细胞骨架化合物库 | 陶术生物

细胞骨架化合物库现货

Cytoskeletal Signaling Pathway Compound Library

产品编号： L1310

细胞骨架作为真核细胞中的动态蛋白纤维网结构，由微丝(microfilaments, MF)、微管(microtubules, MT)和中间纤维 (intermediate filaments, IF) 构成。微丝确定细胞表面特征，使细胞能够运动和收缩。微管确定膜性细胞器（membrane-enclosed organelle）的位置和作为膜泡运输的导轨。中间纤维使细胞具有张力和抗剪切力。

细胞骨架是细胞生命活动不可缺少的细胞结构，其形成的复杂网络体系对细胞形态的改变和维持、细胞的分裂与分化、细胞内的物质运输、细胞信息传递和基因表达等均具有重大的意义。细胞骨架结构发生异常往往与一些疾病有关。如阿尔茨海默症患者，在脑神经元中发现有大量扭曲变形的微管和大量受损的中间纤维；在恶性转化的细胞中，常表现为微管减少和解聚，细胞骨架异常可增强癌细胞的运动能力。

TargetMol 细胞骨架化合物库收集了773 种细胞骨架相关的化合物，作用靶点包括Microtubule/Tubulin、Kinesin、PKC、MAPK 等，可用于细胞骨架信号通路与相关疾病的药理研究和药物开发。

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产品规格

技术资料

陶术生物化合物库目录(28.1MB)

库化合物信息

Excel

SDF

产品特点

773种细胞骨架相关的化合物，可以用于高通量和高内涵筛选；
作用于细胞骨架相关的靶点，如Microtubule/Tubulin、Kinesin、PKC、MAPK等；
部分化合物已经得到FDA批准上市；
结构多样，药效显著，可渗透细胞；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

化合物库定制

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化合物库组成

Apoptosis (145)

Microtubule Associated (114)

Autophagy (102)

p38 MAPK (96)

Akt (93)

Wnt/beta-catenin (92)

PKC (77)

Bcr-Abl (63)

HSP (57)

MAPK (50)

ROCK (40)

Integrin (36)

Src (36)

NF-κB (30)

FAK (29)

ERK (27)

PI3K (23)

PKA (22)

Parasite (21)

Antibacterial (20)

Endogenous Metabolite (19)

Kinesin (19)

VEGFR (19)

CDK (18)

c-Kit (18)

PAK (18)

mTOR (16)

PDGFR (16)

JNK (15)

Myosin (15)

Antibiotic (13)

PARP (13)

Caspase (12)

Reactive Oxygen Species (12)

Rho (12)

COX (11)

S6 Kinase (11)

TNF (11)

BCL (10)

IGF-1R (10)

Aurora Kinase (9)

FGFR (9)

FLT (9)

STAT (9)

Antifungal (8)

Casein Kinase (8)

GSK-3 (8)

AMPK (7)

Dynamin (7)

EGFR (7)

Raf (7)

ALK (6)

ATPase (6)

Gap Junction Protein (6)

HIV Protease (6)

Influenza Virus (6)

JAK (6)

MEK (6)

Ras (6)

ASK (5)

CaMK (5)

c-Met/HGFR (5)

IL Receptor (5)

MMP (5)

NO Synthase (5)

PPAR (5)

PYK2 (5)

Serine/threonin kinase (5)

Topoisomerase (5)

Tyrosine Kinases (5)

Calcium Channel (4)

DNA/RNA Synthesis (4)

Ferroptosis (4)

GPR (4)

HER (4)

Lipoxygenase (4)

p53 (4)

PDK (4)

S1P Receptor (4)

SGK (4)

Syk (4)

TLR (4)

ACK (3)

Antifection (3)

c-Fms (3)

c-RET (3)

Gamma-secretase (3)

HIF (3)

HSV (3)

LDL (3)

Mitochondrial Metabolism (3)

Mitophagy (3)

P-gp (3)

Porcupine (3)

SARS-CoV (3)

Serine Protease (3)

Trk receptor (3)

Virus Protease (3)

AChR (2)

Adrenergic Receptor (2)

Antioxidant (2)

Antiviral (2)

Beta Amyloid (2)

BTK (2)

Carbonic Anhydrase (2)

Chk (2)

DNA Alkylation (2)

Drug Metabolite (2)

Ephrin Receptor (2)

Epigenetic Reader Domain (2)

GRK (2)

Guanylate cyclase (2)

Hck (2)

HCV Protease (2)

HDAC (2)

KSP (2)

LPL Receptor (2)

MLK (2)

MNK (2)

Monoamine Oxidase (2)

MyD88 (2)

Nrf2 (2)

PLK (2)

Potassium Channel (2)

Prostaglandin Receptor (2)

PTEN (2)

RAAS (2)

TGF-beta/Smad (2)

transporter (2)

5-HT Receptor (1)

Adenosine Receptor (1)

AhR (1)

Aminopeptidase (1)

Androgen Receptor (1)

Apelin receptor (1)

Arginase (1)

Aromatase (1)

Aryl Hydrocarbon Receptor (1)

Cannabinoid Receptor (1)

Complement System (1)

CRISPR/Cas9 (1)

DHFR (1)

DNA (1)

DUB (1)

DYRK (1)

Estrogen Receptor/ERR (1)

Estrogen/progestogen Receptor (1)

FXR (1)

Glucokinase (1)

Glucosidase (1)

Glutathione Peroxidase (1)

GST (1)

HBV (1)

Hedgehog/Smoothened (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histamine Receptor (1)

IRAK (1)

IκB/IKK (1)

Ligands for Target Protein for PROTAC (1)

LRRK2 (1)

Mdm2 (1)

MELK (1)

Methionine Adenosyltransferase (MAT) (1)

MRP (1)

NADPH (1)

NAMPT (1)

Nucleoside Antimetabolite/Analog (1)

PDE (1)

PERK (1)

Phosphatase (1)

PROTACs (1)

Tie-2 (1)

TRP/TRPV Channel (1)

YAP (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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