目录号 | 产品详情 | 靶点 | |
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T40430 | |||
Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine is a second-generation antihistamine that acts as a specific, orally active, and long-acting antagonist of the histamine H1-receptor. Cetirizine exhibits antiallergic properties and inhibits eosinophil chemotaxis in response to allergies. | |||
T25618 | |||
Laninamivir trifluoroacetate 是一种抗病毒化合物,用于治疗和预防甲型流感病毒和乙型流感病毒。它是一种通过鼻吸入给药的长效神经氨酸酶抑制物。 | |||
T13032 | Others | ||
Sulfamonomethoxine D4 is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is an agent of long acting sulfonamide antibacterial, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate. | |||
TP1171 | |||
Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum. | |||
T37897 | |||
AM6538 is a long-acting, high affinity, and pseudo-irreversible cannabinoid antagonist, structurally analogous to rimonabant. It serves as a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. Additionally, AM6538 holds potential for future investigations that necessitate temporary reductions in cannabinoid receptor availability[1]. | |||
T78233 | Antibiotic | ||
Sulfamonomethoxine sodium用作血液动力学研究中的竞争性抑制剂,通过抑制二氢叶酸合成,进而阻断叶酸的生成。 | |||
T69491 | |||
(E/Z)-Ensifentrine is a potent and selective PDE3/4 inhibitor. (E/Z)-Ensifentrine acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and antiinflammatory effects. It is being developed by Verona Pharma as a potential treatment for asthma and hay fever, and is currently in clinical trials. | |||
T13106 | Adrenergic Receptor | ||
TD-5471 hydrochloride 是一种具有选择性和有效性的长效人 β2 肾上腺素能受体激动剂,可用于治疗治疗慢性阻塞性肺疾病(COPD)。 | |||
T13091L | |||
Taspoglutideacetate (275371-94-3 Free base) 是一种长效胰高血糖素样肽 1 (GLP-1) 受体激动剂,可用于有关 2 型糖尿病的研究。 | |||
T19390 | Others | ||
L-ascorbic acid 2-phosphate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation. L-ascorbic acid 2-phosphate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01816 | Pentraxin 3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
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TMPJ-00981 | PTX3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.
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