|
TMPK-01158
|
Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)
|
Mouse
|
HEK293 Cells
|
|
The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.
|
|
TMPY-01900
|
Kallikrein 4/KLK4 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transition- and maturation-stage ameloblasts. KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion. Two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-2). The late protease is kallikrein 4 (KLK4). The principal functions of MMP-2 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins. Defects in Kallikrein-4 / KLK4 are the cause of Amelogenesis Imperfecta Hypomaturation type 2A1 (AI2A1) which is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions.
|
|
TMPY-05289
|
Kallikrein 15/KLK15 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Kallikrein 15/KLK15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.8 kDa and the accession number is Q9H2R5-1.
|
|
TMPY-00491
|
Kallikrein 15/KLK15 Protein, Human, Recombinant (hFc)
|
Human
|
HEK293 Cells
|
|
Kallikrein 15/KLK15 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q9H2R5-1.
|
|
TMPY-04032
|
Kallikrein 1/KLK1 Protein, Mouse, Recombinant (His)
|
Mouse
|
HEK293 Cells
|
|
Kallikrein 1/KLK1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.3 kDa and the accession number is P15947.
|
|
TMPY-00866
|
Kallikrein 1/KLK1 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Kallikrein 1/KLK1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28 kDa and the accession number is A0A1R3UCD2.
|
|
TMPJ-00891
|
Kallikrein 2/KLK2 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.
|
|
TMPJ-00475
|
Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His)
|
Human
|
HEK293 Cells
|
|
Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The function of KLK1 is to cleave Kininogen in order to release the vasoactive Kinin peptide (Lysyl-Bradykinin or Bradykinin). The Kinin peptide controls blood pressure reduction, vasodilation, smooth muscle relaxation and contraction, pain induction and inflammation. KLK1 also plays a role in angiogensis and tumorigenesis.
|
|
TMPJ-00931
|
Serpin A4 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and secreted in plasma. Serpin A4 is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. It can inhibit intracellular reactive oxygen species formation in cultured cardiac and renal cells. In addition, Serpin A4 has anti-inflammatory effect. Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.
|
|
TMPY-04451
|
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
|
Human
|
Baculovirus Insect Cells
|
|
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&Q13131-1.
|
|
TMPY-03745
|
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)
|
Human
|
HEK293 Cells
|
|
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
|
|
TMPY-06531
|
IL-15 & IL-15RA Protein, Mouse, Recombinant (His)
|
Mouse
|
HEK293 Cells
|
|
IL-15 & IL-15RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.46 kDa and the accession number is P48346-1 & Q60819-1.
|
|
TMPY-03878
|
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
|
Human
|
HEK293 Cells
|
|
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
|
|
TMPY-02501
|
CD3D & CD3E Heterodimer Protein, Human, Recombinant
|
Human
|
HEK293 Cells
|
|
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
|
|
TMPY-04069
|
Neurotrophin 3 Protein, Human, Recombinant
|
Human
|
E. coli
|
|
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. NTF3 is capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-200c. NTF3 is broadly expressed in the ovary, spleen, and other tissues. Diseases associated with NTF3 include Hypochondriasis and Demyelinating Disease.
|
|
TMPY-00586
|
CLEC-2 Protein, Mouse, Recombinant (hFc)
|
Mouse
|
HEK293 Cells
|
|
CLEC-2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9JL99-1.
|
|
TMPY-00986
|
IL-34 Protein, Mouse, Recombinant (His)
|
Mouse
|
HEK293 Cells
|
|
IL-34 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is Q8R1R4-1.
|
|
TMPY-00991
|
LIFR Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
LIFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 91 kDa and the accession number is P42702-1.
|
|
TMPY-02412
|
ENO1 Protein, Human, Recombinant (His)
|
Human
|
E. coli
|
|
ENO1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 49.3 kDa and the accession number is P06733-1.
|
|
TMPY-03956
|
Fas Ligand Protein, Human, Recombinant (His)
|
Human
|
P. pastoris (Yeast)
|
|
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 19.3 kDa and the accession number is P48023-1.
|
|
TMPY-04413
|
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)
|
Human
|
Baculovirus Insect Cells
|
|
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 86 kDa and the accession number is O75460-1.
|
|
TMPY-03363
|
C-Reactive Protein Protein, Human, Recombinant
|
Human
|
HEK293 Cells
|
|
C-Reactive Protein Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23 kDa and the accession number is P02741-1.
|
|
TMPY-01349
|
ICAM-1/CD54 Protein, Mouse, Recombinant (His)
|
Mouse
|
HEK293 Cells
|
|
ICAM-1/CD54 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.7 kDa and the accession number is P13597-1.
|
|
TMPY-05354
|
CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
|
Human
|
HEK293 Cells
|
|
CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 43.7 kDa and the accession number is P10747-1.
|
|
TMPY-00915
|
Serpin A1 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Serpin A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is P01009-1.
