FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 340 | 5日内发货 | ||
50 μg | ¥ 820 | 5日内发货 | ||
500 μg | ¥ 8,860 | 5日内发货 | ||
1 mg | ¥ 12,600 | 5日内发货 |
产品描述 | FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
种属 | Human |
表达系统 | E. coli |
标签 | C-6His |
蛋白编号 | Q02790 |
别名 | FKBP4, HSP-binding immunophilin, immunophilin FKBP52, FK506-binding protein 4, FKBP59, Rotamase, 59kDa immunophilin, 51kDa FK506-binding protein, Peptidyl-prolyl cis-trans isomerase FKBP4 |
氨基酸序列 | Met1-Ala459 |
蛋白构建 | Recombinant Human 52 kDa FK506 Binding Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala459 is expressed with a 6His tag at the C-terminus. |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 50-60 KDa, reducing conditions |
内毒素 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Glycerol, pH 8.0. |
存储 |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
运输方式 |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
研究背景 | FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
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FKBP4 Protein, Human, Recombinant (His) FKBP-59 FKBP4 HSP-binding immunophilin immunophilin FKBP52 FKBP 59 FK506-binding protein 4 FKBP-4 FKBP59 Rotamase FKBP 4 59kDa immunophilin 51kDa FK506-binding protein Peptidyl-prolyl cis-trans isomerase FKBP4 recombinant recombinant-proteins proteins protein