铁死亡化合物库 | 陶术生物

铁死亡化合物库

Ferroptosis Compound Library

产品编号： L8700

铁死亡（ferroptosis）是近年来发现的一种由铁依赖的氧化损伤引起的细胞死亡模式，与凋亡、坏死、自噬不同，铁死亡的特征主要是细胞体积缩小和线粒体膜密度增加，没有典型的细胞凋亡和坏死表现。ferroptosis 与神经系统疾病、肿瘤（特别是乳腺癌、弥漫性大 B 细胞淋巴瘤）、缺血再灌注损伤、肾损伤、动脉粥样硬化、糖尿病、心脏病等疾病有关，进一步深入研究铁死亡的作用机理，研究其在不同疾病类型中的作用，对寻找相关疾病的治疗靶点、靶向药物的研发具有重要意义。

TargetMol 铁死亡化合物库，收集了 800 种与铁死亡通路相关的化合物，靶点包括 GPX4、ROS、p53、Nrf2等，另外还包含了铁螯合剂、抗氧化剂等多种类型小分子，助力您铁死亡通路相关的靶点鉴定和药物研发。

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品描述

800种与铁死亡通路相关的化合物，可用于高通量和高内涵筛选；
靶点含GPX4,ROS,p53,Nrf2等；
部分化合物已被FDA批准上市；
详细的说明书，化合物结构、靶点信息、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库组成

Antioxidant (88)

ROS (39)

NF-κB (32)

p53 (24)

COX (22)

Endogenous Metabolite (20)

Raf (19)

Autophagy (16)

Nrf2 (15)

P450 (15)

PPAR (15)

TNF (15)

Apoptosis (14)

Mdm2 (13)

Calcium Channel (11)

Dehydrogenase (11)

DPP-4 (11)

Ferroptosis (11)

Lipoxygenase (11)

MEK (11)

Antibacterial (10)

STAT (10)

AChR (9)

DNA/RNA Synthesis (9)

ERK (9)

HMG-CoA Reductase (9)

MMP (9)

5-HT Receptor (8)

Antibiotic (8)

Estrogen/progestogen Receptor (8)

p38 MAPK (8)

Vitamin (8)

Dopamine Receptor (7)

HIF (7)

Histamine Receptor (7)

IL Receptor (7)

PKC (7)

Tyrosinase (7)

Akt (6)

AMPK (6)

BCL (6)

CDK (6)

EGFR (6)

Glucokinase (6)

Ras (6)

Sirtuin (6)

VEGFR (6)

IκB/IKK (5)

MAO (5)

NADPH (5)

NOS (5)

Rho (5)

Adrenergic Receptor (4)

ATPase (4)

BACE (4)

Beta Amyloid (4)

Caspase (4)

GABA Receptor (4)

HIV Protease (4)

JNK (4)

PDGFR (4)

PI3K (4)

RAAS (4)

Src (4)

Trk receptor (4)

AhR (3)

ALK (3)

Antifection (3)

Aurora Kinase (3)

Carbonic Anhydrase (3)

Epigenetic Reader Domain (3)

Free radical scavengers (3)

GPX (3)

MAPK (3)

NADPH-oxidase (3)

Parasite (3)

PARP (3)

Potassium Channel (3)

Reductase (3)

Reverse Transcriptase (3)

TGF-beta/Smad (3)

Wnt/beta-catenin (3)

Amino Acids and Derivatives (2)

Antifungal (2)

Antiviral (2)

Aromatase (2)

CaMK (2)

cell cycle arrest (2)

c-Kit (2)

Cysteine Protease (2)

DNA Alkylation (2)

FGFR (2)

FLT (2)

Glucocorticoid Receptor (2)

GluR (2)

GSK-3 (2)

GTPase (2)

HDAC (2)

HSP (2)

HSV (2)

Influenza Virus (2)

Mitochondrial Metabolism (2)

mTOR (2)

NMDAR (2)

NOD (2)

Opioid Receptor (2)

PDE (2)

Phospholipase (2)

PKA (2)

PKM (2)

Prostaglandin Receptor (2)

Proteasome (2)

ribosome (2)

S6 Kinase (2)

Serine Protease (2)

SGLT (2)

Sodium Channel (2)

TLR (2)

TRP/TRPV Channel (2)

UGT (2)

advanced glycation end products (1)

Androgen Receptor (1)

Annexin A (1)

ASK (1)

ATM/ATR (1)

BMI-1 (1)

cAMP (1)

Casein Kinase (1)

c-Fms (1)

CFTR (1)

Chloride channel (1)

c-Met/HGFR (1)

c-RET (1)

CXCR (1)

DNA gyrase (1)

DUB (1)

E1/E2/E3 Enzyme (1)

FXR (1)

Gamma-secretase (1)

Glutathione reductase (1)

GST (1)

HCV Protease (1)

Hedgehog/Smoothened (1)

Hexokinase (1)

HIF/HIF Prolyl-Hydroxylase (1)

Hydrogenase (1)

Hydroxylase (1)

IAP (1)

Immunology & Inflammation related (1)

Integrin (1)

IRAK (1)

Keap1-Nrf (1)

LDL (1)

Lipid (1)

Liver X Receptor (1)

LRRK2 (1)

lysosomal autophagy (1)

Melatonin Receptor (1)

Microtubule Associated (1)

Mitophagy (1)

MPO (1)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

NPC1L1 (1)

P2X Receptor (1)

P-gp (1)

PLK (1)

Proton pump (1)

Reactive Oxygen Species (1)

Retinoid Receptor (1)

ROR (1)

SARS-CoV (1)

Sigma receptor (1)

Somatostatin (1)

stilbene oxidase (1)

Syk (1)

Telomerase (1)

Thioredoxin (1)

Thyroid hormone receptor(THR) (1)

Topoisomerase (1)

Transferase (1)

transporter (1)

Tyrosine Kinases (1)

Wnk (1)

Xanthine Oxidase (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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