目录号 | 产品详情 | 靶点 | |
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T60197 | Others | ||
UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. Notably, UNC1062 demonstrates potent inhibition of MERTK kinase activity, with an IC50 of 1.1 nM and a Morrison Ki of 0.33 nM. It also displays specificity within the TAM family, exhibiting IC50 values of 60 nM for TYRO3 and 85 nM for AXL [1]. | |||
T1797 | Apoptosis VEGFR c-Met/HGFR TAM Receptor c-Kit | ||
Cabozantinib S-malate (XL184) 是一种多受体酪氨酸激酶抑制剂, 抑制VEGFR2,c-Met,Kit,Axl 和Flt3的IC50分别为0.035,1.3,4.6,7 和 11.3 nM。 | |||
T5414 | c-Met/HGFR | ||
Glumetinib (SCC244) 是一种高选择性、ATP 竞争性的、口服具有活力的 c-Met 抑制剂。它对 c-Met 的选择性超过 312 种激酶,包括 c-Met 家族成员 RON 和高度同源的激酶 Axl、Mer、TyrO3。它具有抗肿瘤作用。 | |||
T6120 | Apoptosis DHFR Antifolate TAM Receptor | ||
Pralatrexate (10-Propargyl-10-deazaaminopterin) 是一种抗叶酸剂,也是二氢叶酸还原酶抑制剂,Ki 值为 13.4 pM。它具有抗肿瘤活性,可研究复发/难治性 T 细胞淋巴瘤。它是叶酰聚谷氨酸合成酶的底物,具有改善的细胞摄取和保留能力。 | |||
T36646 | Others | ||
Trastuzumab deruxtecan (T-DXd) 是一种具有抗癌抗肿瘤活性的抗体-活性分子偶联物 (ADC)。Trastuzumab deruxtecan 对 HER2 阳性乳腺癌和胃癌有改善作用。 | |||
T12650 | TAM Receptor | ||
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis. | |||
T78834 | HIF/HIF Prolyl-Hydroxylase | ||
Axl-IN-16(Compound 4)为Axl抑制剂,能够抑制Axl表达及抑制HIF活性,并诱导金针菇子实体形成。Axl-IN-16可通过分离红血球菌与猴头菇的“子实体液(FL)”得到。 | |||
T76723 | |||
Tilvestamab (BGB149) 是一种人源化抗AXL 抗体,阻断AXL 介导的细胞信号传导。Tilvestamab 在体外能显著抑制Gas6刺激诱导的AXL 激活,并抑制 786-0-Luc RCC 细胞中下游AXL 的磷酸化。Tilvestamab 可用于癌症,尤其是AXL 过度表达肾细胞癌的研究。 | |||
T74864 | |||
TL4830031 (compound 8i) 是一种喹诺酮类抗生素衍生物,是一种有效的 Axl 抑制剂,其 IC50值为 26 nM。TL4830031 抑制 Axl 的磷酸化。TL4830031 抑制细胞侵袭和迁移。TL4830031 可用于癌症研究。 | |||
T77085 | |||
Mipasetamab 是一种靶向AXL 的 IgG1κ 抗体,AXL 是一种酪氨酸激酶受体,或者是 TAM 受体 (TAM Receptor)。 Mipasetamab 参与 ADCT-601 (Mipasetamab uzoptirine) 的合成,这是一种 AXL 靶向的抗体-活性分子偶联物 (ADC)。ADCT-601 具有抗肿瘤作用。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01601 | AXL Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1.
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TMPY-06552 | AXL Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
AXL Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.72 kDa and the accession number is Q8VI99.
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TMPY-01021 | AXL Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
AXL Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 74.5 kDa and the accession number is Q00993.
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TMPK-00472 | AXL Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 46.3 kDa and the accession number is A0A1D5Q330.
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TMPY-06478 | AXL Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
AXL Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 72.11 kDa and the accession number is AAH32229.1.
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TMPJ-00399 | AXL Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
AXL Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is Q00993.
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TMPK-00407 | AXL Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 48.7 kDa and the accession number is P30530-1.
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TMPJ-00449 | AXL Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
AXL Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-115 KDa and the accession number is AAA61243.
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TMPY-01364 | AXL Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
AXL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.8 kDa and the accession number is Q00993.
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TMPK-00408 | AXL Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 48.7 kDa and the accession number is P30530-1.
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TMPK-00410 | AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells | ||
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 72.6 kDa and the accession number is P30530-1.
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TMPJ-00365 | GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated | Human | HEK293 Cells | ||
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. It also can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry.
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TMPY-04830 | GAS6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor progression by regulating growth in many cancers. GAS6, expressed by osteoblasts in the bone marrow, plays a significant role in the regulation of PCa cell survival during chemotherapy, which will have important implications for targeting metastatic disease. The GAS6/TYRO3-AXL-MERTK (TAM) signaling pathway is essential for full and sustained platelet activation, as well as thrombus stabilization. Inhibition of this pathway decreases platelet aggregation, shape change, clot retraction, aggregate formation under flow conditions, and surface expression of activation markers. It had been show that GAS6 signaling regulates invasion, proliferation, chemotherapy-induced apoptosis of prostate cancer (PCa) cells, and GAS6 secreted from osteoblasts in the bone marrow environment plays a critical role in establishing prostate tumor cell dormancy.
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TMPJ-00366 | GAS6 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
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TMPY-04999 | GAS6 Protein, Human, Recombinant (His) | ||||
GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells.
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TMPK-00517 | GAS6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological processes in cells, including proliferation, survival and migration, by binding to its receptors Tyro3, Axl and Mer (TAM).
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TMPJ-01081 | Dtk Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. The binding affinities for Gas6 is in the order of Axl > Dtk > Mer. Gas6 binding induces tyrosine phosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Dtk is widely expressed during embryonic development. In adults, Dtk is predominantly expressed in neurons in restricted regions of the brain.
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TMPJ-01143 | MERTK/Mer Protein, Human, Recombinant (aa 1-323, His) | Human | HEK293 Cells | ||
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that the MERTK plays critical role in the engulfment and efficient clearance of apoptotic cells, platelet aggregation, and cytoskeleton reorganization. Not only these, it also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. In addition, MERTK could regulate rod outer segments fragments phagocytosis in the retinal pigment epithelium (RPE), deficiency in MERTK are the cause of retinitis pigmentosa.
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