PD-L1 Protein, Human, Recombinant (Flag)

CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

规格	价格/CNY		数量
10 μg	￥ 500	5日内发货
50 μg	￥ 1,170	5日内发货
500 μg	￥ 8,860	5日内发货
1 mg	￥ 12,600	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 500

5日内发货

50 μg

￥ 1,170

5日内发货

500 μg

￥ 8,860

5日内发货

1 mg

￥ 12,600

5日内发货

生物活性

1. Loaded Human PD-1-Fc on Protein A Biosensor, can bind Human PD-L1-Flag with an affinity constant of 0.19 uM as determined in BLI assay. (Regularly tested) 2. Immobilized Human PD-L1-Flag at 2μg/ml (100 μl/well)can bind Anti-Human PDL1 mAb-Fc. The ED50 of Anti-Human PDL1 mAb-Fc is 14.68 ng/ml. (Regularly tested)

产品描述

种属	Human
表达系统	Human Cells
标签	C-Flag
蛋白编号	Q9NZQ7
别名	B7-H1, Programmed Cell Death 1 Ligand 1, PD-L1, PDCD1L1, B7 Homolog 1, PDCD1LG1, PDL1, B7H1, CD274, PDCD1 Ligand 1, Programmed Death Ligand 1
氨基酸序列	Phe19-Thr239
蛋白构建	Recombinant Human Programmed Cell Death 1 Ligand 1 is produced by our Mammalian expression system and the target gene encoding Phe19-Thr239 is expressed with a Flag tag at the C-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	35-40 KDa, reducing conditions

内毒素	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

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PD-L1 Protein, Human, Recombinant (Flag)

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