Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl < Dtk < Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 540 | 5日内发货 | ||
50 μg | ¥ 1,170 | 5日内发货 | ||
500 μg | ¥ 5,250 | 5日内发货 | ||
1 mg | ¥ 7,510 | 5日内发货 |
生物活性 | Immobilized Human Dtk-His at 10μg/ml (100 μl/well) can bind Human GAS6-Fc. The ED50 of Human GAS6-Fc is 0.336 ug/ml. (Regularly tested) |
产品描述 | Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain. |
种属 | Human |
表达系统 | Human Cells |
标签 | C-6His |
蛋白编号 | Q06418 |
别名 | RSE, SKY, DTK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase receptor TYRO3, BYK, Tyrosine-protein kinase TIF, Tyrosine-protein kinase BYK, TIF, Tyrosine-protein kinase SKY, TYRO3 |
氨基酸序列 | Ala41-Ser428 |
蛋白构建 | Recombinant Human Tyrosine-protein Kinase Receptor TYRO3 is produced by our Mammalian expression system and the target gene encoding Ala41-Ser428 is expressed with a 6His tag at the C-terminus. |
蛋白纯度 | Greater than 90% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 55-70 KDa, reducing conditions |
内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
复溶方法 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
存储 |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
运输方式 |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
研究背景 | Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain. |
bottom
您可能有的问题的答案可以在重组蛋白操作手册中找到
Dtk Protein, Human, Recombinant (His) RSE SKY DTK TYRO 3 TYRO-3 Tyrosine-protein kinase DTK Tyrosine-protein kinase RSE Tyrosine-protein kinase receptor TYRO3 BYK Tyrosine-protein kinase TIF Tyrosine-protein kinase BYK TIF Tyrosine-protein kinase SKY TYRO3 recombinant recombinant-proteins proteins protein