目录号 | 产品详情 | 靶点 | |
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T8342 | Others Kinesin Microtubule Associated | ||
BRD9876 是一种 MM1S 生长的选择性抑制剂,可将驱动蛋白 5 锁定在增强微管结合的状态,从而导致 MT 的捆绑和稳定。它特异性靶向微管结合的 Eg5,选择性抑制 CD34 细胞的骨髓瘤,有用于多发性骨髓瘤的研究潜力。 | |||
T9207 | Kinesin Autophagy | ||
GW406108X (GW108X) 是一种 Kif15 抑制剂,在 ATPase 测定中的 IC50 为 0.82 uM。 它也是一种 ULK1 激酶抑制剂,pIC50 值为 6.37(427 nM),可阻断自噬通量。 | |||
T9207L | Kinesin Autophagy | ||
GW406108X(Z/E) 是不同配置的 GW406108X 的混合物,它是 Kinesin-12 和 ULK1 的抑制剂。 | |||
T39994 | Microtubule Associated | ||
Sovilnesib 是一种有效kinesin-like protein KIF18A 抑制剂。它可用于癌症的研究。 | |||
T77586 | Kinesin | ||
Eg5-IN-1 是一种有效的驱动蛋白家族运动蛋白 (Eg5) 抑制剂,对 Eg5 的 IC50 值为 1.97 µM。Eg5-IN-1 可用于研究癌症。 | |||
T23543 | GHSR | ||
YIL 781是一种选择性ghrelin 受体拮抗剂(GHS-R1a) (Ki = 17 nM)),对运动素受体显示出较弱的亲和力(K = 6 μ M)。YIL 781通过阻断胃饥饿素分泌对体内和体外胰岛素分泌改善体内葡萄糖稳态。 | |||
T9682 | Apoptosis Kinesin | ||
AZD-4877 是一种高效的纺锤体驱动蛋白 (Eg5) 抑制剂,对其 IC50 值为 2 nM。 AZD-4877 是 Ispinesib 的另一种构型, 能够抑制细胞有丝分裂,诱导形成单极纺锤体表型,介导细胞凋亡(Apoptosis)。 AZD-4877 具有抗肿瘤活性,对循环外周血单核细胞 (PBMC)有抑制作用。 | |||
TQ0318 | KSP | ||
Filanesib (ARRY 520) 是一种选择性的驱动蛋白纺锤体蛋白(KSP)的抑制剂(IC50 = 6 nM),具有强大的抗增殖活性。 | |||
TQ0318L | KSP | ||
ARRY 520 hydrochloride 是一种驱动蛋白纺锤体蛋白 (KSP) 抑制剂。它通过凋亡诱导细胞死亡,并具有有效的抗增殖活性。 | |||
T60026 | Microtubule Associated | ||
KIF18A-IN-2 是有丝分裂驱动蛋白 Kif18A 的抑制剂,IC50 为 28 nM,可用于染色体不稳定性相关漏洞的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00522 | KLC2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells | ||
KLC2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells with His and GST tag. The predicted molecular weight is 96.8 kDa. Accession number: Q9H0B6-1
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TMPY-00589 | KIAA1279 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells | ||
KIFBP (Kinesin Family Binding Protein, also known as KIAA1279 and KIF1BP) is a Protein Coding gene. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratricopeptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating the transport of the mitochondria. Homozygous nonsense mutations in KIAA1279 at 1q22.1, encoding a protein with two tetratricopeptide repeats, underlie this syndromic form of Hirschsprung disease and generalized polymicrogyria, establishing the importance of KIAA1279 in both enteric and central nervous system development. KIAA1279 is widely expressed in the brain, testis, and other tissues. Diseases associated with KIFBP include Goldberg-Shprintzen Syndrome and Shprintzen-Goldberg Craniosynostosis Syndrome.
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TMPY-03993 | KIAA1279 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells | ||
KIFBP (Kinesin Family Binding Protein, also known as KIAA1279 and KIF1BP) is a Protein Coding gene. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratricopeptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating the transport of the mitochondria. Homozygous nonsense mutations in KIAA1279 at 1q22.1, encoding a protein with two tetratricopeptide repeats, underlie this syndromic form of Hirschsprung disease and generalized polymicrogyria, establishing the importance of KIAA1279 in both enteric and central nervous system development. KIAA1279 is widely expressed in the brain, testis, and other tissues. Diseases associated with KIFBP include Goldberg-Shprintzen Syndrome and Shprintzen-Goldberg Craniosynostosis Syndrome.
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TMPJ-00972 | CDKN1B Protein, Human, Recombinant (His) | Human | E. coli | ||
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.
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TMPH-02846 | BICD2 Protein, Mouse, Recombinant (GST) | Mouse | E. coli | ||
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex. Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis.
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