目录号 | 产品详情 | 靶点 | |
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T5S1805 | Others Virus Protease PARP Caspase Nrf2 | ||
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。 | |||
T64289 | |||
Rucaparib (AG014699) camsylate 是一种口服具有活力的 PARP 蛋白 (PARP-1、PARP-2 及 PARP-3) 抑制剂,对 PARP-1 的 Ki=1.4 nM。Rucaparib camsylate 是一种六磷酸己糖脱氢酶 (H6PD) 抑制剂。Rucaparib camsylate 具有潜力进行去势抵抗性前列腺癌 (CRPC) 的研究研究。 | |||
T71026 | |||
MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells. | |||
T24638 | |||
Picrasidine M is a PARP-1 inhibitor. | |||
T63065 | |||
Rucaparib (AG014699) tartrate 是一种口服具有活力的 PARP 蛋白 (PARP-1, PARP-2 和 PARP-3) 抑制剂,作用于 PARP-1 (Ki: 1.4 nM)。Rucaparib tartrate 是一种六磷酸己糖脱氢酶 (H6PD) 抑制剂。Rucaparib tartrate 具有潜力用于去势抵抗性前列腺癌 (CRPC) 的研究。 | |||
T75344 | |||
NCT-TFP 是 PARP 探针,用于鉴定聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。 | |||
T22756 | Others | ||
EB 47 is an effective inhibitor of PARP-1 (IC50: 45 nM). | |||
T61335 | |||
Rucaparib hydrochloride, also known as AG014699, is a powerful and orally active compound that inhibits PARP proteins including PARP-1, PARP-2, and PARP-3 with a Ki value of 1.4 nM for PARP1. Additionally, Rucaparib hydrochloride acts as a modest inhibitor of hexose-6-phosphate dehydrogenase (H6PD). This compound shows potential in research for castration-resistant prostate cancer (CRPC) [1] [2] [3] [4]. | |||
T70732 | |||
APX2014 is a novel potent and specific Ref-1 inhibitor, blocking in vitro cell proliferation and activating apoptosis via PARP cleavage. | |||
T61657 | |||
Rucaparib (AG014699) acetate is a highly effective oral inhibitor of PARP proteins, specifically targeting PARP-1, PARP-2, and PARP-3, with a Ki value of 1.4 nM for PARP1. Additionally, it exhibits inhibitory action on hexose-6-phosphate dehydrogenase (H6PD) to a moderate extent. Rucaparib acetate shows promise in the field of research for castration-resistant prostate cancer (CRPC). [1] [2] [3] [4] |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01188 | PARP Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
PARP Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 114.5 kDa and the accession number is A0A024R3T8.
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TMPY-02465 | PARP Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells | ||
PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 115 kDa and the accession number is Q921K2.
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TMPY-02831 | Caspase-7 Protein, Human, Recombinant (His) | Human | E. coli | ||
Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are two major classes of caspases: initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED. Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. Caspase 7 exists in lung, skeletal muscle, liver, kidney, spleen, heart, and moderately in testis. Caspase 7 cannot be detected in the brain. Caspase 7 functions in the activation cascade of caspases responsible for apoptosis execution. It cleaves and activates sterol regulatory element binding proteins (SREBPs). It proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death.
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TMPY-04451 | AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&Q13131-1.
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TMPY-03878 | Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells | ||
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
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TMPY-02501 | CD3D & CD3E Heterodimer Protein, Human, Recombinant | Human | HEK293 Cells | ||
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
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TMPY-03745 | CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells | ||
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
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TMPY-04069 | Neurotrophin 3 Protein, Human, Recombinant | Human | E. coli | ||
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. NTF3 is capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-200c. NTF3 is broadly expressed in the ovary, spleen, and other tissues. Diseases associated with NTF3 include Hypochondriasis and Demyelinating Disease.
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TMPY-01349 | ICAM-1/CD54 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ICAM-1/CD54 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.7 kDa and the accession number is P13597-1.
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TMPY-01257 | uPAR/PLAUR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
uPAR/PLAUR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.4 kDa and the accession number is P35456-1.
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TMPY-01139 | PDGFRA Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number is P16234-1.
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TMPY-01459 | TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1.
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TMPY-00986 | IL-34 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
IL-34 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is Q8R1R4-1.
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TMPY-01298 | CADM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CADM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.5 kDa and the accession number is Q9BY67-1.
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TMPY-01968 | CD32A Protein, Human, Recombinant (167 His, His) | Human | HEK293 Cells | ||
CD32A Protein, Human, Recombinant (167 His, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22 kDa and the accession number is P12318-1.
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TMPY-04782 | LILRA1/LIR-6/CD85i Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50 kDa and the accession number is O75019-1.
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TMPY-04824 | CTLA-4 Protein, Human, Recombinant | Human | HEK293 Cells | ||
CTLA-4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P16410-1.
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TMPY-02105 | SCF Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells | ||
SCF Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.
