AXL Protein, Human, Recombinant (hFc)

Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness. It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

规格	价格/CNY		数量
10 μg	￥ 180	5日内发货
50 μg	￥ 580	5日内发货
500 μg	￥ 5,800	5日内发货
1 mg	￥ 8,700	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 180

5日内发货

50 μg

￥ 580

5日内发货

500 μg

￥ 5,800

5日内发货

1 mg

￥ 8,700

5日内发货

生物活性

1. Loaded Biotinylated Human GAS6-Avi-His on SA Biosensor, can bind Human AXL-Fc with an affinity constant of 1.02 pM as determined in BLI assay. (Regularly tested) 2. Immobilized Biotinylated Human GAS6-Avi-His at 2μg/ml (100 μl/well)can bind Human AXL-Fc. The ED50 of Human AXL-Fc is 12.54 ng/ml. (Regularly tested)

产品描述

种属	Human
表达系统	Human Cells
标签	C-Fc
蛋白编号	AAA61243
别名	UFO, Tyrosine-protein kinase receptor UFO, AXL oncogene
氨基酸序列	Ala26-Pro440
蛋白构建	Recombinant Human Tyrosine-protein kinase receptor UFO is produced by our Mammalian expression system and the target gene encoding Ala26-Pro440 is expressed with a human IgG1 Fc tag at the C-terminus.
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	90-115 KDa, reducing conditions

内毒素	Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶方法	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
存储	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
运输方式	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
研究背景	Axl, also known as Ufo and Ark, is a widely expressed 140 kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness. It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

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AXL Protein, Human, Recombinant (hFc)

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