目录号 | 产品详情 | 靶点 | |
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T78081 | |||
Farnesyl pyrophosphate ammonium salt为15碳类异戊二烯代谢中间体,源自MVA途径,兼具TRPM2激动剂功能,能够触发TRPM2通道开放并促进离子流入细胞。它亦是胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及GGPP合成的关键底物。 | |||
T35922 | |||
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then stimulates large-scale calcium release from granules and the endoplasmic reticulum mediated by type 1 ryanodine receptors (RyR2s), RyR3s, and inositol-(1,4,5)-triphosphate receptors (IP3Rs). NAADP induces calcium mobilization in sea urchin and starfish eggs post fertilization to block polyspermy and activate embryogenesis. NAADP-induced calcium mobilization induces VEGF-mediated angiogenesis in human umbilical vein endothelial cells (HUVECs). It also alkalizes lysosomal pH thereby inhibiting fusion between autophagosomes and lysosomes and arresting autophagic flux in mouse embryonic stem cells. | |||
T75797 | |||
β-Pompilidotoxin TFA (β-PMTX TFA) 是能够减缓钠通道 (sodium channel) 的失活并增加细胞中的稳态钠电流的黄蜂毒液。 | |||
T35497 | |||
Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and is increased following dietary supplementation with ω-3 fatty acids. (±)7(8)-EpDPA and other epoxy metabolites of DHA modulate receptor and channel activities to evoke diverse effects, such as promoting vasodilation, inhibiting angiogenesis, and decreasing inflammatory and neuropathic pain. (±)7(8)-EpDPA is a substrate of soluble epoxide hydrolase (KM = 15 μM), which converts it to the corresponding diol. | |||
T68499 | |||
F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotective effects following ischemia. In vitro testing showed minimal effects of F15845 on other important ion channels of the heart, including major Ca2+ and K+ channels.[1] This characteristic is thought to account for the limited effect of F15845 to change other heart parameters such as basal cardiac function, hemodynamic functions and ventricular fibrillation. F15845 was also shown to exert improved effects when the membrane potential was depolarized,[1] by acting on the extracellular side of the channel. | |||
T80172 | Potassium Channel | ||
Stromatoxin 1是从狼蛛中分离出的肽类钾通道抑制剂,特异性地抑制K(V)2.1、K(V)2.2、K(V)4.2和K(V)2.1/9.3通道。其中,K(V)2.1和K(V)2.2通道亚基对大鼠肌源性和神经源性膀胱平滑肌(UBSM)的收缩起关键调控作用,然而K(V)4.2则不参与此作用。 | |||
T78066 | Calcium Channel | ||
BBT是一种增强剂,用于改善受损的葡萄糖刺激胰岛素分泌(GSIS)。该化合物展现出抗高血糖的活性,并能在2型糖尿病模型中,对β细胞起到保护作用,抵御细胞因子或链脲佐菌素(STZ)引起的细胞死亡。BBT的作用机制涉及通过cAMP/PKA及持久(L型)电压依赖性Ca2+通道/CaMK2通路。 | |||
T75726 | |||
ω-Conotoxin MVIIC TFA 是一种阻断N和P/Q型钙通道(Ca2+ channel)的化合物,能显著抑制由11-keto-βboswellic acid介导的谷氨酸释放。 | |||
T72181 | |||
P-CAB agent 2 hydrochloride 为具有口服活性的高效钾竞争性酸(potassium-competitive acid)阻滞剂及胃酸分泌抑制剂,能够抑制 H+/K+-ATPase 活性,其 IC50 值小于100 nM。同时,对 hERG 钾通道的抑制 IC50 值为18.69 M,表明无急性毒性并能够抑制组胺诱导的胃酸分泌。 | |||
TN1875 | BCL Caspase p53 | ||
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibiti |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-01363 | CLIC5 Protein, Human, Recombinant (His) | Human | E. coli | ||
Chloride Intracellular Channel Protein 5 (CLIC5) is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain. Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 can insert into membranes and form selective ion channels regulated by actin that may transport chloride ions. It may play a role in the regulation of transepithelial ion absorption and secretion. CLIC5 specifically associates with the cytoskeleton of placenta microvilli. CLIC5 is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture.
