目录号 | 产品详情 | 靶点 | |
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T12953 | Influenza Virus HIV Protease | ||
Sodium copper chlorophyllin B 对流感病毒和HIV 有抗病毒活性,IC50s 值都是 50 到 100 μM。 | |||
T12715 | HIV Protease | ||
Reverse transcriptase-IN-1 是一种二芳基苯并嘧啶类似物,是一种有效的 HIV-1 非核苷类逆转录酶抑制剂,IC50 为 13.7 nM。 | |||
T10111 | Others HIV Protease | ||
3-Deazaadenosine hydrochloride 是 S-腺苷高半胱氨酸水解酶的抑制剂,Ki 值为 3.9 µM。 它具有抗炎、抗增殖和抗 HIV 活性。 | |||
T9351 | SARS-CoV | ||
PF-07321332 是一种有效的口服活性 SARS-CoV 3CLPRO 抑制剂,对 SARS-CoV-2 病毒有针对性,可研究 COVID-19。它是一种胰蛋白酶样蛋白酶抑制剂,可抑制气道上皮钠通道功能。 | |||
T9063 | HIV Protease | ||
Clathrin-IN-1 是一种网格蛋白抑制剂,可通过与网格蛋白的末端域相关联来抑制网格蛋白介导的内吞作用,有潜力用于抗癌的研究。 | |||
T0682 | HIV Protease Reverse Transcriptase | ||
Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂,可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。 | |||
T15436 | HIV Protease | ||
GSK2838232 是一种新型人类免疫病毒成熟抑制剂,抑制 HIV 逆转录酶活性。 | |||
T6420 | HIV Protease | ||
BMS707035是一种 HIV-1 整合酶抑制剂,IC50为15 nM。 | |||
T2239 | HIV Protease Integrase | ||
Raltegravir potassium (MK 0518 potassium salt) 是一种整合酶抑制剂,用于研究 HIV 感染。 | |||
T6388 | SARS-CoV HIV Protease | ||
Amprenavir (KVX-478) 是一种 HIV 蛋白酶抑制剂,Ki 为0.6 nM。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.09 μM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02882 | HIV-1 (group M, subtype CRF07_BC) gp140 Protein (His) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype CRF07_BC) gp140 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.2 kDa.
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TMPY-01552 | HIV-1 (group M, subtype B, strain 92418) p24 Protein (His) | HIV | E. coli | ||
HIV-1 (group M, subtype B, strain 92418) p24 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.5 kDa and the accession number is B6DRA0.
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TMPY-01373 | HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.8 kDa and the accession number is I6TSC9.
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TMPY-04192 | HIV-1 (group M, subtype B, strain HXB2) p24 Protein (His) | HIV | E. coli | ||
HIV-1 (group M, subtype B, strain HXB2) p24 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P04591.
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TMPJ-01313 | HIV-1 gp120 Protein (His) | HIV | HEK293 Cells | ||
Envelope glycoprotein gp160 is single-pass type I membrane protein. The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. It is cleaved into the following 2 chains: glycoprotein 120 and transmembrane protein gp41. The resulting complex protrudes from the virus surface as a spike. The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.
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TMPH-01522 | HIV-2 (subtype A, isolate ROD) Protein Vpx (His) | HIV-2 | P. pastoris (Yeast) | ||
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
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TMPH-01521 | HIV-2 (subtype A, isolate BEN) Protein Vpx (His) | HIV-2 | E. coli | ||
HIV-2 (subtype A, isolate BEN) Protein Vpx (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.2 kDa and the accession number is P18099.
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TMPY-00426 | HIV-1 (group P, strain RBF168) gp140 Protein (hFc) | HIV | HEK293 Cells | ||
HIV-1 (group P, strain RBF168) gp140 Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 99.4 kDa and the accession number is D0VTQ8.
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TMPY-04196 | HIV-1 (group M, subtype D, strain NDK) p24 Protein (His) | HIV | E. coli | ||
HIV-1 (group M, subtype D, strain NDK) p24 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P18800.
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TMPY-04915 | HIV-1 (group M, subtype B, Isolate MN) gp120 Protein (His) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype B, Isolate MN) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is Q9YUL5.
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TMPY-04198 | HIV-1 (group O, strain BCF06) p24 Protein (His) | HIV | E. coli | ||
HIV-1 (group O, strain BCF06) p24 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.6 kDa and the accession number is C7G2S7.
