QZM4.
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TMPJ-00718 | AIF Protein, Human, Recombinant (His) | Human | E. coli | ||
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.
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TMPY-00799 | Fas/CD95 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Fas/CD95 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is P25445-1.
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