目录号 | 产品详情 | 靶点 | |
---|---|---|---|
T39437 | Syk | ||
Cevidoplenib dimesylate 是一种脾酪氨酸激酶 (Syk) 抑制剂,具有抗炎和免疫调节特性。 | |||
T10625 | BTK | ||
IBT6A 是一种 Ibrutinib 的杂质。它可用于合成 IBT6A-Ibrutinib 二聚体和 IBT6A 加合物。Ibrutinib 是不可逆的选择性 Btk 抑制剂 (IC50:0.5 nM)。 | |||
T2467 | Apoptosis FLT Syk | ||
R406 free base (R406(free base)) 是一种具有口服活性的,ATP 竞争性的Syk/FLT3抑制剂,Ki 为 30 nM。它有效抑制 Syk 激酶活性,IC50为 41 nM,可减轻免疫复合物介导的炎症。它还抑制 Lyn 和 Lck,IC50分别为 63 nM 和 37 nM。 | |||
T14177 | Apoptosis Others Antifungal | ||
Alexidine dihydrochloride 对多种真菌病原体具有抗真菌和抗生物膜活性。它是一种抗癌剂,可靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶 PTPMT1,并导致线粒体凋亡。 | |||
TQ0242 | BTK | ||
Fenebrutinib (GDC-0853) 是一种选择性的、有效的、具有口服活性的、非共价的布鲁顿酪氨酸激酶抑制剂,对野生型 Btk,及突变型 C481S,C481R,T474I,T474M 的 Ki 分别为 0.91 nM,1.6,1.3,12.6 和 3.4 nM。有用于类风湿关节炎和系统性红斑狼疮研究的潜力。 | |||
T5407 | BTK | ||
Branebrutinib (BMS986195) 是一个高效的、不可逆的、共价的、选择抑的布鲁顿氏酪氨酸激酶(BTK)的制剂 (IC50:0.1 nM)。 | |||
T14323 | BTK | ||
ARQ 531 是一种可逆的、非共价的、具有口服活性的 BTK 抑制剂,能够作用于 WT-BTK (IC50:0.84 nM) 和 C481S-BTK (IC50:0.39 nM)。 | |||
T2655 | FAK ALK | ||
CEP-37440 是一种新型的 FAK (IC50:2.3 nM) 和 ALK (IC50:120 nM) 双重抑制剂。 | |||
T9706 | BTK | ||
BTK inhibitor 17 是口服有效的、不可逆的BTK 抑制剂,IC50为 2.1 nM。BTK inhibitor 17在类风湿关节炎方面有研究的价值。 | |||
T2302 | BTK | ||
CNX-774 是一种选择性的、具有口服活性的、不可逆的 BTK 抑制剂 (IC50<1 nM)。它能够特异性靶向 Btk 的 Cys 481进行共价修饰。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPY-02587 | Tyrosine Hydroxylase Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells | ||
Tyrosine Hydroxylase Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58 kDa and the accession number is P24529.
|
|||||
TMPY-02401 | Tyrosine Hydroxylase Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Tyrosine Hydroxylase Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P07101-3.
|
|||||
TMPY-00548 | HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.
|
|||||
TMPY-01944 | HER2/ERBB2 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
HER2/ERBB2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.2 kDa and the accession number is AAH61863.1.
|
|||||
TMPY-00636 | HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4.
|
|||||
TMPY-03024 | HER3/ERBB3 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
HER3/ERBB3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.9 kDa and the accession number is A6KSF8.
|
|||||
TMPY-03719 | HER2/ERBB2 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells | ||
HER2/ERBB2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.4 kDa and the accession number is A8WED5.
|
|||||
TMPY-02813 | ErbB4 Protein, Human, Rhesus, Recombinant (His) | Human,Rhesus | HEK293 Cells | ||
ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1.
|
|||||
TMPY-02477 | HER3/ERBB3 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
HER3/ERBB3 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is XP_005571238.1&XP_001113953.2.
|
|||||
TMPY-00246 | HER3/ERBB3 Protein, Rhesus, Recombinant | Rhesus | HEK293 Cells | ||
HER3/ERBB3 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.5 kDa and the accession number is XP_001113953.2.