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TMPY-00427 | HIV-1 (group P, strain RBF168) gp120 Protein (His) | HIV | HEK293 Cells | ||
HIV-1 (group P, strain RBF168) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.2 kDa and the accession number is D0VTQ8.
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TMPY-00316 | HIV-1 (group M, subtype B, isolate BAL) gp120 Protein (His) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype B, isolate BAL) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.4 kDa and the accession number is Q03805.
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TMPY-01408 | HIV-1 (group M, subtype CRF07_BC) gp140 Protein (hFc) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype CRF07_BC) gp140 Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 98 kDa.
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TMPY-01556 | HIV-1 (group N, strain 06CM-U14296) p24 protein (His) | HIV | E. coli | ||
HIV-1 (group N, strain 06CM-U14296) p24 protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 27 kDa.
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TMPY-06486 | HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His), Biotinylated | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.8 kDa and the accession number is AFM77980.1.
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TMPY-00425 | HIV-1 (group M, subtype A, strain 92UG037.1) gp140 Protein (hFc) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype A, strain 92UG037.1) gp140 Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 97.4 kDa and the accession number is P90249.
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TMPH-01519 | HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc) | HIV-1 | E. coli | ||
HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.9 kDa and the accession number is O12160.
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TMPY-04061 | HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP) | HIV | E. coli | ||
HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 58.8 kDa and the accession number is L8B302.
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TMPY-04871 | HIV-1 (group M, subtype C, strain 92BR025) gp140 Protein (Fc) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype C, strain 92BR025) gp140 Protein (Fc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 99.9 kDa and the accession number is O12164.
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TMPY-04194 | HIV-1 (group M, subtype C, strain 92BR025) p24 Protein (His) | HIV | E. coli | ||
HIV-1 (group M, subtype C, strain 92BR025) p24 Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 26.5 kDa and the accession number is O12157.
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TMPY-00309 | HIV-1 (group M, subtype B, strain SHIV-89.6P) gp120 Protein (His) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype B, strain SHIV-89.6P) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.4 kDa and the accession number is O11407.
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TMPH-01520 | HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc) | HIV-1 | E. coli | ||
HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.8 kDa and the accession number is P0C1P2.
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TMPY-01558 | HIV-1 (group N, strain 06CM-U14296) gp160 (gp120 subunit) Protein (His) | HIV | HEK293 Cells | ||
HIV-1 (group N, strain 06CM-U14296) gp160 (gp120 subunit) Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.4 kDa.
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TMPY-00302 | HIV-1 (group M, subtype A, isolate 92RW020) gp160 (gp120 subunit) Protein (His) | HIV | HEK293 Cells | ||
HIV-1 (group M, subtype A, isolate 92RW020) gp160 (gp120 subunit) Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.2 kDa and the accession number is Q6BC58.
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TMPY-04150 | HIV-p51/RT-p51 (group M, subtype B (isolate HXB2) Gag-Pol polyprotein Protein (His) | HIV | E. coli | ||
HIV-p51/RT-p51 (group M, subtype B (isolate HXB2) Gag-Pol polyprotein Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 53.6 kDa and the accession number is P04585.
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TMPY-04161 | HIV-p66/RT-p66 (group M, subtype B (isolate HXB2) Gag-Pol polyprotein Protein (His) | HIV | E. coli | ||
HIV-p66/RT-p66 (group M, subtype B (isolate HXB2) Gag-Pol polyprotein Protein (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 66.7 kDa and the accession number is P04585.
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TMPY-01442 | DMBT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are involved in the development of glioma (GLM). Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas , and ependymomas. DMBT1 may be considered as a candidate tumor suppressor for brain, lung, esophageal, gastric, and colorectal cancers. It may play roles in mucosal defense system, cellular immune defense and epithelial differentiation. DMBT1 may play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. It may be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. DMBT1 may function as a binding protein in saliva for the regulation of taste sensation. It binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.
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TMPH-00777 | Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His) | Griffithsia | E. coli | ||
Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine.
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TMPH-00776 | Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His & Myc) | Griffithsia | Baculovirus Insect Cells | ||
Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine.
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TMPK-01231 | CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells | ||
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies.
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TMPK-01230 | CLEC2D Protein, Human, Recombinant (hFc & Avi) | Human | HEK293 Cells | ||
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. However, this implication may be confounded by highly active anti-retroviral treatment (HAART).
