目录号 | 产品详情 | 靶点 | |
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T3118 | Kinesin | ||
Dimethylenastron 是一种驱动蛋白Eg5抑制剂,IC50值为 200 nM。它可阻止具有单极纺锤体的细胞,所有染色体都以单极纺锤体方式附着在该纺锤体上。 | |||
T4048 | Apoptosis Kinesin | ||
Monastrol ((±)-Monastrol) 是一种具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂,IC50值为 14 μM。 | |||
T6209 | Kinesin Microtubule Associated | ||
CW-069 是一种微管运动蛋白 HSET 的变构选择性抑制剂,IC50值为 75 μM,对 KSP 具有显着的特异性。 | |||
T36816 | Kinesin | ||
S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM,抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。 | |||
T2039 | Apoptosis Kinesin | ||
GSK923295 是一种特异性的变构着丝粒相关蛋白-E 驱动蛋白 ATPase 活性抑制剂,作用于人类和犬类此酶,Ki 分别为 3.2±0.2 nM 和 1.6±0.1 nM。 | |||
T12359 | Kinesin | ||
Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) 是可渗透细胞的 kinesin MKLP-2的抑制剂,抑制 MKLP-2 的 ATPase 活性,IC50值为 1.35 μM,Ki 值为 3.36 μM。它对 DYRK1A 有中等的抑制作用,IC50值为 5.5 μM。 | |||
T6393 | Kinesin | ||
ARQ 621 是一种变构和选择性 Eg5 有丝分裂运动蛋白抑制剂,具有抗肿瘤活性。 | |||
T3120 | Apoptosis Kinesin | ||
K858 Racemic (K858) 是一种选择性有丝分裂驱动蛋白 Eg5 抑制剂,以 ATP 非竞争性方式起作用,IC50值为 1.3 μM。 | |||
T2255 | Kinesin KSP | ||
SB-743921 hydrochloride (SB743921 HCl) 是一种有效的驱动蛋白纺锤体蛋白 KSP 抑制剂,Ki 值为 0.1 nM。 | |||
T2103 | Apoptosis Kinesin KSP | ||
Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂,具有抗肿瘤特性。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00522 | KLC2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells | ||
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TMPY-00589 | KIAA1279 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells | ||
KIFBP (Kinesin Family Binding Protein, also known as KIAA1279 and KIF1BP) is a Protein Coding gene. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratricopeptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating the transport of the mitochondria. Homozygous nonsense mutations in KIAA1279 at 1q22.1, encoding a protein with two tetratricopeptide repeats, underlie this syndromic form of Hirschsprung disease and generalized polymicrogyria, establishing the importance of KIAA1279 in both enteric and central nervous system development. KIAA1279 is widely expressed in the brain, testis, and other tissues. Diseases associated with KIFBP include Goldberg-Shprintzen Syndrome and Shprintzen-Goldberg Craniosynostosis Syndrome.
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TMPY-03993 | KIAA1279 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells | ||
KIFBP (Kinesin Family Binding Protein, also known as KIAA1279 and KIF1BP) is a Protein Coding gene. This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratricopeptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating the transport of the mitochondria. Homozygous nonsense mutations in KIAA1279 at 1q22.1, encoding a protein with two tetratricopeptide repeats, underlie this syndromic form of Hirschsprung disease and generalized polymicrogyria, establishing the importance of KIAA1279 in both enteric and central nervous system development. KIAA1279 is widely expressed in the brain, testis, and other tissues. Diseases associated with KIFBP include Goldberg-Shprintzen Syndrome and Shprintzen-Goldberg Craniosynostosis Syndrome.
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TMPJ-00972 | CDKN1B Protein, Human, Recombinant (His) | Human | E. coli | ||
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an activator of Cyclin Type D-CDK4 complexes depending on its phosphorylation state and stoichometry.
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TMPH-02846 | BICD2 Protein, Mouse, Recombinant (GST) | Mouse | E. coli | ||
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex. Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis.
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