目录号 | 产品详情 | 靶点 | |
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T11859L | Kinesin | ||
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity. | |||
T15661 | Others | ||
Kif15-IN-1, a mitotic Kinesin family member 15 (Kif15) inhibitor, is utilized in the study of cellular proliferative diseases. | |||
T10428 | Microtubule Associated | ||
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor (Ki: 43 nM; IC50: 300 nM for KIFC1). | |||
T40232 | |||
KIF18A-IN-1 is a potent inhibitor of the mitotic kinesin KIF18A. This compound demonstrates significant anti-tumor properties. | |||
T24490 | |||
MMV666693 is a selective allosteric Plasmodium Kinesin-5 inhibitor. | |||
T63726 | |||
AM-5308 是驱动蛋白 KIF18A 的有效抑制剂。 | |||
T30573 | |||
BQS-481 inhibits Kinesin-like protein KIF11. | |||
T30308 | |||
BDPSB is a highly efficient photocontroller of mitotic kinesin Eg5 ATPase activity. | |||
T10373 | Others | ||
(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM). | |||
T78125 | Kinesin | ||
PVZB1194是一种联苯型激酶Eg5(亦称KIF11)抑制剂,与细胞周期相关,可以通过抑制Eg5的ATP酶活性导致细胞周期阻滞和细胞凋亡,从而显现抗癌潜力。该化合物与α4/α6变抗袋结合,展现ATP竞争性活性。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00522 | KLC2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells | ||
KLC2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells with His and GST tag. The predicted molecular weight is 96.8 kDa. Accession number: Q9H0B6-1
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TMPY-00589 | KIAA1279 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells | ||
KIFBP (Kinesin Family Binding Protein, also known as KIAA1279 and KIF1BP) is a Protein Coding gene. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratricopeptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating the transport of the mitochondria. Homozygous nonsense mutations in KIAA1279 at 1q22.1, encoding a protein with two tetratricopeptide repeats, underlie this syndromic form of Hirschsprung disease and generalized polymicrogyria, establishing the importance of KIAA1279 in both enteric and central nervous system development. KIAA1279 is widely expressed in the brain, testis, and other tissues. Diseases associated with KIFBP include Goldberg-Shprintzen Syndrome and Shprintzen-Goldberg Craniosynostosis Syndrome.
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TMPY-03993 | KIAA1279 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells | ||
KIFBP (Kinesin Family Binding Protein, also known as KIAA1279 and KIF1BP) is a Protein Coding gene. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratricopeptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating the transport of the mitochondria. Homozygous nonsense mutations in KIAA1279 at 1q22.1, encoding a protein with two tetratricopeptide repeats, underlie this syndromic form of Hirschsprung disease and generalized polymicrogyria, establishing the importance of KIAA1279 in both enteric and central nervous system development. KIAA1279 is widely expressed in the brain, testis, and other tissues. Diseases associated with KIFBP include Goldberg-Shprintzen Syndrome and Shprintzen-Goldberg Craniosynostosis Syndrome.
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TMPJ-00972 | CDKN1B Protein, Human, Recombinant (His) | Human | E. coli | ||
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.
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TMPH-02846 | BICD2 Protein, Mouse, Recombinant (GST) | Mouse | E. coli | ||
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex. Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis.
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