目录号 | 产品详情 | 靶点 | |
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T22339 | Others PI3K | ||
GNE-490 是一种有效的 pan-PI3K 抑制剂,对 PI3Kα、PI3Kβ、PI3Kδ 和 PI3Kγ 的 IC50 分别为 3.5 nM、25 nM、5.2 nM、15 nM。 GNE-490 对 mTOR 具有 >200 倍的特异性(IC50 = 750 nM)。 | |||
T5S0506 | Apoptosis Others p38 MAPK Akt mTOR | ||
Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物,具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。 | |||
T6251 | Akt PI3K mTOR Autophagy | ||
PF-04691502 是一种有效的选择性 PI3K 和 mTOR 激酶抑制剂,具有抗肿瘤活性。它与人 PI3Kα、β、δ、γ和 mTOR 结合的 Ki 分别为1.8、2.1、1.6、1.9和16 nM。 | |||
T3351 | Apoptosis c-Fms DNA-PK FLT PI3K mTOR | ||
Onatasertib (CC223) 是一种口服有效的mTOR 激酶抑制剂,抑制mTOR 激酶,IC50为 16 nM。它抑制mTORC1和mTORC2。 | |||
T2415 | Apoptosis VEGFR Bcr-Abl PDGFR Src mTOR Hck | ||
PP121是一种多靶点激酶抑制剂,抑制 PDGFR、Hck、mTOR、VEGFR2、Src、Abl、DNK-PK 的 IC50值分别为2、8、10、12、14、18、60 nM。 | |||
T3895 | Apoptosis Akt JNK PDK mTOR Autophagy | ||
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。 | |||
T79212 | mTOR | ||
mTORinhibitor-12(Compound 11)为选择性脑渗透性mTOR抑制剂,无遗传毒性风险,适用于中枢神经系统疾病研究。 | |||
T79211 | mTOR | ||
mTORinhibitor-11(Compound 9)是具有穿透血脑屏障能力的mTOR抑制剂,其IC50针对pS6为21 nM。该化合物还可抑制pCHK1及PDE4D,其IC50值分别为17.2 μM和17.0 μM,适用于中枢神经系统疾病的研究。 | |||
T6319 | DNA-PK PI3K mTOR Autophagy | ||
OSI-027 (ASP4786) 是一种选择性、可口服和 ATP 竞争性的mTOR 激酶活性抑制剂,IC50为 4 nM。它抑制mTORC1和mTORC2,IC50分别为 22 nM 和 65 nM。 | |||
T6346 | Apoptosis mTOR | ||
WYE-132 (WYE-125132) 是一种高度有效的 ATP 竞争性和特异性 mTOR 激酶抑制剂,IC50为 0.19±0.07 nM。它抑制 mTORC1和 mTORC2。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02089 | mTOR Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
mTOR Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.2 kDa and the accession number is P42345.
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TMPY-02252 | LAMTOR2 Protein, Human, Recombinant (His) | Human | E. coli | ||
Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP, and ROBLD3, is a protein which belongs to the GAMAD family. LAMTOR2 / ROBLD3 is a regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, LAMTOR2 / ROBLD3 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in the activation of the TOR signaling cascade by amino acids. LAMTOR2 / ROBLD3 is an adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Defects in LAMTOR2 are the cause of immunodeficiency due to defects in MAPBP-interacting protein (ID-MAPBPIP). This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature, and B-cell and cytotoxic T-cell deficiency.
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TMPJ-01378 | Mp1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.
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TMPY-04540 | S6K1/RPS6KB1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is dissociated from the EIF3 complex and activated upon mitogenic stimulation, phosphorylation by the mammalian target of mTOR complex 1 (mTORC1). Its active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. PS6K also functions in cell proliferation, cell growth and cell cycle progression.
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TMPK-00524 | CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 41.03 kDa and the accession number is A0A2K5VQG9.
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TMPK-00283 | CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
CA9 is a member of the carbonic anhydrases' family, that is often expressed in cancer cells under hypoxic condition. CA9 expression potentially contributes to the regulation of cancer cell differentiation and mediates tumour-associated genes and signalling pathways, including apoptosis, hypoxia, G2M checkpoint, PI3K/AKR/mTOR signalling and TGF-beta signalling pathways. CA9/Carbonic Anhydrase IX Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 43.7 kDa and the accession number is Q16790.
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TMPY-06821 | THRB Protein, Human, Recombinant (His) | Human | E. coli | ||
Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present on promoters of TH-responsive genes. Located on chromosome 3p24, THRB gene mutation has been linked to autosomal dominant resistance to TH (RTH), which is characterized by goiter and elevated levels of T3, T4, and TSH. THRB is a known pharmacological target for the treatment of non-alcoholic steatohepatitis (NASH). THRB may be a target for future cancer therapies since its knockdown enhanced the viability of endometrial cancer cells and activated the mTOR-4EBP1/eIF4G pathway.
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TMPH-02855 | PML Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum. Regulates RB1 phosphorylation and activity. Acts as both a negative regulator of PPARGC1A acetylation and a potent activator of PPAR signaling and fatty acid oxidation. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization. Regulates PER2 nuclear localization and circadian function. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. Required for normal development of the brain cortex during embryogenesis. Plays a role in granulopoiesis or monopoiesis of myeloid progenitor cells. May play a role regulating stem and progenitor cell fate in tissues as diverse as blood, brain and breast. Shows antiviral activity towards lymphocytic choriomeningitis virus (LCMV) and the vesicular stomatitis virus (VSV).
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