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TMPY-04075 | CLIC1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. Chloride intracellular channel 1 (CLIC1), a newly discovered member of the chloride channel protein family, has been implicated in multiple human cancers. CLIC1 is a Chloride Intracellular Ion Channel protein that exists either in a soluble state in the cytoplasm or as a membrane bound protein. CLIC1 acts as a putative oncogene in pancreatic cancer and may represent a novel diagnostic and therapeutic target for pancreatic cancer. Intracellular chloride channel protein 1 (CLIC1) participates in inflammatory processes by regulating macrophage phagosomal functions such as pH and proteolysis. CLIC1 is a novel therapeutic target to help reduce the adaptive immune response in autoimmune diseases. The expression of CLIC1 might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of pancreatic ductal adenocarcinomas. Intracellular chloride channel 1 (CLIC1), a novel metamorphic protein, acts as a sensor of cell oxidation and is involved in inflammation.
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TMPJ-00719 | CLIC3 Protein, Human, Recombinant (His) | Human | E. coli | ||
Chloride intracellular channel protein 3 (CLIC3) is encoded by the CLIC3 gene. CLIC3 is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain and one GST N-terminal domain. Chloride intracellular channel protein 3 high expressed in the placental, lung and heart, low expressed in skeletal muscle, kidney and pancreas. Chloride intracellular channel protein 3 can insert into membranes and forms chloride ion channels, may participate in cellular growth control.
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TMPY-03183 | SCN2B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
SCN2B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.2 kDa and the accession number is O60939.
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TMPJ-00666 | CLIC2 Protein, Human, Recombinant (His) | Human | E. coli | ||
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be detected in the adult brain, liver, lung, heart, stomach, spleen and testis. It is expressed in fetal liver and adult skeletal muscle. CLIC2 is a potential candidate for one of many diseases linked to Xq28.
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TMPH-01279 | CRACR2B Protein, Human, Recombinant (His) | Human | E. coli | ||
Plays a role in store-operated Ca(2+) entry (SOCE).
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TMPH-02523 | AQP2 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. AQP2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.5 kDa and the accession number is P56402.
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TMPY-03697 | SCN2B Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SCN2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.7 kDa and the accession number is O60939.
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TMPH-03246 | AQP2 Protein, Rat, Recombinant (His) | Rat | E. coli | ||
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. AQP2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.4 kDa and the accession number is P34080.
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TMPY-03615 | CSEN Protein, Human, Recombinant (His) | Human | E. coli | ||
KCNIP3 (Potassium Voltage-Gated Channel Interacting Protein 3, also known as CSEN) is a Protein Coding gene. CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. CSEN also functions as a calcium-regulated transcriptional repressor and interacts with presenilins. CSEN binds to the DRE element of genes including PDYN and FOS. CSEN is broadly expressed in the brain, thyroid, and other tissues. Diseases associated with KCNIP3 include Alzheimer's Disease and Niemann-Pick Disease, Type C2.
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TMPH-00780 | CACNA1C Protein, Guinea Pig, Recombinant (His) | Guinea pig | E. coli | ||
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
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TMPH-00952 | Aquaporin-1/AQP1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Aquaporin-1/AQP1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPY-01890 | CLIC4 Protein, Human, Recombinant (His) | Human | E. coli | ||
Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. CLIC4 could promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Expression of CLIC4 is prominent in heart, kidney, placenta and skeletal muscle. Overexpression of CLIC4 in cancer cells inhibits tumor growth. Conversely, overexpression of CLIC4 in tumor stromal cells stimulates tumor growth. Thus, CLIC4 participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation. Loss of CLIC4 in tumor cells and gain in tumor stroma is common to many human cancers and marks malignant progression. Up-regulation of CLIC4 in tumor stroma is coincident with myofibroblast conversion, generally a poor prognostic indicator. Reactivation and restoration of CLIC4 in tumor cells or the converse in tumor stromal cells could provide a novel approach to inhibit tumor growth.
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TMPY-02976 | SCN3B Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SCN3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.2 kDa and the accession number is Q9NY72.
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TMPY-02722 | SCN3B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
SCN3B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.5 kDa and the accession number is Q9NY72.
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TMPH-00953 | Aquaporin-4/AQP4 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Aquaporin-4/AQP4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-02308 | CACNA2D1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
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TMPH-02980 | Aquaporin-4/AQP4 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
Aquaporin-4/AQP4 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 9.9 kDa and the accession number is P55088.
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TMPH-00580 | Aquaporin Z Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Aquaporin Z Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.7 kDa and the accession number is P60844.
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TMPH-03209 | CLNS1A Protein, Rabbit, Recombinant (His & Myc) | Rabbit | E. coli | ||
CLNS1A Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.4 kDa and the accession number is Q28678.