|
|
TMPY-01139
|
PDGFRA Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1.
|
|
TMPY-04956
|
HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated
|
Human
|
HEK293 Cells
|
|
HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
|
|
TMPY-02617
|
Influenza A H2N2 (A/Ann Arbor/6/1960) Nucleoprotein/NP Protein (His)
|
H2N2
|
Baculovirus Insect Cells
|
|
Influenza A H2N2 (A/Ann Arbor/6/1960) Nucleoprotein/NP Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P21433-1.
|
|
TMPY-05435
|
ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)
|
Human
|
HEK293 Cells
|
|
ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is Q15389-1.
|
|
TMPY-01853
|
SIRP gamma Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
SIRP gamma Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.5 kDa and the accession number is Q9P1W8-1.
|
|
TMPY-06051
|
SIRP alpha Protein, Human, Recombinant (hFc)
|
Human
|
HEK293 Cells
|
|
SIRP alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64 kDa and the accession number is P78324-1.
|
|
TMPY-01701
|
IL-12RB1 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
IL-12RB1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.5 kDa and the accession number is P42701-1.
|
|
TMPY-04782
|
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is O75019-1.
|
|
TMPY-01907
|
VSIG4 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
VSIG4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.5 kDa and the accession number is Q9Y279-1.
|
|
TMPY-01462
|
IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.6 kDa and the accession number is Q14626-1.
|
|
TMPY-00828
|
Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfatase/IDS consists of a signal peptide, a propeptide, and a mature chain that may be further processed into two chains. Among the identified 18 human sulfatases, Iduronate 2-Sulfatase/IDS is required for the lysosomal degradation of the glycosaminoglycans (GAG), heparan sulfate, and dermatan sulfate. Multiple mutations in this X-chromosome localized gene result in Iduronate 2-Sulfatase/IDS enzymatic deficiency and lead to the sex-linked Mucopolysaccharidosis Type II (MPS II ), also known as Hunter Syndrome characterized by the lysosomal accumulation of the GAG and their excretion in urine. MPS II has a wide spectrum of clinical manifestations ranging from mild to severe due to the level of Iduronate 2-Sulfatase/IDS enzyme. Retroviral-mediated Iduronate 2-Sulfatase/IDS gene transfer into lymphoid cells would be a promising gene therapeutic strategy.
|
|
TMPY-01834
|
CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His)
|
Mouse
|
HEK293 Cells
|
|
CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.6 kDa and the accession number is P08508-1.
|
|
TMPY-01410
|
IL-3R alpha/CD123 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
IL-3R alpha/CD123 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.5 kDa and the accession number is P26951-1.
|
|
TMPY-03273
|
IL-18 Protein, Mouse, Recombinant
|
Mouse
|
E. coli
|
|
IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1.
|
|
TMPY-01431
|
L1CAM Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
L1CAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 125 kDa and the accession number is P32004-1.
|
|
TMPY-01298
|
CADM1 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
CADM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.5 kDa and the accession number is Q9BY67-1.
|
|
TMPY-04810
|
CD47 Protein, Mouse, Recombinant (His)
|
Mouse
|
HEK293 Cells
|
|
CD47 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.3 kDa and the accession number is Q61735-1.
|
|
TMPY-05579
|
PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated
|
Human
|
HEK293 Cells
|
|
PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61 kDa and the accession number is Q15223-1.
|
|
TMPY-05030
|
PCDH7 Protein, Human, Recombinant (His)
|
Human
|
Baculovirus Insect Cells
|
|
PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cancer. The low PCDH7 expression is a potential prognostic biomarker for primary non-muscle invasive bladder cancer (NMIBC). PCDH7 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 94 kDa and the accession number is O60245-1.
|
|
TMPY-06076
|
LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc)
|
Human
|
HEK293 Cells
|
|
LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.7 kDa and the accession number is Q8N149-1.
|
|
TMPY-02154
|
FAP Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
FAP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87.2 kDa and the accession number is Q12884-1.
|
|
TMPY-01912
|
Cadherin 17/CDH17 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Cadherin 17/CDH17 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87 kDa and the accession number is Q12864-1.
|
|
TMPY-01608
|
Decorin Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
Decorin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.4 kDa and the accession number is P07585-1.
|
|
TMPY-01573
|
SIRP alpha Protein, Human, Recombinant (G75A, His)
|
Human
|
HEK293 Cells
|
|
SIRP alpha Protein, Human, Recombinant (G75A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is P78324-1.
|
|
TMPY-04779
|
BTN3A2 Protein, Human, Recombinant (His)
|
Human
|
HEK293 Cells
|
|
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted evolution of BTN3 characterized by a strong and recurrent homogenization of the region encoding the signal peptide and the immunoglobulin variable (IgV) domain in Hominoids, where the sequences of BTN3A1 or BTN3A3 are replaced by BTN3A2 sequence.
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