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TMPJ-00873 | CCL3L1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
C-C Motif Chemokine 3-Like 1 (CCL3L1) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. CCL3L1 is a ligand for CCR1, CCR3 and CCR5. CCL3L1 binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The processed form LD78-beta (3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. The copy number of this gene varies among individuals: most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more centromeric full-length gene.
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TMPJ-00048 | CYPA Protein, Mouse, Recombinant | Mouse | E. coli | ||
Peptidyl-prolyl cis-trans isomerase A is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins(CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.
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TMPH-02300 | RAD23A Protein, Human, Recombinant (His) | Human | E. coli | ||
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.
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TMPH-01248 | ADAR Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication.
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TMPJ-01330 | CD299 Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells | ||
CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp12, HIV-2 gp12, SIV gp12, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation.
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TMPK-00896 | CCR8 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 30.62 kDa and the accession number is P51685-1.
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TMPK-00897 | CCR8 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 30.25 kDa and the accession number is P51685-1.
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TMPK-01316 | CCR8 Protein, Cynomolgus, Recombinant (mFc) | Cynomolgus | HEK293 Cells | ||
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 29.73 kDa and the accession number is A0A8J8XUI3.
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TMPH-01064 | CCR4 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.0 kDa and the accession number is P51679.
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TMPH-01065 | CCR4 Protein-VLP, Human, Recombinant (His) | Human | HEK293 Cells | ||
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 43.2 kDa and the accession number is P51679.
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TMPY-03285 | PPIL1 Protein, Human, Recombinant (His) | Human | E. coli | ||
PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take a significant part in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL1 is a peptidylprolyl isomerase(PPIase). It increases the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of stathmin. It is a novel molecular target for colon-cancer therapy.
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TMPY-03413 | PPIL2 Protein, Human, Recombinant (aa 280-457, His) | Human | E. coli | ||
PPIL2, is an enzyme that belongs to the cyclophilin family. The cyclophilins are peptidylprolyl isomerases and are highly conserved ubiquitous. They play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL2 interacts with the proteinase inhibitor eglin c and is localized in the nucleus. It contains 1 PPIL2 cyclophilin-type domain and 1 U-box domain. PPIL2 accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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TMPK-00668 | IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His) | Cynomolgus | HEK293 Cells | ||
IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.
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TMPJ-00810 | ITGA5 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Integrin α-5 belongs to the Integrin α chain family and contains 7 FG-GAP repeats. Integrin α-5 joins with Integrin-β1 to form a fibronectin and laminin receptor which recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. It is expressed on fibroblasts, endothelial cells, peripheral T cells and platelets. Integrin α-5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains. In addition to adhesion, ITGA5 participates in cell-surface mediated signalling.
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TMPJ-01037 | CXCR4 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. CXCR4 stands out for its pleiotropic roles in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.
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TMPJ-00679 | SGTA Protein, Human, Recombinant (His) | Human | E. coli | ||
Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein α (SGTA) is an ubiquitously expressed protein which belongs to the SGT Family. SGTA contains three TPR Protein-Protein Interaction Duplicates. SGTA is a co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. SGTA is capable of interacting with the major nonstructural protein of Parvovirus H-1 and 70-kDa heat shock cognate protein. It interacts with NS1 from Parvovirus H-1, with Vpu and Gag from HIV-1. It also interacts with SARS-CoV Accessory Protein 7a, DNAJC5 and DNAJC5B. However, its function is not known. Since this transcript is expressed ubiquitously in various tissues, SGTA may serve a housekeeping function.
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TMPJ-00621 | LILRB1/CD85j/ILT2 Protein, Rhesus macaque, Recombinant (aa 17-456, His) | Rhesus | HEK293 Cells | ||
LILRB1, also known as CD85j and ILT2, is a transmembrane glycoprotein in the LILR immunoregulatory protein family. LILRB1 is expressed on NK cells that have expanded in response to acute HCMV infection. LILRB1 exhibits considerable diversity in the population, and polymorphisms in the LILRB1 gene have been associated with susceptibility to rheumatoid arthritis and weakly associated with HCMV disease in a subset of patients with HIV. The regulation of phagocytosis by macrophages is an additional key role of LILRB1 signaling. LILRB1 recognizes a wide variety of HLA haplotypes due to its interaction with the invariant β2M subunit of MHC class I, which suggests that this signaling axis is relevant across diverse patient populations.
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TMPJ-00394 | LDLR Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells | ||
Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR will result in familial hypercholesterolemia.
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