目录号 | 产品详情 | 靶点 | |
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T2358 | Apoptosis VEGFR FGFR FLT c-RET PDGFR Src Aurora Kinase | ||
ENMD2076是一种多靶点激酶抑制剂,抑制Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1、FGFR2、Src、PDGFRα的IC50值分别为1.86、14、58.2、15.9、92.7、70.8、20.2 and 56.4 nM。 | |||
T61977 | |||
FLT3/D835Y-IN-1 (化合物13a) 是一种选择性的、口服活性的FLT3和FLT3/D835Y 抑制剂,IC50分别为 0.26 nM 和 0.18 nM。FLT3/D835Y-IN-1 具有抗癌作用,可以用于急性髓系白血病的研究。 | |||
T63135 | |||
FLT3/CDK4-IN-1 是一种高度选择性的、有效的、口服具有活力的 FLT3/CDK4 双重抑制剂,作用于 FLT3 (IC50: 7 nM) 与 CDK4 (IC50: 11 nM)。FLT3/CDK4-IN-1 在体内具有良好的抗肿瘤效果,对某些癌细胞表现出抗增殖作用。 | |||
T2677 | FLT PDGFR Autophagy | ||
Crenolanib (ARO 002) 是一种口服生物可利用的 III 型酪氨酸激酶抑制剂,抑制 FLT3和 PDGFRα/β的 IC50分别为 4、11和 3.2 nM。 | |||
T2467 | Apoptosis FLT Syk | ||
R406 free base (R406(free base)) 是一种具有口服活性的,ATP 竞争性的Syk/FLT3抑制剂,Ki 为 30 nM。它有效抑制 Syk 激酶活性,IC50为 41 nM,可减轻免疫复合物介导的炎症。它还抑制 Lyn 和 Lck,IC50分别为 63 nM 和 37 nM。 | |||
T41003 | Raf FLT PDGFR c-Kit | ||
KG5 是 PDGFRβ 和 B-Raf 的双重变构抑制剂,对 PDGFRβ 和 PDGFRα 的 Kd 分别为 520 nM 和 300 nM。 KG5 抑制 FLT3、KIT 和 c-Raf,具有抗癌和抗血管生成活性。 | |||
T4209 | VEGFR FLT Tyrosine Kinases JAK Syk | ||
TAK-659 hydrochloride (TAK-659) 是可逆的、高效的、选择性的、口服有效的 SYK/FLT3 双抑制剂,对 SYK 和 FLT3 作用的IC50值分别为 3.2 nM、4.6 nM。它能诱导肿瘤细胞死亡,却不作用于非肿瘤细胞,对慢性淋巴细胞白血病具有潜在的研究价值。 | |||
T82392 | |||
FLT3-IN-23作为JFMS样脂氨酸激酶3(FLT3)的抑制剂,表现出7.42 nM的IC50值。该化合物针对带有多种FLT3-TKD与FLT3-ITD-TKD突变的BaF3细胞显示出显著的抗增殖效果。 | |||
T0093 | Apoptosis Raf VEGFR FLT Ferroptosis PDGFR c-Kit Autophagy | ||
Sorafenib tosylate (Bay 43-9006) 是一种口服活性Raf 抑制剂,也是铁死亡激动剂。它是多激酶抑制剂,对VEGFR2,VEGFR3,PDGFRβ,FLT3和c-Kit 的IC50分别为 90 nM,15 nM,20 nM,57 nM 和 58 nM。它诱导细胞自噬和凋亡,有抗肿瘤活性。 | |||
T8482 | Apoptosis VEGFR FLT PDGFR c-Kit | ||
Ripretinib (DCC-2618) 是一种口服生物利用的,选择性 KIT 和 PDGFRA 开关控制抑制剂,具有抗肿瘤作用并诱导细胞凋亡。它专门针对 KIT 和 PDGFRA 的野生型和突变型并与之结合在其开关口袋结合位点,从而防止这些激酶从无活性构象转变为有活性构象,并使它们的野生型和突变体形式失活。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPK-00929 | FLT3 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. FLT3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 84.78 kDa and the accession number is Q00342.
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TMPK-00125 | FLT3 Ligand Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. FLT3 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 44.8 kDa and the accession number is P49771-1.
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TMPY-06873 | FLT3 Ligand Protein, Human, Recombinant | Human | E. coli | ||
FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
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TMPY-03066 | FLT3 Ligand Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is P49772-1.
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TMPY-03215 | FLT3 Ligand Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
FLT3 Ligand Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.2 kDa and the accession number is P49771-1.
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TMPY-01247 | FLT3 Protein, Human, Recombinant (T227M, His) | Human | HEK293 Cells | ||
FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1.
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TMPK-00523 | FLT3 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
FLT3 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 84.58 kDa and the accession number is A0A2K5VQ48.
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TMPK-00416 | FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | CHO Cells | ||
FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in CHO mammalian cells with C-His-Avi tag. The predicted molecular weight is 61.20 kDa and the accession number is P36888-1.
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TMPY-05738 | FLT3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
FLT3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 85.06 kDa and the accession number is P36888-1.
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TMPY-03704 | FLT3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FLT3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.4 kDa and the accession number is EDL05832.1.
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TMPJ-00123 | FLT3LG Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Fms-related tyrosine kinase 3 ligand(Flt3L) is a single-pass type I membrane protein and consists of 232 amino acids. Flt3L is a hematopoietic four helical bundle cytokine, structurally homologous to stem cell factor and colony stimulating factor. Flt3L synergizes well with a number of other colony stimulating factors and interleukins. Flt3L stimulates the proliferation and differentiation of various blood cell progentiors by activating FLT3.
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TMPY-05332 | FLT3 Ligand Protein, Rat, Recombinant (His) | Rat | Baculovirus Insect Cells | ||
FLT3 Ligand Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is NP_001292868.1.
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TMPY-06938 | FLT3 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells | ||
FLT3 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 86.87 kDa and the accession number is NP_004110.2.
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TMPY-02842 | UBE2L6 Protein, Human, Recombinant (His) | Human | E. coli | ||
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain. These domains accommodate the ATP-activated ubiquitin (Ub) or ubiquitin-like (UBL) protein via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the E1 and E3 enzymes and connect activation to covalent modification. By doing so, E2s differentiate effects on downstream substrates, either with a single Ub/UBL molecule or as a chain. UBCH8 is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. It catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. UBCH8 functions in the E6/E6-AP-induced ubiquitination of p53/TP53 and promotes ubiquitination and subsequent proteasomal degradation of FLT3. At protein level, it is present in natural killer cells.
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