目录号 | 产品详情 | 靶点 | |
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T26536 | |||
AC-178335 is a pure somatostatin (SRIF) antagonist with an affinity constant (Ki) of 172 +/- 12 nM. AC-178335 blocks SRIF inhibition of adenylate cyclase in vitro (IC50 = 5.1 +/- 1.4 microM). It induces GH release when given alone (50 micrograms intraveno | |||
T76001 | |||
Apraglutide TFA (FE 203799 TFA) 是一种合成的、含33个氨基酸的肽类药物,为长效GLP-2类似物。它能在全回肠切除后导致的新生短肠综合征小猪中增强适应性和线性肠生长。 | |||
T76262L | |||
Cagrilintide acetate 是一种非选择性的 AMYR/CTR 激动剂和长效酰化淀粉酶类似物。Cagrilintide acetate 以剂量依赖的方式导致食物摄入减少和体重明显下降。Cagrilintide acetate 可用于肥胖症的研究。 | |||
T64252 | |||
Efpeglenatide 是一种胰高血糖素样肽 (GLP-1) 受体的长效激动剂。Efpeglenatide 能够改善糖尿病和肥胖小鼠模型的胰岛素敏感性,并减缓其体重减轻的作用。Efpeglenatide 已经被用于 II 型糖尿病的研究。 | |||
T64151 | |||
Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) 是一种长效的钙离子通道拮抗剂。Mibefradil dihydrochloride hydrate 通过对低电压激活 (T) 钙通道的亲和力高于对高电压激活 (L) 钙通道的亲和力来发挥作用。Mibefradil dihydrochloride hydrate 能够降压药。 | |||
T73962 | |||
Cetirizine Impurity C dihydrochloride 为Cetirizine杂质之一,属于羟嗪的羧化代谢物,是第二代抗组胺剂中的一个。其为具有特异性且口服有效的H1受体(histamine H1-receptor)长效拮抗剂。 | |||
T78328 | |||
Efbemalenograstim alfa(F 627)为重组长效二聚体G-CSF,融合了两个人源G-CSF与人免疫球蛋白G2(hIgG2)-Fc片段,并能有效促进白细胞生成。 | |||
T81526 | |||
Pegsebrenatide (NLY01) 是一种具有扩展半衰期和优良血脑屏障穿透能力的长效GLP-1R激动剂。该化合物能够抑制A1型星形胶质细胞的活化,降低多巴胺能神经元凋亡,并在帕金森病(PD)小鼠模型中改善运动功能障碍。 | |||
T76262 | |||
Cagrilintide为一种处于研发阶段的新型长效酰化胰岛素类似物,兼具非选择性胰岛素受体(AMYR)与降钙素G蛋白偶联受体(CTR)的激动剂功能。该化合物能显著降低体重并减少食物摄入,展现出针对肥胖疾病的研究潜力。 | |||
T75248 | |||
Pasireotide (SOM230) diaspartate 是一种长效的环己肽生长激素抑制素类似物,可以提高生长抑素受体的激动剂活性,对sst1/2/3/4/5的pKi 分别为 8.2/9.0/9.1/<7.0/9.9。Pasireotide diaspartate 具有抗分泌、抗增殖和促凋亡活性。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01816 | Pentraxin 3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
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TMPJ-00981 | PTX3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.
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