目录号 | 产品详情 | 靶点 | |
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T82924 | |||
Balugrastim (CG 10639)为新型长效G-CSF,由重组人血清白蛋白与G-CSF遗传融合制成,适用于乳腺癌研究。 | |||
T14210 | LTR | ||
Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long acting LTB4 receptor antagonist, negligibly binds to LTB4 receptor, with Kis of 221 nM and 230 nM | |||
T40899 | |||
2-Chloroacetamide is a versatile chemical compound with several applications. Acting as a preservative and herbicide, it effectively controls vegetation in upland areas as well as paddy fields. Additionally, it serves as a biocide in diverse sectors including agriculture, glues, paints, and coatings. Notably, 2-Chloroacetamide demonstrates inhibitory properties toward very-long-chain fatty acid elongase, further highlighting its multifaceted nature. | |||
T80876 | |||
Vasomera是一種穩定的長效血管活性腸肽(VIP)激動劑,主要作用於G蛋白偶聯的VPAC2受體,適用於與肌肉營養不良症相關的心肌病研究。 | |||
T77171 | |||
Efineptakin alfa (NT-17) 是一种长效重组人 IL-7。 Efineptakin alfa 支持人和小鼠体内 CD4+和 CD8+细胞的增殖和存活。 Efineptakin alfa 可用于胶质母细胞瘤的研究。 | |||
T73981 | |||
Deschloro Cetirizine Dihydrochloride 为 Cetirizine 杂质(impurity)。Cetirizine 属于第二代抗组胺药,作为羟嗪羧化代谢物,它表现为特异性、口服活性的长效组胺 H1 受体(histamine H1-receptor)拮抗剂。 | |||
T0366L | |||
Cefadroxil is a first generation aminocephalosporin with good patient compliance, a long-acting therapeutic effect, high solubility and relatively broad spectrum of anti-bacterial activity. Cefadroxil is also a substrate of the intestinal peptide transporter PepT1, which is primarily responsible for the drug's uptake across the apical membrane of small intestine. | |||
T73933 | |||
Cetirizine methyl ester 是Cetirizine 的杂质。Cetirizine 是羟嗪的羧化代谢物,是第二代抗组胺剂。Cetirizine 是一种特异的、具有口服活性的 H1 受体 (histamine H1-receptor) 的长效拮抗剂。 | |||
T81663 | |||
NN1177为一种长效GLP-1/胰高血糖素受体共激动剂,其能够在饮食诱导肥胖(DIO)小鼠中引发剂量依赖性的体重下降。NN1177适用于减肥与代谢控制研究领域。 | |||
TMIH-0583 | |||
Trelagliptin-13C-d3 是 Trelagliptin 的 13C 和氘代化合物。Trelagliptin 的 CAS 号为 865759-25-7。Trelagliptin 是一种有效的,具有口服活性的DPP-4抑制剂,IC50=4 nM。它可以改善体内血糖控制,能够用于2 型糖尿病 (T2DM) 的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01816 | Pentraxin 3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
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TMPJ-00981 | PTX3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.
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