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TMPY-00828 | Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfatase/IDS consists of a signal peptide, a propeptide, and a mature chain that may be further processed into two chains. Among the identified 18 human sulfatases, Iduronate 2-Sulfatase/IDS is required for the lysosomal degradation of the glycosaminoglycans (GAG), heparan sulfate, and dermatan sulfate. Multiple mutations in this X-chromosome localized gene result in Iduronate 2-Sulfatase/IDS enzymatic deficiency and lead to the sex-linked Mucopolysaccharidosis Type II (MPS II ), also known as Hunter Syndrome characterized by the lysosomal accumulation of the GAG and their excretion in urine. MPS II has a wide spectrum of clinical manifestations ranging from mild to severe due to the level of Iduronate 2-Sulfatase/IDS enzyme. Retroviral-mediated Iduronate 2-Sulfatase/IDS gene transfer into lymphoid cells would be a promising gene therapeutic strategy.
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TMPY-01333 | HDAC8 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1.
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TMPY-01280 | FOLR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
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TMPY-06051 | SIRP alpha Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
SIRP alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64 kDa and the accession number is P78324-1.
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TMPY-01912 | Cadherin 17/CDH17 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Cadherin 17/CDH17 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87 kDa and the accession number is Q12864-1.
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TMPY-00586 | CLEC-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
CLEC-2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9JL99-1.
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TMPY-04779 | BTN3A2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted evolution of BTN3 characterized by a strong and recurrent homogenization of the region encoding the signal peptide and the immunoglobulin variable (IgV) domain in Hominoids, where the sequences of BTN3A1 or BTN3A3 are replaced by BTN3A2 sequence.
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TMPY-03762 | E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.1 kDa and the accession number is P12830-1.
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TMPY-00915 | Serpin A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Serpin A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is P01009-1.
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TMPY-00908 | Renin Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Renin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is P00797-1.
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TMPY-03956 | Fas Ligand Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 19.3 kDa and the accession number is P48023-1.
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TMPY-05277 | IL-4R Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
IL-4R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.5 kDa and the accession number is P24394-1.
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TMPY-01462 | IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.6 kDa and the accession number is Q14626-1.
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TMPK-00176 | BAFF/TNFSF13B Trimer Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells | ||
B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene.BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. BAFF/TNFSF13B Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 52.4 kDa and the accession number is Q9Y275-1.
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TMPY-05579 | PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 Cells | ||
PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61 kDa and the accession number is Q15223-1.
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TMPY-03363 | C-Reactive Protein Protein, Human, Recombinant | Human | HEK293 Cells | ||
C-Reactive Protein Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23 kDa and the accession number is P02741-1.
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TMPY-00939 | Thrombopoietin Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Thrombopoietin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is P40226-1.
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TMPK-01151 | MXRA8 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 36.70 kDa and the accession number is Q9BRK3-1.
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TMPY-05566 | Siglec-2/CD22 Protein, Human, Recombinant (His, Solution) | Human | HEK293 Cells | ||
Siglec-2/CD22 Protein, Human, Recombinant (His, Solution) is expressed in HEK293 mammalian cells with His tag. The accession number is P20273-1.
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TMPY-01701 | IL-12RB1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-12RB1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.5 kDa and the accession number is P42701-1.
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TMPY-04810 | CD47 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
CD47 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.3 kDa and the accession number is Q61735-1.
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TMPY-04413 | IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) | Human | Baculovirus Insect Cells | ||
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 86 kDa and the accession number is O75460-1.
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TMPY-00664 | ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 81.6 kDa and the accession number is O15123-1.
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TMPY-02512 | Alpha-Synuclein Protein, Human, Recombinant | Human | E. coli | ||
Alpha-Synuclein Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.5 kDa and the accession number is P37840-1.
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TMPY-05435 | ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is Q15389-1.
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TMPY-01209 | IL-7R alpha/CD127 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
IL-7R alpha/CD127 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P16871-1.
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TMPY-01431 | L1CAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
L1CAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 125 kDa and the accession number is P32004-1.
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TMPY-00991 | LIFR Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
LIFR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 91 kDa and the accession number is P42702-1.
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TMPY-01853 | SIRP gamma Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SIRP gamma Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.5 kDa and the accession number is Q9P1W8-1.
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TMPY-06076 | LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
LILRA2/CD85h/ILT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.7 kDa and the accession number is Q8N149-1.
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TMPY-05030 | PCDH7 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
PCDH7, a member of protocadherins family, functions as tumor suppressor in several human cancers. The human PCDH7 gene is localized in chromosome 4p15, which is often inactivated in human cancers, including bladder cancer. The low PCDH7 expression is a potential prognostic biomarker for primary non-muscle invasive bladder cancer (NMIBC). PCDH7 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 94 kDa and the accession number is O60245-1.
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TMPY-02412 | ENO1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ENO1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 49.3 kDa and the accession number is P06733-1.
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