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TMPH-01300 | Stomatin/STOM Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
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TMPH-02331 | GLRA1 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol.
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TMPH-03603 | KcsA Protein, S. coelicolor, Recombinant (His) | Streptomyces coelicolor | E. coli | ||
Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel. KcsA Protein, S. coelicolor, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 23.7 kDa and the accession number is P0A333.
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TMPH-01394 | GRIN1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 64.6 kDa and the accession number is Q05586.
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TMPH-01609 | LGI1 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
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TMPH-03381 | Synaptoporin/SYNPR Protein, Rat, Recombinant (His) | Rat | E. coli | ||
Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein. Synaptoporin/SYNPR Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 35.2 kDa and the accession number is P22831.
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TMPH-00596 | Colicin-E1 Protein, E. coli, Recombinant (Cell-Free, His & Myc) | E. coli | E. coli | ||
This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.; Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
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TMPH-00597 | Colicin-E1 Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
This colicin is a channel-forming colicin. This class of transmembrane toxins depolarize the cytoplasmic membrane, leading to dissipation of cellular energy.; Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
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TMPH-00872 | CHRNE Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNE Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.5 kDa and the accession number is Q04844.
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TMPH-02487 | CHRNA1 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-His tag. The predicted molecular weight is 26.5 kDa and the accession number is P04756.
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TMPH-02638 | HSPA5 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli | ||
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1. Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation.
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TMPY-03609 | ATP5D Protein, Human, Recombinant (His) | Human | E. coli | ||
ATP5D is a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase consists of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). ATP5D gene encodes the delta subunit of the catalytic core.
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TMPH-00873 | CHRNG Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNG Protein, Human, Recombinant (His) is expressed in yeast with N-His tag. The predicted molecular weight is 27.5 kDa and the accession number is P07510.
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TMPH-01691 | TOMM40 Protein, Human, Recombinant (GST) | Human | E. coli | ||
Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria.
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TMPH-01009 | RHD Protein, Human, Recombinant (GST & His) | Human | E. coli | ||
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. RHD Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 33.6 kDa and the accession number is Q02161.
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TMPH-00871 | CHRNA1 Protein, Human, Recombinant (His) | Human | E. coli | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is P02708.
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TMPH-03620 | CHRNA1 Protein, Tetronarce californica, Recombinant (E. coli, His) | Torpedo californica | E. coli | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Tetronarce californica, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is P02710.
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TMPH-03621 | CHRNA1 Protein, Tetronarce californica, Recombinant (His) | Tetronarce californica | HEK293 Cells | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Tetronarce californica, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 28.4 kDa and the accession number is P02710.
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TMPH-01762 | CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 44.6 kDa and the accession number is P32297.
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TMPH-00670 | MscL Protein, E. coli O157:H7, Recombinant (B2M & His) | E. coli | E. coli | ||
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. MscL Protein, E. coli O157:H7, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 29.0 kDa and the accession number is P0A743.
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TMPH-02336 | TAS2R10 Protein, Human, Recombinant (His & KSI) | Human | E. coli | ||
Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. TAS2R10 Protein, Human, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 19.6 kDa and the accession number is Q9NYW0.
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TMPH-00874 | CHRNG Protein, Human, Recombinant (E. coli, His) | Human | E. coli | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNG Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.6 kDa and the accession number is P07510.
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TMPH-02486 | CHRNA1 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.5 kDa and the accession number is P04756.
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TMPH-02551 | CD20 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. CD20 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 22.3 kDa and the accession number is P19437.
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TMPH-01763 | CHRNB2 Protein, Human, Recombinant (His & V5) | Human | E. coli | ||
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. CHRNB2 Protein, Human, Recombinant (His & V5) is expressed in E. coli expression system with N-10xHis-V5 tag. The predicted molecular weight is 31.9 kDa and the accession number is P17787.
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TMPH-02347 | Influenza A H1N1 (strain A/USA:Phila/1935) Matrix protein 2 (His) | H1N1 | E. coli | ||
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
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TMPH-02348 | Influenza A H1N1 (strain A/Puerto Rico/8/1934) Matrix protein 2 (His & Myc) | H1N1 | E. coli | ||
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
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TMPH-03623 | Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc) | Tityus bahiensis | Baculovirus Insect Cells | ||
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against both mammals and insects. Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.8 kDa and the accession number is P60276.
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TMPH-02905 | TRPC1 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. TRPC1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 94.0 kDa and the accession number is Q61056.
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TMPJ-01076 | FKBP4 Protein, Human, Recombinant (His) | Human | E. coli | ||
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
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