|
|||||
TMPJ-00412 | VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinase domain. VEGFR-1is an essential receptor tyrosine kinase and plays an important role in theregulation of VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. It is also mediators of neurotrophic activity and regulators of hematopoietic development. VEGFR-1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF.It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells and promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. VEGFR-1 can also promote PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
|
|||||
TMPY-03215 | FLT3 Ligand Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
FLT3 Ligand Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.2 kDa and the accession number is P49771-1.
|
|||||
TMPY-06873 | FLT3 Ligand Protein, Human, Recombinant | Human | E. coli | ||
FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
|
|||||
TMPY-03066 | FLT3 Ligand Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is P49772-1.
|
|||||
TMPY-01601 | AXL Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1.
|
|||||
TMPY-04125 | PTP1B Protein, Human, Recombinant (His) | Human | E. coli | ||
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation.
|
|||||
TMPY-04649 | ROR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is Q01973.
|
|||||
TMPY-00930 | TIE2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1.
|
|||||
TMPY-01064 | TIE2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
|
|||||
TMPY-00637 | FLT1 Protein, Human, Recombinant (aa 1-328, His) | Human | HEK293 Cells | ||
FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accession number is L7RSL3.
|
|||||
TMPY-05394 | ROR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.8 kDa and the accession number is Q01974.
|
|||||
TMPY-01896 | HGFR/c-Met Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1.
|
|||||
TMPJ-00778 | HER2/ERBB2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
HER2/ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626.
|
|||||
TMPY-00882 | Mer Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
Mer Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 80 kDa and the accession number is Q12866.
|
|||||
TMPY-01247 | FLT3 Protein, Human, Recombinant (T227M, His) | Human | HEK293 Cells | ||
FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1.
|
|||||
TMPY-04330 | Mer Protein, Human, Recombinant | Human | HEK293 Cells | ||
Mer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 54 kDa and the accession number is Q12866.
|
|||||
TMPY-01084 | TrkA Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TrkA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is P04629-1.
|
|||||
TMPY-04384 | Src Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Src Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 87.7 kDa and the accession number is P12931-1.
|
|||||
TMPY-03484 | TCPTP Protein, Human, Recombinant | Human | Baculovirus Insect Cells | ||
TCPTP Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 36.8 kDa and the accession number is P17706-1.
|
|||||
TMPY-02231 | TrkB Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2.
|
|||||
TMPY-01936 | VEGFR3/FLT4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
VEGFR3/FLT4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is P35917-1.
|
|||||
TMPY-00751 | TrkB Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
|
|||||
TMPY-02365 | HER3/ERBB3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
HER3/ERBB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70 kDa and the accession number is Q61526.
|
|||||
TMPY-01296 | HGFR/c-Met Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
HGFR/c-Met Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is A0A024R759.
|
|||||
TMPY-02469 | HER2/ERBB2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
HER2/ERBB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.7 kDa and the accession number is P70424.
|
|||||
TMPY-00949 | VEGFR3/FLT4 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
VEGFR3/FLT4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is P35916-1.
|
|||||
TMPY-05308 | CD45 Protein, Human, Recombinant (aa 1-529, His) | Human | HEK293 Cells | ||
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5.
|
|||||
TMPY-02314 | HER2/ERBB2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
HER2/ERBB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is P70424.
|
|||||
TMPY-05748 | CD45 Protein, Human, Recombinant (aa 26-577, His) | Human | HEK293 Cells | ||
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.
|
|||||
TMPY-04396 | C-ABL/ABL1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
|
|||||
TMPY-01289 | DDR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1.
|
|||||
TMPY-04956 | HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
|
|||||
TMPY-00399 | HER3/ERBB3 Protein, Human, Recombinant | Human | HEK293 Cells | ||
HER3/ERBB3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.3 kDa and the accession number is P21860-1.
|
|||||
TMPY-01389 | HER3/ERBB3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
HER3/ERBB3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
|
|||||
TMPY-02508 | TIE2 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8.
|
|||||
TMPJ-01017 | Dtk Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Dtk Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P55144.
|
|||||
TMPJ-01081 | Dtk Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.
|
|||||
TMPY-05049 | TIE2 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9.
|
|||||
TMPY-06552 | AXL Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
AXL Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.72 kDa and the accession number is Q8VI99.
|
|||||
TMPY-04383 | CSK Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
CSK Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 77 kDa and the accession number is P41240.
|