目录号 | 产品详情 | 靶点 | |
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T74696 | Parasite | ||
SpdSyn binder-1 是一种弱结合剂,结合在恶性疟原虫亚精胺合酶的活性位点,对疟疾有部分抑制作用,可用于研究疟疾。 | |||
T5916 | Others Parasite | ||
Fmoc-N-Me-Phe-OH (Fmoc-N-methyl-L-phenylalanine) 是一种疟原虫多肽抑制剂。 | |||
T27214 | Dehydrogenase | ||
DSM421 (DSM-421)是一种二氢酸脱氢酶抑制剂(DHODH),作为疟疾的潜在治疗选择处于临床前开发阶段,对恶性疟原虫和间日疟原虫的田间分离株均表现出活性。 | |||
T67694 | Parasite | ||
ZY-19489是一种具有抗疟作用的化合物, 是一种潜在的单剂量根治性恶性疟原虫和间日疟原虫疟疾的药物,已获得美国 FDA 的孤儿药认定。 | |||
T3266 | Others Parasite Autophagy | ||
Lumefantrine (dl-Benflumelol) 是一种抗疟药,用于治疗急性单纯性疟疾。与Artemether 联用,可提高疗效。 | |||
T0026 | Antibacterial Antibiotic Parasite Autophagy | ||
Sulfalene (SMP2) 是一种长效磺胺类抗生素,用于治疗慢性支气管炎、尿路感染和疟疾。 | |||
THS1455 | Ferroptosis Parasite | ||
DihydroarteMisinic acid (Dihydro-Artmisinic Acid) 是青蒿的天然产物,是青蒿素的主要直接前体,青蒿素是一种广泛用于治疗疟疾的药草。 | |||
TN1568 | |||
Deoxyartemisinin (2-deoxyartemisinin) 是一种口服有效的抗炎和抗溃疡化合物,可从青蒿素青蒿中分离得到。 | |||
TN1012L | Parasite | ||
Febrifugine dihydrochloride (Propyldazine hydrochloride) 是存在于常山的根和叶中的一种喹唑啉酮类生物碱,具有治疗疟疾、癌症、纤维化和炎症性疾病的活性。 | |||
T7195 | Potassium Channel Parasite | ||
GSK369796 Dihydrochloride (N-tert-butylisoquine) 是一种抗疟药,可抑制 hERG 钾离子通道复极化,IC50值为 7.5 μM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04180 | PfLDH Protein, P. falciparum, Recombinant (His) | P. falciparum | E. coli | ||
Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR assays to detect <1 parasite/microL suggests that improvements of bound antibody sensor technology may greatly increase the sensitivity of malaria rapid diagnostic tests. The PfLDH test could be used to detect failures and, therefore, to assess anti-malarial efficacy.
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TMPY-04765 | PKLR Protein, Human, Recombinant (His) | Human | E. coli | ||
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variable severity. PKLR expression was increased in liver metastases as well as in primary colorectal tumors of patients with metastatic disease. PKLR protein variants may affect the frequency, and the intensity of malaria episodes induced by different Plasmodium parasites in humans living in areas of endemic malaria.
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TMPY-03399 | KLHL2 Protein, Human, Recombinant (GST) | Human | E. coli | ||
KLHL2 (Kelch Like Family Member 2) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. KLHL2 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is widely expressed in the brain, esophagus, and other tissues. KLHL2 gene has been proposed to participate in intracellular protein transportation. KLHL2 is expected to have molecular functions such as transporter activity, actin-binding, and protein binding. KLHL2 localizes in various compartments such as actin cytoskeleton, cytoplasm, membrane, and nucleus. It may also play a role in organizing the actin cytoskeleton of the brain cells. Diseases associated with KLHL2 include Mixed Malaria and Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2.
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TMPY-03985 | Adenosine Deaminase Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Adenosine Desaminase (ADA) deficiency, is a purine metabolic disorder that cause severe combined immunodeficiency (SCID) due to the accumulation of toxic metabolites that primarily affects development, differentiation and function of T and B lymphocytes. Adenosine deaminase is a polymorphic enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor activity. ADA activity might be considered as a useful diagnostic tool among the other markers in these diseases. Genetic variability of ADA activity may have, therefore, an important role in resistance to malaria. Adenosine Deaminase (ADA) deficiency is an autosomal recessive variant of severe combined immunodeficiency (SCID) caused by systemic accumulation of ADA substrates.
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