目录号 | 产品详情 | 靶点 | |
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T0433 | Virus Protease Ferroptosis STAT Parasite | ||
Artesunate (WR-256283) 是治疗疟疾的青蒿素组药物的一部分。 它是青蒿素的半合成衍生物,具有水溶性。 | |||
T4S1519 | Others | ||
Pseudoginsenoside RT5 分离于 Panax quinquefolium 中。它通过促进神经生长和提高认知能力,具有抗癫痫、抗抑郁活性,还具有抗菌、抗肿瘤、抗疟疾等活性。 | |||
T0860L | Others | ||
Mefloquine (Ro 215998) 是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂,IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。 | |||
T4382 | Others Dehydrogenase DNA/RNA Synthesis Antifolate Parasite | ||
Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 | |||
TN7082 | Others | ||
demethyldaphnoretin-7-O-glucoside 是从 Daphne oleoides Schreber subsp. 中分离出来的天然产物。在土耳其传统医学中,它的地上部分已被用于治疗疟疾、风湿病和伤口愈合。 | |||
T20754 | Others | ||
Deltamethrin (RU 22974) 是一种具有神经毒性的拟除虫菊酯杀虫剂,在大鼠中能够产生一系列可逆的运动症状(如包括后肢僵硬、舞蹈性关节炎)。 | |||
T70692 | HIV Protease | ||
ST7612AA1 是一种新型有效且可口服的 HDAC 抑制剂,作为作为HIV-1潜伏期再激活剂。ST7612AA1 在体内外实验中低浓度显示出显著的抗肿瘤活性。ST7612AA1 具有潜在的抗癌活性,可用于研究疟疾。 | |||
T9287 | SARS-CoV TLR Parasite Autophagy | ||
Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) 是一种合成抗疟疾剂,有效抑制SARS-CoV-2感染,也抑制 Toll 样受体 7/9 信号传导。 | |||
TN7225 | Antioxidant Parasite | ||
2'-Hydroxy-3,4-dimethoxychalcone 是从槐树根分离除的查耳酮化合物,具有抗氧化活性,抑制了多诺瓦尼乳杆菌寄生虫 EC 的细胞内存活50值介于 0.39 和 0.41 μg/mL 之间,可用于研究糖尿病,治疗血吸虫病、疟疾和其它感染。 | |||
T9279 | Others | ||
Nerolidol acetate是一种具有抗癌、抗炎、抗菌和抗虫的活性的天然倍半萜。Nerolidol acetate可抑制寄生虫活动,抑制吸血虫病、线虫病以及疟疾等。Nerolidol acetate可保护细胞免受脂质、蛋白质和 DNA 的氧化损伤,对小鼠海马神经细胞具有保护作用。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04180 | PfLDH Protein, P. falciparum, Recombinant (His) | P. falciparum | E. coli | ||
Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR assays to detect <1 parasite/microL suggests that improvements of bound antibody sensor technology may greatly increase the sensitivity of malaria rapid diagnostic tests. The PfLDH test could be used to detect failures and, therefore, to assess anti-malarial efficacy.
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TMPY-04765 | PKLR Protein, Human, Recombinant (His) | Human | E. coli | ||
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variable severity. PKLR expression was increased in liver metastases as well as in primary colorectal tumors of patients with metastatic disease. PKLR protein variants may affect the frequency, and the intensity of malaria episodes induced by different Plasmodium parasites in humans living in areas of endemic malaria.
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TMPY-03399 | KLHL2 Protein, Human, Recombinant (GST) | Human | E. coli | ||
KLHL2 (Kelch Like Family Member 2) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. KLHL2 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is widely expressed in the brain, esophagus, and other tissues. KLHL2 gene has been proposed to participate in intracellular protein transportation. KLHL2 is expected to have molecular functions such as transporter activity, actin-binding, and protein binding. KLHL2 localizes in various compartments such as actin cytoskeleton, cytoplasm, membrane, and nucleus. It may also play a role in organizing the actin cytoskeleton of the brain cells. Diseases associated with KLHL2 include Mixed Malaria and Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2.
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TMPY-03985 | Adenosine Deaminase Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Adenosine Desaminase (ADA) deficiency, is a purine metabolic disorder that cause severe combined immunodeficiency (SCID) due to the accumulation of toxic metabolites that primarily affects development, differentiation and function of T and B lymphocytes. Adenosine deaminase is a polymorphic enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor activity. ADA activity might be considered as a useful diagnostic tool among the other markers in these diseases. Genetic variability of ADA activity may have, therefore, an important role in resistance to malaria. Adenosine Deaminase (ADA) deficiency is an autosomal recessive variant of severe combined immunodeficiency (SCID) caused by systemic accumulation of ADA substrates.
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