目录号 | 产品详情 | 靶点 | |
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T2645 | Adrenergic Receptor | ||
Vilanterol 是一种长效的β2-AR 激动剂,效力持续24小时,能够作用于β2-AR (pEC50=10.37),β1-AR (pEC50=6.98) 和 β3-AR (pEC50=7.36)。 | |||
T34762 | |||
T-0201 (TA 0201) is a highly potent, long-acting, orally active, and selective ETA receptor antagonist. T-0201 also inhibited ET-1-induced pulmonary artery contraction in isolated rabbits. | |||
T39820 | |||
Dapiglutide (ZP7570) is a long-acting dual agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucagon-like peptide-2 receptor (GLP-2R) that holds potential for short bowel syndrome (SBS) research. | |||
T16433 | 5-HT Receptor | ||
Pancopride(LAS 30451) 是一种可口服的新型有长效的选择性 5-HT3 受体拮抗剂,可阻断氮芥和达卡巴嗪诱导的呕吐。 | |||
T80769 | |||
Wy 41747 为长效生长抑素类似物,适用于糖尿病研究领域。 | |||
T69102 | |||
Pheniprazine 是一种有效的长效monoamine oxidase 抑制剂。Pheniprazine 具有研究抑郁症的潜力。 | |||
T19233 | Others | ||
Cetirizine D4 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist. | |||
T69475 | |||
Dinalbuphine sebacate is a long-lasting prodrug of nalbuphine, acting as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor and as a high-efficacy partial agonist of the κ-opioid receptor. | |||
T74163 | |||
TGFβR-IN-1 是一种长效肿瘤激活的TGFβR 抑制剂的前体。 | |||
T10770 | Histamine Receptor | ||
Cetirizine D8 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01816 | Pentraxin 3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
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TMPJ-00981 | PTX3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.
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